Production of isobutanol in yeast mitochondria
First Claim
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1. A recombinant yeast cell comprising a heterologous gene encoding a mitochondrial localized polypeptide having α
- -keto acid decarboxylase activity and wherein the mitochondria is substantially devoid of a functional polypeptide having threonine deaminase activity and a functional polypeptide having isopropylmalate synthase activity.
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Abstract
Yeast cells with modified expression of certain enzyme activities in the mitochondria are described for isobutanol production. Modifications described provide an isobutanol biosynthesis pathway in the yeast mitochondria.
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9 Claims
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1. A recombinant yeast cell comprising a heterologous gene encoding a mitochondrial localized polypeptide having α
- -keto acid decarboxylase activity and wherein the mitochondria is substantially devoid of a functional polypeptide having threonine deaminase activity and a functional polypeptide having isopropylmalate synthase activity.
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