Material encapsulation system

• US 8,834,934 B2
• Filed: 02/11/2004
• Issued: 09/16/2014
• Est. Priority Date: 02/11/2003
• Status: Expired due to Fees

• Current Assignee: Haviland Products Company (Haviland Enterprises, Inc.)
• Original Assignee: Haviland Products Company (Haviland Enterprises, Inc.)
• Inventors: Walls, John E., Putt, Jeffrey W., DeLine, Kenneth E.
• Primary Examiner(s): Heyer, Dennis
• Assistant Examiner(s): PODGORSKI, DANIEL MICHAEL
• Application Number:
  US10/544,586
• Publication Number:
  US 20060110464A1
• Time in Patent Office: 3,870 Days
• Field of Search: 424/490, 503/217, 510/130, 510/138
• US Class Current: 424/490
• CPC Class Codes: A61K 2800/26 Optical properties
• CPC Class Codes: A61K 2800/28 Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
• CPC Class Codes: A61K 2800/45 Colour indicators, e.g. pH- or Redox indicators
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/33 containing oxygen
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 9/5057 Gelatin
• CPC Class Codes: A61K 9/5073 having two or more different coatings optionally including drug-containing subcoatings
• CPC Class Codes: A61K 9/5084 Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs tablets containing such a mixture A61K9/2077
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations

Abstract

A material encapsulation and release system having a first zone (1) containing a first amount of material (2) bound by a first capsule wall (3) and, if desired, a second zone (4) containing a second amount of material (5) bound by a second capsule wall (6), each capsule wall responsive to similar or dissimilar activation means (7) to release the first amount of material (2) in the first zone (1) and the second amount of material (5) in the second zone (4).

Claims

1. A material release system, comprising:

a. a first amount of material, wherein said first amount of material comprises a base;

b. a capsule having a first capsule wall which bounds said first amount of material, wherein said capsule releases said first amount of material in response to a first activation element;

c. a liquid carrier having a pH of between about 5 and about 7 in which a plurality of said capsules are mixed, and wherein said plurality of capsules do not degrade in said liquid carrier; and

d. an amount of indicator material mixed into said liquid carrier, wherein release of said first amount of material in response to said first activation element increases said pH of said liquid carrier to greater than 7, and wherein said amount of indicator material dissolved into said liquid carrier changes color in response to increase in said pH.

2. A material release system as described in claim 1, wherein said base is selected from the group consisting of:

sodium acetate, sodium carbonate, sodium bicarbonate, sodium borate, sodium citrate, sodium folate, sodium hydroxide, sodium phosphate dibasic, sodium phosphate tribasic, sodium polymetaphosphate, sodium pyrophosphate, sodium glycerophosphate, sodium ortho silicate, sodium meta silicate, sodium hypochlorite, sodium metaborate, sodium perborate, sodium tartrate, trisodium phosphate, potassium salts thereof, and lithium salts thereof.

3. A material release system as described in claim 1, wherein said base comprises a base particle.

4. A material release system as described in claim 1, wherein said base comprises a trisodium phosphate.

5. A material release system as described in claim 4, wherein said trisodium phosphate comprises an anhydrous trisodium phosphate.

6. A material release system as described in claim 4, wherein said trisodium phosphate comprises a trisodium phosphate hydrated with five (5) moles of water.

7. A material release system as described in claim 4, wherein said trisodium phosphate comprises a trisodium phosphate hydrated with nine (9) moles of water.

8. A material release system as described in claim 4, wherein said trisodium phosphate comprises a trisodium phosphate hydrated with twelve (12) moles of water.

9. A material release system as described in claim 4, wherein said trisodium phosphate comprises a trisodium phosphate particle of between about 40 micron and about 250 micron.

10. A material release system as described in claim 4, wherein said trisodium phosphate comprises a trisodium phosphate particle of between about 40 micron and about 100 micron.

11. A material release system as described in claim 4, wherein said trisodium phosphate comprises a trisodium phosphate particle of between about 50 micron and about 80 micron.

12. A material release system as described in claim 4, wherein said trisodium phosphate comprises a plurality of trisodium phosphate particles sieved through a first United States standard mesh 200 and sieved through a second United States standard mesh 270 to provide said plurality of trisodium phosphate particles in the range of between United States standard mesh 200 and United States standard mesh 270.

13. A material release system as described in claim 1, wherein said carrier is selected from the group consisting of:

ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, poly(ethylene glycol/propylene glycol), 1,3-propanediol, 1,2-butanediol, 2,3-butanediol, 1,4-butanediol, 1,6-hexanediol, pinacol, glycerol, neopentylglycol, pentaerythritol, meso-hydrobenzoin, 1,2-cyclopentanediol, 1,2-cyclohexanediol, methanol, ethanol, isopropanol, n-propanol, n-butanol, isobutanol, sec-butanol, tert-butanol, n-pentanol, isopentanol, amyl alcohol, tert-pentanol, cyclopentanol, cyclohexanol, n-hexanol, n-heptanol, n-octanol, n-nonanol. n-decanol, n-dodecanol n-tetradecanol, n-hexadecanol, n-octadecanol, phenoxyethanol, benzyl alcohol, diphenyl carbinol, tetraphenylcarbinol, methoxyethanol, ethoxyethanol, propoxyethanol, butoxyethanol, hexoxyethanol, methoxypropanol, ethoxypropanol, propoxypropanol, butoxyepropanol, hexoxypropanol, ethoxyethoxy methanol, ethoxyethoxy ethanol, ethoxyethoxy propanol, ethoxyethoxy butanol, ethoxyethoxy hexanol, propoxypropoxy methanol, propoxypropoxy ethanol, propoxypropoxy propanol, propoxypropoxy butanol, propoxypropoxy hexanol.

14. A material release system as described in claim 13, wherein said amount of indicator material comprises a color change material.

15. A material release system as described in claim 14, wherein said amount of indicator material changes color in response to altered pH of said carrier.

16. A material release system as described in claim 15, wherein said amount of indicator material changes color in response to an increase in pH of said carrier.

17. A material release system as described in claim 16, wherein said amount of indicator is selected from the group consisting of:

brilliant yellow, bromothylmol blue, m-nitrophenol, neutral red, phenolphthalein.

18. A material release system as described in claim 17, wherein said carrier has a final pH of between about 7.0 and about 9.4.

19. A material release system as described in claim 18, wherein said carrier comprises a composition suitable as a hand wash agent wherein said capsule releases substantially all of said base not before elapse of about 10 seconds and not after elapse of about 30 seconds.