Method and apparatus for quantitative assessment of neuromotor disorders

• US 8,845,554 B2
• Filed: 03/07/2008
• Issued: 09/30/2014
• Est. Priority Date: 03/09/2007
• Status: Active Grant

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Sarrafzadeh, Majid, Jafari, Roozbeh, Edgerton, Victor R., Jindrich, Devin L., Dabiri, Foad
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): DANEGA, RENEE A
• Application Number:
  US12/528,777
• Publication Number:
  US 20100113979A1
• Time in Patent Office: 2,398 Days
• Field of Search: 600/300, 600/301, 600/304, 600/546, 600/547, 600/551, 600/552, 600/553, 600/561, 600587-595
• US Class Current: 600/587
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/1107 Measuring contraction of parts of the body, e.g. organ, muscle apparatus for measuring work or force in general G01L
• CPC Class Codes: A61B 5/225 of the fingers, e.g. by monitoring hand-grip force
• CPC Class Codes: A61B 5/6825 Hand

Abstract

The present invention relates to methods and apparatus for quantitative assessment of neuromotor disorders using sensors and analyzing the data collected from the sensors to determine if a patient suffers any neuromotor disorders. In one embodiment, the present invention is a system for assessing neuromotor disorders in a body including a plurality of pressure sensors adapted for attachment to the body and measuring pressure, a med node connected to the plurality of pressure sensors for generating data corresponding to the plurality of pressure sensors, and an analysis unit connected to the med node for analyzing the data generated by the med node to determine the existence of a neuromotor disorder in the body.

Claims

1. A system for assessing neuromotor disorders in a body, comprising:

a hand-held device containing a plurality of pressure sensors for measuring pressure applied by the individual fingers of a hand of a person holding the device;

a med node connected to the plurality of pressure sensors for generating data corresponding to signals generated by the pressure sensors;

a screen display of a target force pattern for observation by the person holding the device for the purpose of the person holding the device tracking the displayed target force pattern with the individual fingers of the hand holding the device, while the target force pattern is being displayed; and

an analysis unit connected to the med node for analyzing the data generated by the med node to determine the existence of a neuromotor disorder in the body;

wherein the analysis unit is configured to analyze the data generated by the med node using time-domain cross-correlation to measure the similarity between the force pattern generated by the individual fingers of the hand and the target force pattern.

2. The system of claim 1 wherein the analysis unit is configured to analyze the data generated by the med node using frequency matching to determine the degree to which the frequency of force generated by the individual fingers matches the frequency of force of the target force pattern.

3. The system of claim 1 wherein the analysis unit is configured to analyze the data generated by the med node using variance calculations to calculate the difference between the target force pattern and the force pattern generated by the fingers.

4. The system of claim 1 wherein the analysis unit is configured to analyze the data generated by the med node using force sharing calculations to calculate the variance between applied force over time by an individual finger, or all the fingers, and the target force pattern.

5. The system of claim 1 wherein the analysis unit is sized to be held by one hand of the person.

10. The system of claim 1 wherein the target force pattern being displayed for observation by the person holding the device is a predetermined pattern, a random pattern, or an adaptive pattern based on the person'"'"'s ability to track the observed pattern.

6. A method for determining abnormal pressure patterns applied by fingers on a hand of a person holding a sensor device containing sensors for each of the fingers, the method comprising:

receiving signals corresponding to a force pattern applied by the fingers to the sensor; and

analyzing the signals produced by the sensors, to determine the existence of a neuromotor disorder;

wherein analyzing the signals from the sensors includes using time-domain cross-correlation to measure the similarity between the force pattern generated by the individual fingers and the target force pattern.

7. The method of claim 6 wherein analyzing the signals from the sensor device includes using frequency matching to determine the degree to which the frequency of force generated by the individual fingers matches the frequency of force of the target force pattern.

8. The method of claim 6 wherein analyzing the signals from the sensor device includes using variance calculations to calculate the difference between the target force pattern and the force pattern generated by the fingers.

9. The method of claim 6 wherein analyzing the signals from the sensor device includes using force sharing calculations to calculate the variance between applied force over time by an individual finger, or all the fingers, and the target force pattern.

11. The method of claim 6 further comprising calibrating the sensor device by applying the maximum pressure exertable by the person on the device.

12. A method, comprising:

presenting on a display screen a pattern of a target force representing a target sequence of force to be applied to a plurality of pressure sensors of a handgrip;

receiving data from the plurality of pressure sensors indicating at least one actual sequence of force applied to the plurality of pressure sensors in response to the presenting the pattern of the target force on the display screen; and

cross-correlating the target sequence and the actual sequence in the time domain, thereby identifying a time lag between the sequences.

13. The method of claim 12, wherein the time lag indicates an ability to follow the pattern of the target force.

14. The method of claim 12, further comprising cross-correlating two actual sequences in the time domain, thereby identifying a time lag between the sequences, wherein a first of the two actual sequences is a sequence of data from a first one of the plurality of pressure sensors, and a second of the two actual sequences is a sequence of data from a second one of the plurality of pressure sensors, wherein the time lag indicates an ability to coordinate motion of two fingers placed on the handgrip.