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Atlas-based analysis for image-based anatomic and functional data of organism

  • US 8,838,201 B2
  • Filed: 06/22/2011
  • Issued: 09/16/2014
  • Est. Priority Date: 06/22/2010
  • Status: Active Grant
First Claim
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1. A non-invasive imaging system, comprising:

  • an imaging scanner configured to generate an imaging signal from a tissue region of a subject under observation, the tissue region having at least one anatomical substructure and more than one constituent tissue type;

    a signal processing system in communication with said imaging scanner configured to receive the imaging signal from said imaging scanner; and

    a data storage unit in communication with said signal processing system,wherein said data storage unit is configured to store a parcellation atlas comprising spatial information of said at least one anatomical substructure in the tissue region,wherein said signal processing system is adapted to;

    reconstruct an image of said tissue region based on said imaging signal;

    parcellate, based on the parcellation atlas, the at least one anatomical substructure in said image;

    segment the more than one constituent tissue type in said image to provide a plurality of segmented constituent tissue types, wherein the parcellation atlas includes at least one of imaging data (i) of the more than one constituent tissue type, (ii) of at least one of a plurality of imaging modalities and a plurality of imaging contrasts corresponding to one subject, and (iii) corresponding to a plurality of subjects;

    automatically identify, in said image, a portion of the at least one anatomical substructure that corresponds to one of the more than one constituent tissue type; and

    average all image voxels in the identified constituent tissue type to increase a signal-to-noise ratio of the automatically identified portion,wherein averaging the image voxels at least one of increases image resolution of said image and decreases scanning time from said imaging scanner, andwherein the at least one anatomical substructure is defined in one of the image modalities or imaging contrasts which has a higher signal-to-noise or resolution and applied to other image modalities or imaging contrasts.

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