Dispersive ultrasound technology as a diagnostic device for traumatic brain injuries

• US 8,834,376 B2
• Filed: 02/28/2012
• Issued: 09/16/2014
• Est. Priority Date: 02/28/2012
• Status: Active Grant

• Current Assignee: Her Majesty The Queen In Right of Canada As Represented By The Minister of National Defence
• Original Assignee: Her Majesty The Queen In Right of Canada As Represented By The Minister of Industry (The Republic of Canada)
• Inventors: Stergiopoulos, Stergios, Freibert, Andreas, Zhang, Jason
• Primary Examiner(s): Cwern, Jonathan
• Assistant Examiner(s): LAURITZEN, AMANDA L
• Application Number:
  US13/407,378
• Publication Number:
  US 20130225998A1
• Time in Patent Office: 931 Days
• US Class Current: 600/448
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 8/0808 for diagnosis of the brain
• CPC Class Codes: A61B 8/0858 involving measuring tissue layers, e.g. skin, interfaces
• CPC Class Codes: G01N 2291/048 Transmission, i.e. analysed material between transmitter and receiver

Abstract

Described herein is the use of ultrasound pulses at different frequencies to track the dispersion properties of intracranial tissues which may have been altered due to traumatic or other neurological brain injury. Dispersive ultrasound does not provide imaging, but it can provide data of significant diagnostic value by using decision support systems that can be trained as a medical diagnostic system for traumatic brain injuries applications to detect specific patterns of dispersion that are associated with specific intracranial injuries.

Claims

1. A method of classifying a medium comprising:

a) placing a transmitting transducer and a receiving transducer on opposite sides of a medium and traversing the medium with a plurality of frequency modulated ultrasound pulses between the transducers, each pulse being transmitted at a different frequency;

b) identifying, with a computer, a signal from one of the ultrasound pulses received by the receiving transducer by pulse duration, center frequency and bandwidth;

c) estimating propagation time through the medium for said signal using cross correlation with a replica of the transmitted pulse using the computer;

d) improving the estimate of the propagation time by determining when the phase of said signal changes sign by performing an interpolation based on a linear portion of the phase using the computer;

e) repeating steps (b)-(d) for each frequency of the plurality of ultrasound pulses;

f) using information derived from the plurality of ultrasound pulses to generate a dispersion pattern of the medium using the computer; and

g) using the computer to classify the medium based on characteristics of the dispersion pattern.

2. The method according to claim 1 including at step (b) applying a temporal window to one of the signals.

3. The method according to claim 1 wherein each pulse of the plurality of ultrasound pulses has a bandwidth of 0.5 MHz.

4. The method according to claim 1 including applying Finite Impulse Response (FIR) filters when estimating the propagation time.

5. The method according to claim 1 wherein when the phase of said signal changes sign is calculated by Hilbert transformation.

6. The method according to claim 1 wherein the dispersion pattern is compared to a database of dispersion patterns of known media and the medium is classified based on said comparison.

7. The method according to claim 6 wherein the database comparison is carried out by a support vector machine.

8. The method according to claim 1 wherein the medium is intracranial tissues.

9. The method according to claim 8 wherein frequencies of the plurality of ultrasound pulses are between 500 kHz and 10 MHz.

10. The method according to claim 8 wherein the medium is intracranial tissues which are suspected of having been altered by a brain injury.

11. The method according to claim 10 wherein frequencies of the plurality of ultrasound pulses are between 500 kHz and 10 MHz.