Azepine inhibitors of janus kinases
First Claim
Patent Images
1. A method of treating a disease associated with JAK activity in a patient, wherein said disease is allograft rejection, graft versus host disease, rheumatoid arthritis, psoriasis, polycythemia vera (PV), essential thrombocythemia (ET), or myeloid metaplasia with myelofibrosis, comprising administering to said patient a therapeutically effective amount of a compound of Formula Ia, Ib, or Ic:
3 Assignments
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Accused Products
Abstract
The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
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Citations
33 Claims
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1. A method of treating a disease associated with JAK activity in a patient, wherein said disease is allograft rejection, graft versus host disease, rheumatoid arthritis, psoriasis, polycythemia vera (PV), essential thrombocythemia (ET), or myeloid metaplasia with myelofibrosis, comprising administering to said patient a therapeutically effective amount of a compound of Formula Ia, Ib, or Ic:
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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2. The method of claim 1, wherein the compound is a compound having Formula Ia, or a pharmaceutically acceptable salt thereof.
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3. The method of claim 1, wherein the compound is a compound having Formula Ib, or pharmaceutically acceptable salt thereof.
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4. The method of claim 1, wherein the compound is a compound having Formula Ic, or pharmaceutically acceptable salt thereof.
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5. The method of claim 1, wherein E is NR2a.
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6. The method of claim 1, wherein E is NH or NOH.
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7. The method of claim 1, wherein G is N.
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8. The method of claim 1, wherein E is NH or NOH and G is N.
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9. The method of claim 1, wherein E is NH and G is N.
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10. The method of claim 1, wherein the compound is a compound having Formula Ia, or a pharmaceutically acceptable salt thereof, wherein:
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E is NH or NOH; and G is N.
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11. The method of claim 1, wherein Q1 is N and Q2 is CR2c.
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12. The method of claim 1, wherein Q1 is CR2c and Q2 is N.
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13. The method of claim 1, wherein each of D1, D2, and D3 is CR1.
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14. The method of claim 1, wherein each of D1, D2, and D3 is CH.
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15. The method of claim 1, wherein each of D4, D5, D6, and D7 is CR1.
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16. The method of claim 1, wherein each of D4, D5, and D7 is CR1 and D6 is N.
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17. The method of claim 1, wherein each of D4 and D7 is CH.
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18. The method of claim 1, wherein D5 is CR1 and R1 is H or halo.
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19. The method of claim 1, wherein D6 is CR1 and R1 is halo.
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20. The method of claim 1, wherein D6 is CF.
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21. The method of claim 1, wherein D6 is N.
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22. The method of claim 1, wherein D5 is CH or CF.
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23. The method of claim 1, wherein -W1-W2-W3-W4 is C1-6 alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl, each optionally substituted by 1, 2, or 3 halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 haloalkylcarbonyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, —
- COOH, —
COO—
(C1-4 alkyl), OH, C1-4 alkoxy, C1-4 haloalkoxy, hydroxyalkyl, CN, cyanoalkyl, alkylthio, arylthio, haloalkylthio, alkylsulfinyl, alkylsulfonyl, arylsulfinyl, arylsulfonyl, aryloxy, cycloalkyloxy, arylalkyloxy, aminocarbonyl, aminocarbonylalkyl, cyanoalkylcarbonyl, formyl, alkylcarbonyl, amino, alkylamino, alkylcarbonylamino, alkyloxycarbonylamino, or dialkylamino optionally substituted by CN.
- COOH, —
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24. The method of claim 1, wherein -W1-W2-W3-W4 is C1-6 alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heterocycloalkyl, or heterocycloalkylalkyl, each optionally substituted by 1, 2, or 3 halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 haloalkylcarbonyl, aryl, —
- COO—
(C1-4 alkyl), OH, C1-4 alkoxy, C1-4 haloalkoxy, hydroxyalkyl, CN, cyanoalkyl, alkylthio, haloalkylthio, alkylsulfinyl, alkylsulfonyl, arylalkyloxy, aminocarbonyl, aminocarbonylalkyl, cyanoalkylcarbonyl, formyl, alkylcarbonyl, alkyloxycarbonylamino, alkylcarbonylamino, or dialkylamino optionally substituted by CN.
