Hybrid target analyte responsive polymer sensor with optical amplification
First Claim
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1. A product comprising:
- an optical sensor;
a target-responsive hydrogel matrix on a surface of the optical sensor, wherein the hydrogel matrix comprises one or more target-specific receptors and one or more target analogs; and
one or more high refractive index nanoparticles within the hydrogel matrix;
wherein a detectable change occurs in a refractive index of the hydrogel matrix when contacted with one or more target molecules.
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Abstract
Disclosed is a product that includes an optical sensor; a target-responsive hydrogel matrix on a surface of the optical sensor (where the hydrogel matrix comprises one or more target-specific receptors and one or more target analogs), and one or more high refractive index nanoparticles within the hydrogel matrix, where a detectable change occurs in a refractive index of the hydrogel matrix when contacted with one or more target molecules. Sterile packages and detection devices containing the product, and methods of detecting a target molecule using the product, are also disclosed.
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Citations
44 Claims
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1. A product comprising:
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an optical sensor; a target-responsive hydrogel matrix on a surface of the optical sensor, wherein the hydrogel matrix comprises one or more target-specific receptors and one or more target analogs; and one or more high refractive index nanoparticles within the hydrogel matrix; wherein a detectable change occurs in a refractive index of the hydrogel matrix when contacted with one or more target molecules. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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Specification