Systems and methods for conducting animal studies
First Claim
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1. A method, comprising:
- a) providing a cartridge comprising at least one sample collection unit and an assay assembly comprising a plurality of reaction sites each having a reactant contained therein;
b) reacting a first sample of biological fluid of less than about 50 ul from a subject with the reactants contained within the reaction sites of said assay assembly, wherein said assay assembly yields detectable signals generated from a plurality of analytes in the first sample that are indicative of concentrations of the plurality of analytes;
c) detecting said detectable signals with a reader assembly;
d) comparing said concentrations of said plurality of analytes with stored pharmacological data according to a bioinformatics model at an external device;
e) repeating over the course of a preclinical study the reaction and detection steps with at least a second sample of biological fluid from the same subject collected at a different time from the first sample; and
wherein said reacting step (b) occurs in accordance with a protocol transmitted from said external device that is external to the reader; and
wherein said protocol is selected by determining a plurality of protocols associated with the cartridge, and based on information about the subject, selecting one of said plurality of protocols associated with the cartridge to be run to detect said analytes.
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Abstract
This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.
197 Citations
26 Claims
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1. A method, comprising:
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a) providing a cartridge comprising at least one sample collection unit and an assay assembly comprising a plurality of reaction sites each having a reactant contained therein; b) reacting a first sample of biological fluid of less than about 50 ul from a subject with the reactants contained within the reaction sites of said assay assembly, wherein said assay assembly yields detectable signals generated from a plurality of analytes in the first sample that are indicative of concentrations of the plurality of analytes; c) detecting said detectable signals with a reader assembly; d) comparing said concentrations of said plurality of analytes with stored pharmacological data according to a bioinformatics model at an external device; e) repeating over the course of a preclinical study the reaction and detection steps with at least a second sample of biological fluid from the same subject collected at a different time from the first sample; and wherein said reacting step (b) occurs in accordance with a protocol transmitted from said external device that is external to the reader; and wherein said protocol is selected by determining a plurality of protocols associated with the cartridge, and based on information about the subject, selecting one of said plurality of protocols associated with the cartridge to be run to detect said analytes. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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2. A method, comprising:
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a) providing a cartridge comprising at least one sample collection unit and an assay assembly comprising a plurality of reaction sites each having a reactant contained therein; b) reacting a first sample of biological fluid of less than about 50 ul from said subject with the reactants contained within the reaction sites of said assay assembly, wherein said assay assembly yields detectable signals generated from a plurality of analytes that are indicative of concentrations of the plurality of analytes; c) detecting said detectable signals with a reader assembly; d) repeating the reaction and detection steps with a second sample of biological fluid from the same subject; and wherein said reacting step (b) occurs in accordance with a protocol transmitted from an external device that is external to the reader assembly, to yield a detectable signal indicative of the presence of said plurality of analytes, and wherein said protocol is selected by detecting an identifier on said cartridge and selecting the protocol to be run on said cartridge from a plurality of protocols associated with said identifier.
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Specification