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Methods and compositions for increasing iduronate 2-sulfatase activity in the CNS

  • US 8,834,874 B2
  • Filed: 10/08/2010
  • Issued: 09/16/2014
  • Est. Priority Date: 10/09/2009
  • Status: Active Grant
First Claim
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1. A fusion antibody comprising:

  • (a) an immunoglobulin that crosses a blood brain barrier (BBB), wherein the immunoglobulin comprises an immunoglobulin heavy chain and an immunoglobulin light chain; and

    (b) an iduronate-2-sulfatase, wherein the amino acid sequence of the iduronate-2-sulfatase is covalently linked to the carboxy terminus of the amino acid sequence of the immunoglobulin heavy chain, thereby forming a fusion protein;

    wherein the fusion antibody crosses the blood brain barrier (BBB) and catalyzes hydrolysis of 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate or heparin and wherein the iduronate-2-sulfatase retains at least 20% of its activity compared to its activity as a separate entity.

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