Methods and systems for detecting epileptic events using NNXX, optionally with nonlinear analysis parameters
First Claim
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1. A non-transitory computer readable storage device storing instructions that, when executed by a processor, cause the processor to perform operations comprising:
- receiving data related to a beat sequence of a patient'"'"'s heart;
dynamically recalculating an XX value used to determine at least one NNXX value, wherein the at least one NNXX value corresponds to a number of adjacent normal R-R intervals in a sample that differ by more than XX milliseconds;
determining the at least one NNXX value based on the beat sequence of the patient'"'"'s heart;
performing a first comparison of the at least one NNXX value to an NNXX threshold; and
providing an output indicative of an unstable brain state, a brain state indicative of an elevated probability of a seizure event, a brain state indicative of an impending seizure, an aura, a seizure, or a combination thereof, wherein the output is determined based on the first comparison.
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Abstract
Disclosed herein are methods, systems, and apparatus for detecting an epilepsy event in a patient using a medical device. The medical device is capable of determining an occurring epilepsy event, for example a seizure or an increased risk of a seizure. The determination is performed by determining at least one NNXX value from the beat sequence of the patient'"'"'s heart. The medical device may then take a responsive action, such as warning, logging the time of the seizure, computing and storing one or more seizure severity indices, and treating the epilepsy event.
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Citations
21 Claims
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1. A non-transitory computer readable storage device storing instructions that, when executed by a processor, cause the processor to perform operations comprising:
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receiving data related to a beat sequence of a patient'"'"'s heart; dynamically recalculating an XX value used to determine at least one NNXX value, wherein the at least one NNXX value corresponds to a number of adjacent normal R-R intervals in a sample that differ by more than XX milliseconds; determining the at least one NNXX value based on the beat sequence of the patient'"'"'s heart; performing a first comparison of the at least one NNXX value to an NNXX threshold; and providing an output indicative of an unstable brain state, a brain state indicative of an elevated probability of a seizure event, a brain state indicative of an impending seizure, an aura, a seizure, or a combination thereof, wherein the output is determined based on the first comparison. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A non-transitory computer readable storage device storing instructions that, when executed by a processor, cause the processor to perform operations comprising:
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receiving data related to a beat sequence of a patient'"'"'s heart; determining, based on the beat sequence, a first cardiac parameter and a second cardiac parameter; adjusting the first cardiac parameter based on the second cardiac parameter to generate an adjusted first cardiac parameter; performing a comparison of the adjusted first cardiac parameter to a first cardiac parameter threshold; providing an output indicative of an occurrence of a seizure event of the patient based on the comparison, wherein the first cardiac parameter is adjusted based on a nonlinear mathematical function, wherein the first cardiac parameter corresponds to an XX parameter for determining an NNXX value according to a number of adjacent normal R-R intervals in a sample that differ by more than XX milliseconds, wherein the XX parameter is dynamically adjusted based on an equation;
XX=(a+b*x),wherein x is a standard deviation (SD) value or a root mean squared successive distances (RMSSD) value, wherein the SD value and the RMSSD value are based on each interval between beats of the beat sequence of the patient'"'"'s heart, wherein a is a first constant, and wherein b is a second constant. - View Dependent Claims (12)
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13. A non-transitory computer readable storage device storing instructions that, when executed by a processor, cause the processor to perform operations comprising:
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receiving data related to a beat sequence of a patient'"'"'s heart; dynamically recalculating an XX value used to determine at least one NNXX value corresponding to a number of adjacent normal R-R intervals in a sample that differ by more than XX milliseconds, wherein the XX value is dynamically recalculated based on an equation;
XX=(a+b*x), wherein x is a standard deviation (SD) value or a root mean squared successive distances (RMSSD) value, wherein the SD value and the RMSSD value are based on each interval between beats of the beat sequence of the patient'"'"'s heart, wherein a is a first constant, and wherein b is a second constant;determining the at least one NNXX value based on the beat sequence of the patient'"'"'s heart and the XX value; performing a first comparison of the at least one NNXX value to an NNXX threshold; and providing an output indicative of an unstable brain state, a brain state indicative of an elevated probability of a seizure event, a brain state indicative of an impending seizure, an aura, a seizure, or a combination thereof, wherein the output is determined based on the first comparison. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
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Specification