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Azepine inhibitors of janus kinases

  • US 8,835,423 B2
  • Filed: 09/20/2013
  • Issued: 09/16/2014
  • Est. Priority Date: 09/22/2005
  • Status: Active Grant
First Claim
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1. A method of treating a disease associated with JAK activity in a patient, wherein said disease is allograft rejection, graft versus host disease, rheumatoid arthritis, psoriasis, polycythemia vera (PV), essential thrombocythemia (ET), or myeloid metaplasia with myelofibrosis, comprising administering to said patient a therapeutically effective amount of a compound of Formula Ia, Ib, or Ic:

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