Hydrogel based device for detecting an environmental state

• US 8,840,839 B2
• Filed: 04/02/2008
• Issued: 09/23/2014
• Est. Priority Date: 04/05/2007
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Iordanov, Ventzeslav Petrov, Krijnsen, Hendrika Cecilia, Van Bruggen, Michel Paul Barbara, Janner, Anna-Maria, Kurt, Ralph
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): LEE, WENG WAH
• Application Number:
  US12/593,305
• Publication Number:
  US 20100114072A1
• Time in Patent Office: 2,365 Days
• Field of Search: 600/32, 600573-584, 600322-341, 356/436, 435/14, 436 63- 70, 422 62- 98, 422400-430, 422 50- 54, 422500-570
• US Class Current: 422/82.05
• CPC Class Codes: A61B 5/0008 Temperature signals
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/4839 combined with drug delivery

Abstract

A transducer device for detecting an environmental state within a biological material including a channel comprising a fluid, a hydrogel material, which is adapted to change its volume when getting into contact with an environmental material and/or when detecting an environmental change, and which is mechanically coupled to the channel such that the volume of the channel changes when the volume of the hydrogel material changes. The transducer device further includes a sensor, which is adapted to generate a signal upon detection of the change of a physical property of the fluid that is induced by the volume change of the channel. By applying the transducer device, an accurate monitoring of physiological parameters, for which the hydrogel material is sensitive is possible. It is also possible to apply the transducer device outside of the bodily lumen, for example to monitor the blood of a patient outside the bodily lumen.

Claims

1. A transducer device for detecting an environmental state within a biological material, the transducer device comprising:

a channel comprising a liquid;

a hydrogel material, adapted to change its volume when getting into contact with the biological material and/or when detecting a change in the environmental state of the biological material, and which is mechanically coupled to the channel such that the volume of the channel changes when the volume of the hydrogel material changes;

a light source adapted to radiate light into the channel; and

a sensor adapted to generate a signal upon detection of the change in a physical property of the liquid that is induced by the volume change of the channel.

2. The transducer device as claimed in claim 1, wherein the sensor is adapted to measure a change in the pressure and/or the flow of the liquid in the channel.

3. The transducer device as claimed in claim 1, wherein the sensor is adapted to measure a change in the optical properties of the liquid in the channel.

4. The transducer device as claimed in claim 1, comprising a substrate in which the sensor is integrated, and on which substrate the channel and the hydrogel material are formed.

5. The transducer device as claimed in claim 1, wherein the light source is integrated in the substrate.

6. The transducer device as claimed in claim 1, further comprising an electronic circuit in electrical contact with the sensor.

7. The transducer device as claimed in claim 1, further comprising a transmitter unit, which is adapted to communicate with an external receiving unit.

11. The transducer device according to claim 1, wherein the transducer device is adapted as a diagnostic device.

12. The transducer device according to claim 11, wherein the diagnostic device is adapted for in vitro analysis of the liquid and further comprises an entry port and an outlet for the liquid.

8. A method for detecting an environmental state within a biological material, by means of a transducer device comprising a hydrogel material and a channel comprising a liquid, the method comprising acts of:

getting the transducer device into contact with the biological material, such that a hydrogel material changes its volume such that the volume of the channel changes;

radiating light from a light source into the channel; and

generating a signal upon detection of a change in a physical property of the liquid that is induced by the change of the volume of the channel.

9. A method for detecting an environmental state within a biological material, by means of a transducer device comprising a hydrogel material and a channel comprising a liquid, the method comprising acts of:

radiating light from a light source into the channel;

getting the transducer device into contact with the biological material, such that a hydrogel material changes its volume such that the volume of the channel changes;

generating a signal upon detection of the change of the optical properties of the liquid that is induced by the change of the volume of the channel.

10. A medical system comprising:

a transducer device for detecting an environmental state within a biological material, the transducer device comprising;

a channel comprising a liquid;

a hydrogel material, adapted to change its volume when getting into contact with the biological material and/or when detecting a change in the environmental state of the biological material, and which is mechanically coupled to the channel such that the volume of the channel changes when the volume of the hydrogel material changes;

a light source adapted to radiate light into the channel;

a sensor, which is adapted to generate a signal upon detection of the change in a physical property of the liquid that is induced by the volume change of the channel, and a drug release device, coupled to the transducer device and adapted to release a certain amount of drug when being triggered by the signal of the transducer device.