Systems, devices, and methods including paramagnetic oscillation, rotation and translation of hemozoin asymmetric nanoparticles in response to multi-harmonic optical detection of the presence of hemozoin
First Claim
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1. An apparatus, comprising:
- an actively-controllable magnetic field generator configured to deliver a varying magnetic field stimulus at a dose sufficient to cause heat generation from hemozoin nanoparticles within a biological sample; and
a controller operatively coupled to the actively-controllable magnetic field generator, the controller including one or more processors for controlling at least one of a magnetic field ON duration, a magnetic field strength, a magnetic field frequency, and a magnetic field waveform;
wherein the controller includes one or more processors for generating a control signal associated with actively controlling a polarization of a generated magnetic field.
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Abstract
Systems, devices, and methods are described for providing a monitor/treatment device configured to, for example, detect hemozoin, as well as to monitor or treat a malarial infection.
84 Citations
17 Claims
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1. An apparatus, comprising:
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an actively-controllable magnetic field generator configured to deliver a varying magnetic field stimulus at a dose sufficient to cause heat generation from hemozoin nanoparticles within a biological sample; and a controller operatively coupled to the actively-controllable magnetic field generator, the controller including one or more processors for controlling at least one of a magnetic field ON duration, a magnetic field strength, a magnetic field frequency, and a magnetic field waveform; wherein the controller includes one or more processors for generating a control signal associated with actively controlling a polarization of a generated magnetic field.
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2. An apparatus, comprising:
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an actively-controllable magnetic field generator configured to deliver a varying magnetic field stimulus at a dose sufficient to cause heat generation from hemozoin nanoparticles within a biological sample; a controller operatively coupled to the actively-controllable magnetic field generator, the controller including one or more processors for controlling at least one of a magnetic field ON duration, a magnetic field strength, a magnetic field frequency, and a magnetic field waveform and a sensor component configured to detect a nonlinear multi-harmonic response profile associated with hemozoin nanoparticles interrogated by an electromagnetic energy stimulus, and configured to compare the detect nonlinear multi-harmonic response profile to one or more reference hemozoin nonlinear response profiles. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A system for modulating plasmodium parasitic activity, comprising:
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circuitry configured to generate a magnetic field stimulus of a character and for a duration sufficient to elicit hemozoin nanoparticles within a biological sample to deliver magnetically induced hyperthermia therapy in vivo; and circuitry configured to dynamically control the magnetic field stimulus; wherein the circuitry configured to generate the electromagnetic field stimulus includes one or more conductive traces configured to generating a magnetic field in the presence of an applied potential. - View Dependent Claims (14, 15, 16)
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17. A system for modulating plasmodium parasitic activity, comprising:
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circuitry configured to generate a magnetic field stimulus of a character and for a duration sufficient to elicit hemozoin nanoparticles within a biological sample to deliver magnetically induced hyperthermia therapy in vivo; circuitry configured to dynamically control the magnetic field stimulus; and at least one of a transmitter, a receiver, and a transceiver configured to acquire magnetization-induced nonlinear optical response information emitted by the biological sample.
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Specification