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Insulin derivatives

  • US 8,828,923 B2
  • Filed: 09/16/2009
  • Issued: 09/09/2014
  • Est. Priority Date: 08/05/2003
  • Status: Active Grant
First Claim
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1. An insulin derivative which is a naturally occurring insulin or an analogue thereof which has a side chain attached to the α

  • -amino group of the N-terminal amino acid residue of the B chain or to the ε

    -amino group of a Lys residue present in the B chain of the parent insulin, the side chain being of the general formula;




    W—

    X—

    Y—

    ZwhereinW is two amino acid residues linked together via amide bonds, which chain—

    via an amide bond—

    is linked to the α

    -amino group of the N-terminal amino acid residue of the B chain or to the ε

    -amino group of a Lys residue present in the B chain of the parent insulin, the amino acid residues of W being selected from the group of amino acid residues having a neutral side chain and amino acid residues having a carboxylic acid group in the side chain so that W has at least one amino acid residue which has a carboxylic acid group in the side chain;

    X is —

    CO—

    ;

    Y is —

    (CH2)m

    where m is an integer in the range of 6 to 32; and

    Z is —

    COOH;

    and any Zn2+complexes thereof.

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