Optical cochlear stimulation devices and methods

• US 8,845,705 B2
• Filed: 06/24/2010
• Issued: 09/30/2014
• Est. Priority Date: 06/24/2009
• Status: Active Grant

• Current Assignee: EarLens Corporation
• Original Assignee: EarLens Corporation
• Inventors: Perkins, Rodney C., Puria, Sunil
• Primary Examiner(s): PINKNEY, DAWAYNE
• Application Number:
  US12/822,810
• Publication Number:
  US 20110152976A1
• Time in Patent Office: 1,559 Days
• Field of Search: 607 88- 94, 600/25
• US Class Current: 607/89
• CPC Class Codes: A61N 1/36038 Cochlear stimulation
• CPC Class Codes: A61N 2005/063 comprising light transmitting means, e.g. optical fibres
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/0622 Optical stimulation for exciting neural tissue
• CPC Class Codes: H04R 2225/0216 BTE hearing aids having a receiver in the ear mould
• CPC Class Codes: H04R 2225/67 Implantable hearing aids or parts thereof not covered by H04R25/606
• CPC Class Codes: H04R 23/008 using optical signals for detecting or generating sound
• CPC Class Codes: H04R 25/606 acting directly on the eardrum, the ossicles or the skull, e.g. mastoid, tooth, maxillary or mandibular bone, or mechanically stimulating the cochlea, e.g. at the oval window

Abstract

An output assembly is sized for placement in the middle and inner ear, such that removal of bone can be decreased. The output assembly may comprise at least one photo detector, a demultiplexer and an optical array sized to pass through an incision in the eardrum. An input transducer assembly is configured to transmit a multiplexed optical signal to the output assembly. The input assembly can be configured to transmit the multiplexed optical signal through the eardrum, such that tissue removal can be decreased and the device can be placed without removal of bone, for example. The multiplexed optical signal may comprise a pulse width modulated signal so as to decrease the effect of non-linearities of the light source and light detector and provide quality sound to the user.

Claims

1. A method of stimulating tissue, the method comprising:

transmitting multiplexed light energy to the tissue to stimulate the tissue with the multiplexed light energy, wherein the multiplexed light energy is transmitted through an eardrum, and

wherein the eardrum acts as a transmission medium for the transmitted multiplexed light energy.

2. A method of transmitting a sound to a user having an eardrum, the user having a cochlea comprising a tissue, the method comprising:

transmitting a multiplexed optical signal to the tissue of the cochlea such that the user hears the sound in response to the multiplexed optical signal and wherein the multiplexed optical signal is transmitted through the eardrum, and

wherein the eardrum acts as a transmission medium for the transmitted multiplexed optical signal.

3. The method of claim 2 wherein the multiplexed optical signal is transmitted to an optical structure supported with the middle ear, the optical structure configured to separate wavelengths of the multiplexed signal to stimulate the cochlea.

4. The method of claim 3 wherein the optical structure is affixed to the middle ear.

5. The method of claim 3 wherein the optical structure is sized to pass through an incision in the eardrum for placement in the middle ear.

6. The method of claim 3 wherein the optical structure comprises at least one of an optical filter, an optical fiber, a grating, an etalon, a plurality of optical fibers, a waveguide, a plurality of waveguides, a mirror or a prism.

7. The method of claim 3 wherein the multiplexed optical signal comprises a plurality of channels, each channel of the plurality corresponding to at least one frequency of the sound.

8. The method of claim 7 wherein the plurality of channels corresponds to at least about sixteen channels and said at least one frequency corresponds to at least about sixteen frequencies.

9. The method of claim 7 wherein the multiplexed optical signal is transmitted through the eardrum with a plurality of light sources, each light source configured to transmit a light signal corresponding to said channel of the plurality such that said light source corresponds to said at least one frequency of sound.

10. The method of claim 9 wherein the plurality of light sources comprises at least three light sources and wherein each of the at least three light sources is configured to emit separate wavelengths of light.

11. The method of claim 2 wherein the multiplexed optical signal is transmitted through the eardrum of the user to at least one optical waveguide, the at least one optical waveguide affixed to the middle ear and coupled to an optical array positioned at least partially within the cochlea.

12. The method of claim 11 wherein the at least one waveguide comprises at least one optical fiber and the optical array comprises an array of openings configured to emit light from the at least one optical fiber.