- COO—
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25. The method of claim 1, wherein -W1-W2-W3-W4 is methyl, ethyl, propyl, butyl, pentyl, hexyl, phenyl, naphthyl, biphenyl, benzyl, phenylethyl, phenylpropyl, cyclopropyl, cyclohexyl, cyclohexenyl, bicyclo[2.2.1]hept-2-enyl, cyclopentyl, pyridyl, pyrryl, imidazolyl, isoxazolyl, thiazolyl, quinolinyl, piperidinyl, tetrahydrofuranyl, pyrrolidinyl, benzo [1,3]dioxolyl, (piperidin-4-yl)methyl, (piperidin-3-yl)methyl, (tetrahydropyran-4-yl)-methyl, (tetrahydrothiopyran-4-yl)-methyl, each optionally substituted by 1, 2, or 3 halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 haloalkylcarbonyl, aryl, —
- COO—
(C1-4 alkyl), OH, C1-4 alkoxy, C1-4 haloalkoxy, hydroxyalkyl, CN, cyanoalkyl, cyanoalkylcarbonyl, alkylthio, haloalkylthio, alkylsulfinyl, alkylsulfonyl, arylalkyloxy, aminocarbonyl, aminocarbonylalkyl, cyanoalkylcarbonyl, formyl, alkylcarbonyl, alkyloxycarbonylamino, alkylcarbonylamino, or dialkylamino optionally substituted by CN.
- COO—
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26. The method of claim 1, wherein -W1-W2-W3-W4 is phenyl, pyrazyl, pyrindyl, pyrryl, indolyl, furyl, thienyl, or benzothienyl, each optionally substituted by 1, 2, 3, 4, or 5 halo, C1-4 alkyl, C1-4 haloalkyl, aryl, OH, C1-4 alkoxy, hydroxyalkyl, CN, cyanoalkyl, alkylthio, haloalkylthio, alkylsulfinyl, alkylsulfonyl, cycloalkyl, heterocycloalkyl, cycloalkylakyl, heterocyclyoalkylalkyl, amino, dialkylamino, aminoalkyl, or aminosulfonyl.
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27. The method of claim 1, wherein -W1-W2-W3-W4 is phenyl optionally substituted by 1, 2, 3, 4, or 5 halo, C1-4 alkyl, C1-4 haloalkyl, aryl, OH, C1-4 alkoxy, hydroxyalkyl, CN, cyanoalkyl, alkylthio, haloalkylthio, alkylsulfinyl, alkylsulfonyl, cycloalkyl, heterocycloalkyl, cycloalkylakyl, heterocyclyoalkylalkyl, amino, dialkylamino, aminoalkyl, or aminosulfonyl.
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28. The method of claim 1, wherein -W1-W2-W3-W4 is phenyl optionally substituted by 1, 2, 3, 4, or 5 halo, C1-4 alkyl, C1-4 haloalkyl, aryl, OH, C1-4 alkoxy, CN, cyanoalkyl, alkylthio, or amino.
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29. The method of claim 1, wherein the compound is a compound having Formula IIa or IIb:
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30. The method of claim 1, wherein the compound is selected from:
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2-tert-butyl-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 2-cyclopropyl-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 2-cyclohexyl-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 10-fluoro-2-isobutyl-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 2-cyclopentyl-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 10-fluoro-2-(tetrahydrofuran-3-yl)-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 2-cyclohex-3-en-1-yl-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; Trans ethyl (1R,S)-2-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclopropanecarboxylate; 2-bicyclo[2.2.1]hept-5-en-2-yl-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; [(1S)-2-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclopropyl]methanol; 2-(1-ethylpentyl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 4-ethyl-4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)hexanenitrile; 2-cyclopentyl-10,11-difluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 2-(1-ethylpentyl)-10,11-difluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 3-[1-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclohexyl]propanenitrile; 4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)-4-methylpentanenitrile; 2-(1-ethylpropyl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 10-fluoro-2-[2-(methylthio)ethyl]-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 10-fluoro-2-[2-(methylsulfinyl)ethyl]-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 2-[(benzyloxy)methyl]-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; Cis-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclohexyl]methanol; Trans-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclohexyl]methanol; Cis-4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclohexanol; Trans-4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclohexanol; Trans-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclohexyl]acetonitrile; 2-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)cyclohexyl]acetamide; tert-butyl 4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)piperidine-1-carboxylate; 10-fluoro-2-piperidin-4-yl-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 3-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)piperidin-1-yl]-3-oxopropanenitrile; 2-(1-acetylpiperidin-4-yl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 10-fluoro-2-[1-(methylsulfonyl)piperidin-4-yl]-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; [4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)piperidin-1-yl]acetonitrile; ethyl [4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)piperidin-1-yl]acetate; 2-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)piperidin-1-yl]ethanol; 3-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)piperidin-1-yl]propan-1-ol; 4-[4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)piperidin-1-yl]butanenitrile; 10-fluoro-2-[3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 2-[3-(difluoromethyl)-5-methyl-1H-pyrazol-4-yl]-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 2-(3,5-dimethyl-1H-pyrazol-4-yl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 2-(3,5-diethyl-1H-pyrazol-4-yl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; [4-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetonitrile; 2-(2-chloro-6-methylphenyl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 2-(10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepin-2-yl)-3-methylbenzonitrile; 2-(2,6-dimethylphenyl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; 2-(3,5-dichloropyridin-4-yl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; and 2-(2,4-dimethylpyridin-3-yl)-10-fluoro-3,8-dihydroimidazo[4,5-d]pyrido[2,3-b][1]benzazepine; or a pharmaceutically acceptable salt thereof.
