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System for assessing the efficacy of stored red blood cells using microvascular networks

  • US 8,828,226 B2
  • Filed: 04/14/2009
  • Issued: 09/09/2014
  • Est. Priority Date: 03/01/2003
  • Status: Active Grant
First Claim
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1. A system comprising:

  • a network device comprising;

    an inlet;

    an outlet;

    at least one network unit in fluid communication with said inlet and said outlet comprising a plurality of microchannels,wherein said plurality of microchannels comprisesi) at least one parent microchannel branching into two daughter microchannels of unequal diameter or width, at least one of said two daughter microchannels branching at an angle from approximately 20°

    to approximately 80°

    , measured relative to the axis of said at least one parent channel, andii) at least one converged microchannel converging from two microchannels at an angle from approximately 20°

    to approximately 80°

    , measured relative to the axis of said at least one converged microchannel;

    andan analysis device comprising;

    one or more sensors configured to capture measurements related to a sample of blood cells flowing from said inlet to said outlet when said system is in use; and

    a processor comprising a memory device for determining the microvascular fitness of said sample of blood cells based on said measurements.

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