13. The method of claim 11 wherein the at least one waveguide and optical array are sized to pass through an incision in the eardrum.

14. The method of claim 11 wherein the multiplexed optical signal comprises a wavelength multiplexed optical signal, the wavelength multiplexed optical signal comprising a plurality of wavelengths such that each wavelength corresponds to an opening of the array.

15. The method of claim 14 wherein each wavelength of the plurality corresponds to an opening of the array.

16. The method of claim 14 wherein the at least one waveguide comprises a plurality of waveguides, each waveguide of the plurality coupled to a corresponding opening of the array and a corresponding wavelength of the plurality of wavelengths such that tissue stimulating light is passed through the opening in response to the wavelength.

17. The method of claim 16 further comprising positioning an optical structure in the middle ear of the user to separate the wavelengths to correspond with each waveguide, and such that each separated wavelength corresponding to each waveguide is transmitted to said each waveguide based on the wavelength.

18. The method of claim 16 further comprising a plurality of optical filters positioned in the middle ear of the user and wherein the wavelengths are separated with the optical filters, each optical filter positioned over one waveguide and configured to pass the wavelengths corresponding to the opening coupled to said one waveguide.

19. The method of claim 16 further comprising a grating configured to select the wavelengths of each waveguide to correspond to each opening.

20. The method of claim 11 wherein the multiplexed optical signal comprise a time division multiplexed signal.

21. The method of claim 20 wherein the time division multiplexed signal comprises a plurality of time-slots, each time slot of the plurality corresponding to an opening of the array.

22. The method of claim 21 wherein the time division multiplexed signal comprises a plurality of time slots and a clock signal and wherein circuitry is coupled to the at least one waveguide and the optical array to receive the clock signal and divide the time division multiplexed signal among the openings of the array such that each time slot corresponds to an opening of the array.

23. The method of claim 22 wherein each time slot corresponds to at least one frequency of the sound such that light is passed through each opening in response to a portion of the multiplexed signal corresponding to the time slot.

24. The method of claim 23 the time division multiplexed signal is pulse width modulated such that each timeslot of the plurality comprises a pulse of light having a duration that corresponds to light through the opening corresponding to said timeslot.

25. The method of claim 20 further comprising a light source positioned in the middle ear and coupled to the optical array positioned at least partially within the cochlea and wherein the light sources emits light in response to the time division multiplexed optical signal.

26. The method of claim 25 further comprising modulator coupled to the light source and wherein the modulator adjusts the light beam to emit light from an opening of the at least one optical fiber in response to the time division multiplexed optical signal.

27. The method of claim 26 wherein the at least one optical waveguide comprises a plurality of wavelength selective optical waveguides and wherein the modulator adjusts a wavelength of the light to direct the light substantially along each of the wavelength selective optical waveguides to an opening on a distal end of said waveguide.

28. The method of claim 26 wherein the light source comprises a laser and the opening comprises a plurality of openings disposed along the at least one waveguide and wherein the modulator is configured to adjust a mode structure of the laser to transmit light selectively through each of the plurality of openings.

29. The method of claim 28 wherein the mode structure comprises a first mode structure and a second mode structure and the plurality of openings comprises a first opening and a second opening and wherein the at least one waveguide is configured to emit light substantially through the first opening in response to the first mode structure and through the second opening in response to the second mode structure.

30. The method of claim 2 wherein the multiplexed optical signal is transmitted to at least one optical fiber extending into the cochlea.

31. The method of claim 30 wherein the at least one optical fiber is sized to pass through an incision in the middle ear.

32. The method of claim 30 wherein the at least one optical fiber comprises a plurality of optical fibers extending into the cochlea, each fiber corresponding to at least one frequency of the sound.

33. The method of claim 30 wherein each fiber is configured to stimulate the cochlea at a predetermined location of the cochlea corresponding to a corresponding range of frequencies in response to the at least one frequency of the sound.

34. The method of claim 2 wherein the multiplexed optical signal is transmitted through at least one of an opening or a window in the eardrum.

35. The method of claim 2 wherein the optical array, the at least one waveguide, and the demultiplexer comprise substantially non-magnetic materials configured for MRI imaging when implanted in the user.