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31. The method of claim 1, wherein the compound is selected from:
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4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-4-ethylhexanenitrile;2-[4-(hydroxymethyl)-cyclohexyl]-imidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-3(8H)-ol;[4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)cyclohexyl]methanol;[4-(3-hydroxy-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)cyclohexyl]acetonitrile;[4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)cyclohexyl]acetonitrile;3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-3-methylbutanenitrile;3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-3-ethylpentanenitrile;[3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)cyclopentyl]acetonitrile;3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)cyclopentanecarbonitrile;2-(3,5-dichloropyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,6-dichlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,6-dimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-fluoro-6-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(6-chloro-2-fluoro-3-methylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2-fluoro-6-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-chloro-6-fluoro-3-methylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-chloro-6-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2-chloro-5-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,6-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,5-dichlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3,5-dibromopyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-bromophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-methylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-chlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-ethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,5-dimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2-chloro-3-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2,5-bis(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3-chloro-2,6-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,3-dichlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;3-[[4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-ylphenyl](ethyl)amino]propanenitrile;2-(2-chloro-3,6-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3-bromopyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(5-bromo-2,3-dimethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[3-chloro-2-fluoro-5-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3-chloropyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,3-dimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2-fluoro-3-(trifluoromethyl) phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3-fluoro-2-methylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(5-bromo-2-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2-fluoro-5-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-fluoro-3-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-fluoro-5-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,3-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-quinolin-4-yl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(5-fluoro-2-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(5-bromo-2-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,5-dimethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,5-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3,5-dimethyl-1H-pyrrol-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,6-dimethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(4-methyl-1H-imidazol-5yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-3,5-dimethoxyphenol;2-(2-pentafluoroethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(5-bromo-1,3-benzodioxo1-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-4-phenylpentanenitrile;2-[2-fluoro-4-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(cyclohexylmethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;3-bromo-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-6-methoxyphenol;2-(2-fluoropyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-biphenyl-2-yl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;methyl-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)benzoate;2-[2-(ethylthio)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(1H-pyrrol-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-{4-[(trifluoromethyl)thio]phenyl}-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-naphthyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;tert-butyl[1-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-2-phenethyl]carbamate;2-pyrrolidin-2-yl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-chloro-6-methoxyquinolin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(1-acetylpyrrolidin-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(1,3-thiazol-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;1-acetyl-5-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)pyrrolidin-3-ol;N-[1-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)ethyl]acetamide;tert-butyl 2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-4-hydroxypyrrolidine-1-carboxylate;N-[4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenyl]acetamide;2-[4-(difluoromethoxy)phenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(6-chloropyridin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;6-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-2(methylthio)nicotinonitrile;2-(3-fluoropyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(6-methoxypyridin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(6-bromopyridin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(6-bromopyridin-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(1H-imidazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2-(methylthio)ethyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(piperidin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;3-[4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)piperidin-1-yl]-3-oxopropanenitrile;3-[3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)piperidin-1-yl]-3-oxopropanenitrile;3-(4-((3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)methyl)piperidin-1-yl)-3-oxopropanenitrile;3-(3-((3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)methyl)piperidin-1-yl)-3-oxopropanenitrile;2-[1-(trifluoroacetyl)piperidin-4-yl]3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[1-(trifluoroacetyl)piperidin-3-yl]3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-{[1-(trifluoroacetyl)piperidin-4-yl]methyl}-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-{[1-(trifluoroacetyl)piperidin-3-yl]methyl}-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(1-acetylpiperidin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)piperidine-1-carbaldehyde;2-[(1-acetylpiperidin-4-yl)methyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[(1-acetylpiperidin-3-yl)methyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(1-methylpiperidin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)benzonitrile;4-(3-hydroxy-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)benzonitrile;3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)benzonitrile;2-pyridin-3-yl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-pyridin-3-ylimidazo [4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-3(8H)-ol;2-pyridin-2-ylimidazo [4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-3(8H)-ol;2-pyridin-4-yl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-pyridin-4-ylimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-3(8H)-ol;2-piperidin-3-yl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[4-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[6-(trifluoromethyl)pyridine-3-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[3-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3,5-dimethylisoxazol-4-yl)imidazo [4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-3(8H)-ol;2-[4-(methylthio)phenyl]-3,8- dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[4-(methylthio)phenyl]imidazo [4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-3(8H)-ol;2-[4-(methylsulfonyl)phenyl]-3,8- dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(1H-imidazol-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(1-methyl-1H-imidazol-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-phenyl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-phenylimidazo [4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-3(8H)-ol;2-benzyl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-benzylimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-3(8H)-ol;2-(2-phenethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-phenethyl)imidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-3(8H)-ol;2-piperidin-4-yl-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-piperidin-4-yl imidazo [4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-3(8H)-ol;2-(piperidin-4-ylmethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(piperidin-4-ylmethyl)imidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-3(8H)-ol;2-(piperidin-3-ylmethyl)-3,8- dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(tetrahydro-2H-pyran-4-ylmethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(tetrahydro-2H-pyran-4-ylmethyl)imidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-3(8H)-ol;2-(tetrahydro-2H-thiopyran-4-ylmethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(tetrahydro-2H-thiopyran-4-ylmethyl)imidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-3(8H)-ol;2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[3-(difluoromethyl)-5-methyl-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[1-(4-methoxybenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[1-ethyl-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[1-(cyclopropylmethyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[3-methyl-5-(pentafluoroethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-N,N,5-trimethyl-3-(trifluoromethyl)-1H-pyrazole-1-sulfonamide;2-[3-[chloro(difluoro)methyl]-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[3-(difluoromethyl)-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3,5-dimethyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3-isobutyl-5-methyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3-ethyl-5-methyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3-butyl-5-methyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3,5-diethyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(5-cyclopropyl-3-methyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-chloro-6-methylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-3-methylbenzonitrile;2-(2,4-dimethyl-3-thienyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[4-methylsulfinyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[4-(ethylthio)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2-(5-methyl-2-furyl)propyl]-3,8-dihydroimidazo[4 ,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(1-benzothien-5-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,4-dimethyl-1,3-thiazol-5-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3-f]azepine;2-(5-methyl-3-phenylisoxazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(4-chloro-1-methyl-1H-pyrazol-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3,5-dimethylisoxazol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[1-(2-methoxyethyl)-2,5-dimethyl-1H-pyrrol-3-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(1-cyclopropyl-2,5-dimethyl-1H-pyrrol-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2,5-dimethoxy-4-(methylthio)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(trifluoromethyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,4-dimethoxy-3-methylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2-(methylthio)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-ethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,4-dimethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,3,4,5,6-pentamethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-chloro-4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-methyl-4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenol;2-(2,5-dimethyl-4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-chloro-3,4-dimethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,3-dimethyl-4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,6-dichloro-3,4-dimethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2,4-dichloro-3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-6-methoxyphenol;2-(2,4,5-trimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,4-dichlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-chloro-4-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,4-dimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2-(trifluoromethoxy)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2-(difluoromethoxy)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-methoxypyridin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[4-fluoro-2-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,4,6-trimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-chloro-3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-6-methoxyphenol;2-(3-methylpyridin-2-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-3-ethoxy-N,N-diethylaniline;2-(2,5-dimethoxy-4-bromophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-isobutoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)pyridine-2-amine;2-(1H-indol-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-{2-[(trifluormethyl)thio]phenyl}-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;4-bromo-3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenol;2-[2-chloro-4-(methylsulfonyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,2-difluoro-1,3-benzodioxo1-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-3,5-dimethylphenol;2-(2-chloro-4,6-dimethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3-chlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[3-fluoro-5-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3,5-dichlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3-chloro-4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(6-chloro-1,3-benzodioxol-5-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(4-chloro-2,6-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(6-chloro-2,3-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,6-dichloro-3-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-chloro-6-fluoro-3-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,4,6-trifluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2-methoxy-4-(trifluoromethoxy)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3-chloro-4-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(4-fluoro-2-methylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,4-dichloro-6-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,6-dichloro-3-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,6-dichloro-4-methylthiophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2,6-dichloro-4-(methylsulfinyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2,6-dichloro-4-(methylsulfonyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(6-chloro-2-fluoro-3-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-chloro-6-fluoro-4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenyl]methanol;[3,5-difluoro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenyl]methanol;3,5-dichloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenol;5-chloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)nicotinonitrile;4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)pyridine-3,5-dicarbonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-3-fluoro-6-methylbenzonitrile;4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)nicotinonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-3,6-difluorobenzonitrile;3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-2-fluoro-4-(trifluoromethyl)benzonitrile;3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-4-methoxybenzonitrile;6-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-2,3-dimethoxybenzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-4,5-dimethoxyisophthalonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-4-hydroxy-5-methoxyisophthalonitrile;4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-2,5-dimethoxybenzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-(methylsulfonyl)benzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-3,5-dimethoxybenzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-3,5-difluorobenzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-3,4-difluorobenzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-3-fluoro-6-methoxybenzonitrile;5-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-2-fluorobenzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-3-fluoro-4-methoxybenzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-3-fluoro-5-methoxybenzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-(methylthio)isophthalonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-(hydroxymethyl)isophthalonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-(hydroxymethyl)benzonitrile;[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenyl]acetonitrile;5-(cyanomethyl)-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)isophthalonitrile;5-(cyanomethyl)-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)benzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-(methylsulfinyl)benzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)5-(methylsulfonyl)isophthalonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-hydroxybenzonitrile;1-[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenyl]-N,N-dimethylmethanamine;2-[2,6-dichloro-4-(morpholin-4-ylmethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2,6-dichloro-4-(thiomorpholin-4-ylmethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2,6-dichloro-4-(methoxymethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2,6-dichloro-4-(ethylthio)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2,6-dichloro-4-(isopropylthio)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2,6-dichloro-4-(ethylsulfinyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2,6-dichloro-4-(ethylsulfonyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2,6-dichloro-4-(isopropylsulfinyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2,6-dichloro-4-(isopropylsulfonyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-(isopropylsulfonyl)benzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-(ethylthio)isophthalonitrile;3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-(ethylthio)benzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-(isopropylthio)isophthalonitrile;3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-(isopropylthio)benzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-(isopropylsulfinyl)isophthalonitrile;3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-(isopropylsulfinyl)benzonitrile;2-[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenoxy]acetonitrile;2-[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenoxy]propanenitrile;5-(1-cyanoethoxy)-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)isophthalonitrile;5-(1-cyanoethoxy)-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)benzonitrile;5-(cyanomethoxy)-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)isophthalonitrile;2-[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenoxy]propanamide;2-[3,5-dicyano-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenoxy]propanamide;5-(2-amino-1-methyl-2-oxoethoxy)-3-cyano-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)benzamide;5-(2-amino-1-methyl-2-oxoehtoxy)-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)isophthalamide;2-[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenoxy]acetamide;2-[3,5-dicyano-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenoxy]acetamide;2-cyano-2-[3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenoxy]-N,N-dimethylacetamide;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)isophthalonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)benzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-4-hydroxybenzonitrile;4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-1,3-benzodioxole-5-carbonitrile;3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)benzonitrile;3-fluoro-4-methyl-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)benzonitrile;3-fluoro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)benzonitrile;3-methoxy-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)benzonitrile;5-fluoro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)benzonitrile;3-chloro-6-methoxy-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)benzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-4-methoxyisophthalonitrile;tert-butyl [4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)pyridine-3-yl]carbamate;tert-butyl [4-(3-hydroxy-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)pyridin-3-yl]carbamate;2-(3,5-dimethylpyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)phenol;2-(2,6-dichloro-4-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,6-dichloro-4-ethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,6-dichloro-4-isopropoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2,6-dichloro-4-(trifluoromethoxy)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(3-methylpyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2-methylpyridin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,4-dimethylpyridin-3-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(5-chloro-2-ethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(5-chloro-2-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(5-bromo-2-ethoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-(2,3-difluoro-6-methoxyphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;3,5-dichloro-4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-N,N-dimethylaniline;2-(2,6-dichloro-4-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepine;3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-methoxybenzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-methoxyisophthalonitrile;3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-ethoxybenzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-ethoxyisophthalonitrile;3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-isopropoxybenzonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-isopropoxyisophthalonitrile;2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
3′
4]azepin-2-yl)-5-(trifluoromethoxy)isophthalonitrile;3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-(trifluoromethyl)benzonitrile;3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-(dimethylamino)benzonitrile; and3-chloro-2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
4′
,3′
-f]azepin-2-yl)-5-fluorobenzonitrile;or a pharmaceutically acceptable salt thereof.
