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Body cavity foams

  • US 8,840,869 B2
  • Filed: 04/28/2005
  • Issued: 09/23/2014
  • Est. Priority Date: 10/25/2002
  • Status: Active Grant
First Claim
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1. A device for administration of a foamable composition into a body cavity, comprising an aerosol container, a valve, an insert applicator and a foamable composition for application into said body cavity, which upon release from said aerosol container provides an expanded foam suitable for topical administration;

  • wherein the foamable composition comprises a propellant and a therapeutic composition being substantially free of lower alcohols wherein the therapeutic composition comprises;

    at least one organic carrier selected from a hydrophobic organic carrier, an emollient, a polar solvent, and mixtures thereof, at a concentration of about 70% to about 99% by weight of the therapeutic composition;

    at least one surface active agent at a concentration of about 0.2% to about 5% by weight of the therapeutic composition;

    at least one active agent; and

    at least one polymeric gelling agent at a concentration of about 0.01% to about 5% by weight of the therapeutic composition;

    wherein the propellant is a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the foamable composition;

    wherein the surface active agent is a non-ionic surface active agent or a mixture of at least one non ionic surface active agent and at least one ionic surface active agent in a ratio of about 20;

    1 or greater than 20;

    1.wherein upon release from the container the composition forms a breakable foam that collapses upon application of shear force; and

    wherein the breakable foam stays stable as a foam for at least about 3 minutes at about 37°

    C. after being dispensed from the container.

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