Method of making anti-microbial polymeric surfaces

• US 8,840,927 B2
• Filed: 02/26/2002
• Issued: 09/23/2014
• Est. Priority Date: 02/28/2001
• Status: Expired due to Fees

• Current Assignee: Covalon Technologies Incorporated
• Original Assignee: Covalon Technologies Incorporated
• Inventors: DiTizio, Valerio, DiCosmo, Frank
• Primary Examiner(s): Vu, Jake
• Application Number:
  US10/468,438
• Publication Number:
  US 20040086568A1
• Time in Patent Office: 4,592 Days
• Field of Search: 424/486, 424/618
• US Class Current: 424/486
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

The present invention is a method for the modification of the surfaces of polymeric materials with polymer coatings that may be subsequently treated to be lubricious and anti-microbial. The method comprises incubating a photo-initiator-coated polymeric material with an aqueous monomer that is capable of free radical polymerization and exposing the incubating polymeric material to UV light creating a modified surface on said polymeric material. The method may additionally comprise adding a silver component to the modified surface. The silver component may be provided as a silver salt coating or a silver salt contained within a hydrogel bonded to the acrylate modified polymeric material surface.

Claims

1. An anti-microbial polymeric composite comprising:

a polymeric body made of a polymeric material selected from the group consisting of polyurethanes, polyamides, polyesters, polyethers, polyorganosiloxanes, polysulfones, polytetrafluoroethylene and polysiloxanes, said polymeric body having a stable hydrophilic polyacrylate coating permanently grafted to the surface of the polymeric body, said coating being ionized and then cation saturated to render it lubricious, and said coating having a silver agent that is released from said polyacrylate coating slowly and continuously for a long and effective period of time.

2. The polymeric composite of claim 1, wherein said polymeric material is polysiloxane and said polysiloxane is silicone.

3. The polymeric composite of claim 2, wherein said polymeric material is provided as a device selected from the group consisting of implants, catheters, stents, wound dressings, cardiac valves, tubings, pins and clips.

4. The polymeric composite of claim 3, wherein said silver agent comprises a silver salt selected from the group consisting of silver lactate, silver phosphate, silver citrate, silver acetate, silver benzoate, silver chloride, silver carbonate, silver iodide, silver iodate, silver nitrate, silver laurate, silver sulfadiazine, silver palmitate and mixtures thereof.

5. The polymeric composite of claim 4, wherein said stable polyacrylate coating is made by the free radical polymerization of a monomer selected from the group consisting of acrylic acid, methacrylic acid, 2-carboxyethyl acrylate, 4-vinylbenzoic acid, itaconic acid, and mixtures thereof.

10. The composite of claim 1, wherein said coating is ionized using an aqueous base solution.

11. The composite of claim 10, wherein said cations are provided by a solution selected from the group consisting of sodium lactate, sodium citrate, disodium phosphate, potassium lactate, potassium citrate, dipotassium phosphate and mixtures thereof.

12. The composite of claim 1, wherein said lubricious coating is maintained when said composite is clinically used in vivo.

13. The composite of claim 2, wherein said silicone is silicone rubber.

6. An anti-microbial polymeric composite comprising:

a polymeric body made of a polymeric material of silicone, said polymeric body having a stable hydrophilic polyacrylate coating permanently grafted to the surface of the polymeric body, said coating being ionized and then cation saturated to render it lubricious, and said coating having a silver agent that comprises a silver salt selected from the group consisting of silver lactate, silver phosphate, silver citrate, silver acetate, silver benzoate, silver chloride, silver carbonate, silver iodide, silver iodate, silver nitrate, silver laurate, silver sulfadiazine, silver palmitate and mixtures thereof.

9. The composite of claim 6 or 7, wherein said lubricious coating is maintained when said composite is clinically used in vivo.

14. The composite of claim 6, wherein said silicone is silicone rubber.

7. An anti-microbial polymeric composite comprising:

a polymeric body made of a polymeric material selected from the group consisting of polyurethanes, polyamides, polyesters, polyethers, polyorganosiloxanes, polysulfones, polytetrafluoroethylene and polysiloxanes,

said polymeric body is provided as a device selected from the group consisting of implants, catheters, stents, wound dressings, cardiac valves, tubings, pins and clips,

said polymeric body having a stable hydrophilic polyacrylate coating permanently grafted to the surface of the polymeric body, said coating being ionized and then cation saturated to render it lubricious, and said coating having a silver agent that comprises a silver salt selected from the group consisting of silver lactate, silver phosphate, silver citrate, silver acetate, silver benzoate, silver chloride, silver carbonate, silver iodide, silver iodate, silver nitrate, silver laurate, silver sulfadiazine, silver palmitate and mixtures thereof.

8. The composite of claim 7, wherein said stable polyacrylate coating is made by the free radical polymerization of a monomer selected from the group consisting of acrylic acid, methacrylic acid, 2-carboxyethyl acrylate, 4-vinylbenzoic acid, itaconic acid, and mixtures thereof.

15. The composite of claim 7, wherein said wherein said polymeric material is polysiloxane and said polysiloxane is silicone rubber.