36. A system to stimulate tissue of a user having an eardrum and a middle ear, the system comprising:

a plurality of openings configured for placement at least partially within the tissue;

circuitry configured to receive a signal from a source;

a least one light source coupled to the circuitry and configured to emit a multiplexed optical signal comprising a plurality of light pulses; and

at least one waveguide configured to receive the multiplexed optical signal and pass light through the openings in response to the light pulses to stimulate the tissue;

wherein the multiplexed optical signal is transmitted through the eardrum of the user to the at least one waveguide, the at least one waveguide affixed to the middle ear to receive the multiplexed optical signal transmitted through the eardrum, wherein the eardrum acts as a transmission medium for the multiplexed optical signal.

37. A system to transmit an audio signal to a user having an eardrum and a middle ear, the system comprising:

an optical array comprising a plurality of openings configured for placement at least partially within a cochlea of the user;

circuitry configured to receive the audio signal from a sound source;

at least one light source coupled to the circuitry and configured to emit a multiplexed optical signal comprising a plurality of light pulses; and

at least one waveguide configured to receive the multiplexed optical signal and pass light through the openings in response to the light pulses;

wherein the multiplexed optical signal is transmitted through the eardrum of the user to the at least one waveguide, the at least one waveguide affixed to the middle ear and coupled to the optical array positioned at least partially within the cochlea, and

wherein the eardrum acts as a transmission medium for the multiplexed optical signal.

38. The system of claim 37 the circuitry is configured to determine widths of a plurality of light pulses and wherein each light pulse corresponds to an opening of the array and a width of said each light pulse corresponds to an amount of light through said corresponding opening of the array.

39. The system of claim 37 wherein the circuitry is configured to determine frequencies of the audio signal and wherein the frequencies correspond to openings of the array and wherein the circuitry is configured to determine a width of each pulse in response to one or more of the frequencies.

40. The system of claim 37 wherein the at least one light source comprises a plurality of light sources and wherein each light source corresponds to one opening of the array.

41. The system of claim 40 each of the plurality of light sources is configured to emit light comprising wavelengths substantially separated from wavelengths of other light sources of the plurality.

42. The system of claim 40 wherein the plurality of light sources comprises at least three light sources and the optical array comprises at least three openings and wherein each of the at least three light sources corresponds to one opening of the at least three openings of the array.

43. The system of claim 42 each of the at least three light sources is configured to emit light comprising wavelengths substantially separated from others of the at least three light sources and wherein the wavelengths of each source correspond to one opening of the at least three openings.

44. The system of claim 37 wherein the at least one waveguide comprises a plurality of waveguides and wherein each waveguide of the plurality corresponds to one opening of the array.

45. The system of claim 44 wherein the plurality of light waveguides comprises at least three light waveguides and the optical array comprises at least three openings and wherein each of the at least three light waveguides corresponds to one opening of the at least three openings of the array.

46. The system of claim 37 further comprising an optical structure configured to receive the multiplexed optical signal, the optical structure configured for placement in the middle, the optical structure configured to select wavelengths of the multiplexed signal.

47. The system of claim 46 wherein the optical structure is sized to pass through an incision in the eardrum for placement in the middle ear and wherein the optical array is sized for placement at least partially inside the cochlea through a round window of the cochlea.

48. The system of claim 46 wherein the optical structure comprises at least one of an optical filter, a grating, an etalon, a plurality of optical fibers, or a prism.

49. The system of claim 46 wherein the multiplexed optical signal comprises a plurality of optical channels, each optical channel of the plurality corresponding to at least one frequency of the sound.

50. The system of claim 49 wherein the plurality of optical channels corresponds to at least about sixteen channels and said at least one frequency corresponds to at least about sixteen frequencies.

51. The system of claim 49 further comprising an elongate optical transmission structure configured for placement at least partially within the ear canal of the user and wherein the elongate optical transmission structure is configured to transmit multiplexed optical signal through the eardrum.

52. The system of claim 37 wherein the at least one waveguide and the optical array are sized to pass through an incision in the eardrum.

53. The system of claim 37 wherein the multiplexed optical signal comprises a wavelength multiplexed optical signal, the wavelength multiplexed optical signal comprising a plurality of wavelengths such that each wavelength corresponds to an opening of the array.

54. The system of claim 53 wherein each wavelength of the plurality corresponds to an opening of the array.

55. The system of claim 53 wherein the plurality of wavelengths comprises at least three wavelengths and wherein the plurality of openings comprises at least three openings and wherein each wavelength of the plurality corresponds to one opening of the at least three openings.

