Insulin derivatives
First Claim
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1. An insulin derivative which is a naturally occurring insulin or an analogue thereof which has a side chain attached to the α
- -amino group of the N-terminal amino acid residue of the B chain or to the ε
-amino group of a Lys residue present in the B chain of the parent insulin, the side chain being of the general formula;
—
W—
X—
Y—
ZwhereinW is two amino acid residues linked together via amide bonds, which chain—
via an amide bond—
is linked to the α
-amino group of the N-terminal amino acid residue of the B chain or to the ε
-amino group of a Lys residue present in the B chain of the parent insulin, the amino acid residues of W being selected from the group of amino acid residues having a neutral side chain and amino acid residues having a carboxylic acid group in the side chain so that W has at least one amino acid residue which has a carboxylic acid group in the side chain;
X is —
CO—
;
Y is —
(CH2)m—
where m is an integer in the range of 6 to 32; and
Z is —
COOH;
and any Zn2+complexes thereof.
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Abstract
The present invention relates to insulin derivatives which are naturally occurring insulins or analogues thereof which have a side chain attached either to the α-amino group of the N-terminal amino acid residue of the B chain or to the ε-amino group of a Lys residue present in the B chain of the parent insulin, the side chain being of the general formula:
—W—X—Y—Z
wherein W, X, Y and Z are as defined in the disclosure.
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Citations
16 Claims
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1. An insulin derivative which is a naturally occurring insulin or an analogue thereof which has a side chain attached to the α
- -amino group of the N-terminal amino acid residue of the B chain or to the ε
-amino group of a Lys residue present in the B chain of the parent insulin, the side chain being of the general formula;
—
W—
X—
Y—
Zwherein W is two amino acid residues linked together via amide bonds, which chain—
via an amide bond—
is linked to the α
-amino group of the N-terminal amino acid residue of the B chain or to the ε
-amino group of a Lys residue present in the B chain of the parent insulin, the amino acid residues of W being selected from the group of amino acid residues having a neutral side chain and amino acid residues having a carboxylic acid group in the side chain so that W has at least one amino acid residue which has a carboxylic acid group in the side chain;X is —
CO—
;Y is —
(CH2)m—
where m is an integer in the range of 6 to 32; andZ is —
COOH;and any Zn2+complexes thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- -amino group of the N-terminal amino acid residue of the B chain or to the ε
Specification