Sensing rate of change of pressure in the left ventricle with an implanted device

• US 8,845,544 B2
• Filed: 09/11/2013
• Issued: 09/30/2014
• Est. Priority Date: 06/01/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Carlson, Gerrard M., Siejko, Krzysztof Z., Wariar, Ramesh, Brockway, Marina V.
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Morales, Jon Eric C
• Application Number:
  US14/024,363
• Publication Number:
  US 20140018690A1
• Time in Patent Office: 384 Days
• Field of Search: None
• US Class Current: 600/528
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 7/00 Instruments for auscultation
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone
• CPC Class Codes: A61N 1/375 Constructional arrangements, e.g. casings
• CPC Class Codes: A61N 1/37512 Pacemakers

Abstract

An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.

Claims

1. A device comprising:

a transducer configured to convert an acceleration correlative to a S1 heart sound into an electrical signal; and

a control circuit coupled to the transducer, the control circuit configured to;

receive the electrical signal;

identify the acceleration correlative to the S1 heart sound;

determine a patient status indicator using information related to the acceleration correlative to the S1 heart sound;

wherein the patient status indicator indicates at least one of contractility or a maximum time rate of change of pressure within a ventricle of a heart during a cardiac cycle; and

wherein the device is configured to detect an auxiliary physiological signal in conjunction with detection of the acceleration correlative to the S1 heart sound, the control circuit configured to use the auxiliary physiological signal in determining the patient status indicator, the auxiliary physiological signal including a motion-related acceleration.

2. The device of claim 1, wherein the patient status indicator indicates contractility of the heart.

3. The device of claim 1, wherein the device is configured to determine an auxiliary indicator using a characteristic of the auxiliary physiological signal, and wherein the control circuit is configured to:

use the auxiliary indicator in determining the patient status indicator; and

provide the patient status indicator for a user or automated process.

4. The device of claim 1, wherein the device is configured to detect respiration, the control circuit being configured to ignore, for purposes of determining the patient status indicator, an acceleration correlative to a S1 heart sound during a period of inhalation.

5. The device of claim 1, wherein the transducer is implantable.

6. The device of claim 1, wherein the control circuit is included with an external system, the control circuit being communicatively coupled with the transducer.

7. The device of claim 1, further comprising a therapy delivery circuit coupled to the control circuit, the therapy delivery circuit configured to deliver therapy to the heart in the form of electrical impulses.

8. The device of claim 7, wherein the control circuit is configured to adjust, using the patient status indicator, the therapy delivered by the therapy delivery circuit.

9. The device of claim 7, wherein the device is configured to mate to a lead system configured to deliver electrical impulses to the heart.

10. The device of claim 1, wherein the transducer comprises an accelerometer.

11. The device of claim 1, wherein the control circuit is configured to determine a peak-to-peak difference between a maximum amplitude of the acceleration correlative to the S1 heart sound and a minimum amplitude of the acceleration correlative to the S1 heart sound by:

identifying a time, t_m, associated with a beginning of the acceleration correlative to the S1 heart sound, and a time, t_n, associated with an ending of the acceleration correlative to the S1 heart sound;

identifying, during a span of time between t_m and t_n, a global maximum amplitude of the acceleration correlative to the S1 heart sound and a global minimum amplitude of the acceleration correlative to the S1 heart sound;

determining, for a plurality of accelerations correlative to respective S1 heart sounds, a central tendency of the global maximum amplitudes correlative to the respective S1 heart sounds and a central tendency of the global minimum amplitudes correlative to the respective S1 heart sounds; and

subtracting the central tendency of the global minimum amplitudes correlative to the respective S1 heart sounds from the central tendency of the global maximum amplitudes correlative to the respective S1 heart sounds to determine the peak-to-peak difference.

12. A method comprising:

using a transducer to detect an acceleration correlative to an S1 heart sound;

converting the acceleration correlative to S1 heart sound into an electrical signal using the transducer;

determining a patient status indicator using information about the acceleration correlative to the S1 heart sound, wherein the patient status indicator indicates at least one of contractility or a maximum time rate of change of pressure within a ventricle of a heart during a cardiac cycle; and

detecting an auxiliary physiological signal in conjunction with detection of the acceleration correlative to the S1 heart sound, the auxiliary physiological signal being used in determining the patient status indicator, wherein the auxiliary physiological signal includes a motion-related acceleration.

13. The method of claim 12, wherein the patient status indicator indicates contractility of the heart.

14. The method of claim 12, comprising:

determining an auxiliary indicator using a characteristic of the auxiliary physiological signal;

using the auxiliary indicator in determining the patient status indicator; and

providing the patient status indicator for a user or automated process.

15. The method of claim 12, comprising detecting respiration and ignoring, for purposes of determining the patient status indicator, an acceleration correlative to a S1 heart sound during a period of inhalation.

16. The method of claim 12, comprising storing a maximum amplitude of the acceleration correlative to the S1 heart sound and a minimum amplitude of the acceleration correlative to the S1 heart sound in a datastore, so that a trend regarding the maximum amplitude and the minimum amplitude may be obtained.

17. The method of claim 12, comprising adjusting, using the patient status indicator, a therapy delivered to the heart.

18. The method of claim 17, wherein the therapy comprises cardiac resynchronization therapy.

19. The method of claim 12, comprising determining a peak-to-peak difference between a maximum amplitude of the acceleration correlative to the S1 heart sound and a minimum amplitude of the acceleration correlative to the S1 heart sound by:

identifying a time, t_m, associated with a beginning of the acceleration correlative to the S1 heart sound, and a time, t_n, associated with an ending of the acceleration correlative to the S1 heart sound;

identifying, during a span of time between t_m and t_n, a global maximum amplitude of the acceleration correlative to the S1 heart sound and a global minimum amplitude of the acceleration correlative to the S1 heart sound;

determining, for a plurality of accelerations correlative to respective S1 heart sounds, a central tendency of the global maximum amplitudes correlative to the respective S1 heart sounds and a central tendency of the global minimum amplitudes correlative to the respective S1 heart sounds; and

subtracting the central tendency of the global minimum amplitudes correlative to the respective S1 heart sounds from the central tendency of the global maximum amplitudes correlative to the respective S1 heart sounds to determine the peak-to-peak difference.

20. A device comprising:

a transducer configured to convert an acceleration correlative to a S1 heart sound into an electrical signal; and

a control circuit coupled to the transducer, the control circuit configured to;

receive the electrical signal;

identify the acceleration correlative to the S1 heart sound;

determine a maximum amplitude of the acceleration correlative to the S1 heart sound and a minimum amplitude of the acceleration correlative to the S1 heart sound; and

determine a patient status indicator using an indication of a peak-to-peak difference between the maximum amplitude of the acceleration correlative to the S1 heart sound and the minimum amplitude of the acceleration correlative to the S1 heart sound;

wherein the patient status indicator indicates at least on of contractility or a maximum time rate of change of pressure within a ventricle of a heart during a cardiac cycle; and

wherein the device is configured to alter an electrode site selection parameter based on the contractility or the maximum time rate of change of pressure within the ventricle of the heart during the cardiac cycle.