56. The system of claim 37 wherein the circuitry is configured to transmit a series of the light pulses to correspond to openings of the array.

57. The system of claim 56 wherein the series comprises a plurality of pulses and wherein each pulse of the plurality corresponds to one opening of the plurality of openings.

58. The system of claim 57 wherein the plurality of openings comprises at least three openings and wherein the series comprises at least three pulses and wherein each pulse of the at least three pulses corresponds to one opening of the at least three openings.

59. The system of claim 56 wherein the series comprises a timing pulse.

60. The system of claim 59 wherein the timing pulse comprises a substantially fixed width and wherein the timing pulse comprises energy to power circuitry coupled to the plurality of openings.

61. The system of claim 59 further comprising switching circuitry coupled to the at least one waveguide to couple sequentially each opening of the plurality to the at least one waveguide in response to the timing pulse such that each pulse of the series corresponds to one opening of the plurality.

62. The system of claim 61 wherein the series of pulses comprises a pre-determined order and timing of the pulses and wherein the switching circuitry comprises a timer coupled to switches to open the switches and close the to correspond with pulses of the series.

63. The system of claim 61 wherein the series comprises at least three pulses and wherein the switching circuitry is configured to coupled at least one waveguide sequentially to each opening of the at least three such that each pulse of the series corresponds to one opening of the plurality.

64. The system of claim 56 further comprising a light source positioned in the middle ear and coupled to the optical array positioned at least partially within the cochlea and wherein the light source emits light in response to the time division multiplexed optical signal.

65. The system of claim 64 further comprising modulator coupled to the light source and wherein the modulator adjusts the light beam to emit light from an opening of the at least one optical fiber in response to the time division multiplexed optical signal.

66. The system of claim 65 wherein the at least one optical waveguide comprises a plurality of wavelength selective optical waveguides and wherein the modulator adjusts a wavelength of the light to direct the light substantially along one of the wavelength selective optical waveguides to an opening on a distal end of the waveguide.

67. The system of claim 65 wherein the light source comprises a laser and the opening comprises a plurality of openings disposed along the at least one waveguide and wherein the modulator is configured to adjust a mode structure of the laser to transmit light substantially through one of the plurality of openings.

68. The system of claim 37 wherein the optical array, the at least one waveguide, and the demultiplexer comprise substantially non-magnetic materials configured for MRI imaging when implanted in the user.

69. A method of providing a hearing prosthesis for a user, the method comprising:

making an incision in an eardrum of the user, the eardrum comprising an annulus; and

passing an optical array, at least one waveguide, and a demultiplexer through the incision;

wherein the demultiplexer is placed to receive multiplexed light energy transmitted through the eardrum, and

wherein the eardrum acts as a transmission medium for the multiplexed optical signal.

70. The method of claim 69 wherein the incision extends at least partially through the annulus.

71. The method of claim 69 wherein the eardrum is positioned to a side of an ear canal to pass the optical array, the demultiplexer and the at least one waveguide through the incision.

72. The method of claim 69 wherein the at least one waveguide and the demultiplexer are affixed to the middle ear of the user.

73. The method of claim 69 wherein the optical array is positioned at least partially through a round window and wherein the at least one waveguide and the demultiplexer are positioned in a middle ear of the user.

74. The method of claim 73 wherein the at least one waveguide and the demultiplexer are affixed to the middle ear of the user.

75. The method of claim 69 wherein the at least one waveguide comprises at least three waveguides.

76. The method of claim 75 wherein the demultiplexer comprises an optical demultiplexer.

77. The method of claim 76 wherein the optical demultiplexer comprises at least three filters to separate at least three wavelengths of light.

78. The method of claim 69 wherein the demultiplexer comprises switching circuitry and a timer.

79. The method of claim 69 wherein the optical array, the at least one photodetector, and the demultiplexer passed through the incision comprise substantially non-magnetic materials configured for MRI imaging.

80. A device to stimulate tissue of a user having an eardrum, the device comprising:

means for generating a multiplexed optical signal;

means for transmitting the multiplexed optical signal through the eardrum, wherein the eardrum acts as a transmission medium for the transmitted multiplexed optical signal, and

means for stimulating tissue in response to the optical signal.