-
-
32. The method of claim 1, wherein the compound is selected from:
-
2-(3,5-dichloropyridin-4-yl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepine;2-(2,6-dichlorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepine;2-(2,6-difluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepine;2-(2-chloro-6-fluorophenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepine;2-(2,6-dimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepine;4-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepin-2-yl)-4-ethylhexanenitrile;2-[1-(4-methoxybenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]imidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepin-3(8H)-ol;2-[1-(4-methoxybenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepine;2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]imidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepin-3(8H)-ol;2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepine;2-(2,3-dimethylphenyl)imidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepin-3(8H)-ol;2-(2,3-dimethylphenyl)-3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepine;2-[2-(dimethylamino)-pyridin-3-yl]imidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepin-3(8H)-ol;3-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepin-2-yl)-N,N-dimethylpyridin-2-amine; and2-(3,8-dihydroimidazo[4,5-d]dipyrido[2,3-b;
3′
,4′
-f]azepin-2-yl)-3-fluorobenzonitrile;or a pharmaceutically acceptable salt thereof.
-
-
33. The method of claim 1, wherein the compound is 2-(2,6-dichlorophenyl)-2,8-dihydropyrazolo[3,4-d]dipyrido[2,3-b:
- 3′
,4′
-f]azepine, or pharmaceutically acceptable salt thereof.
- 3′
-
2. The method of claim 1, wherein the compound is a compound having Formula Ia, or a pharmaceutically acceptable salt thereof.
Specification
- Resources
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Current AssigneeIncyte Holdings Corporation And Incyte Corporation
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Original AssigneeIncyte Corporation
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InventorsArvanitis, Argyrios G., Rodgers, James D., Combs, Andrew P., Sparks, Richard B., Robinson, Darius J.
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Primary Examiner(s)Aulakh, Charanjit
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Application NumberUS14/032,629Publication NumberTime in Patent Office361 DaysField of Search514/215, 435/184US Class Current514/215CPC Class CodesA61P 1/04 for ulcers, gastritis or re...A61P 11/00 Drugs for disorders of the ...A61P 13/12 of the kidneysA61P 17/00 Drugs for dermatological di...A61P 17/02 for treating wounds, ulcers...A61P 17/04 AntipruriticsA61P 17/06 AntipsoriaticsA61P 19/02 for joint disorders, e.g. a...A61P 21/04 for myasthenia gravisA61P 25/00 Drugs for disorders of the ...A61P 27/02 Ophthalmic agentsA61P 29/00 Non-central analgesic, anti...A61P 3/10 for hyperglycaemia, e.g. an...A61P 31/12 AntiviralsA61P 31/14 for RNA virusesA61P 31/18 for HIVA61P 31/20 for DNA virusesA61P 31/22 for herpes virusesA61P 35/00 Antineoplastic agentsA61P 35/02 specific for leukemiaA61P 35/04 : specific for metastasisA61P 37/00 : Drugs for immunological or ...A61P 37/02 : ImmunomodulatorsA61P 37/06 : Immunosuppressants, e.g. dr...A61P 37/08 : Antiallergic agents antiast...A61P 43/00 : Drugs for specific purposes...A61P 5/14 : of the thyroid hormones, e....A61P 9/10 : for treating ischaemic or a...C07D 471/14 : Ortho-condensed systemsC07D 471/22 : in which the condensed syst...C07D 487/14 : Ortho-condensed systemsC07D 487/22 : in which the condensed syst...