Method for measuring analysis object and measuring device

• US 8,845,966 B2
• Filed: 12/07/2012
• Issued: 09/30/2014
• Est. Priority Date: 06/16/2008
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: Panasonic Corporation (Panasonic Holdings Corporation)
• Inventors: Fujii, Takaaki, Takahara, Yoshifumi, Terashima, Noriyoshi
• Primary Examiner(s): Sines, Brian J
• Application Number:
  US13/707,971
• Publication Number:
  US 20130140178A1
• Time in Patent Office: 662 Days
• Field of Search: 422/50, 422/68.1, 422/82.01, 422/82.02
• US Class Current: 422/68.1
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 27/327 Biochemical electrodes , e.g. electrical or mechanical details for in vitro measurements
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 33/5438 Electrodes
• CPC Class Codes: Y10T 436/11 Automated chemical analysis

Abstract

The measurement device comprises a sensor holder to which is removable to a biosensor. The sensor holder has measurement-use connection terminals that are in contact with the electrode system in the biosensor and are used to take off signals required for measuring the specific component, and thermocouple-use connection terminals that are in contact with the thermocouple in the biosensor and are used to take off the thermoelectromotive force signals.

Claims

1. A measurement device, comprising:

a sensor holder;

a biosensor, the biosensor being removable connected to the sensor holder;

a cavity in the biosensor for holding an analysis object;

an electrode system in the biosensor for measuring the analysis object; and

a thermocouple or a part thereof formed by joining at least two substances and that outputs a temperature difference as a thermoelectromotive force,

wherein the sensor holder has measurement-use connection terminals that are in contact with the electrode system in the biosensor and are used for communicating signals required for measuring the specific component, and thermocouple-use connection terminals that are in contact with the thermocouple in the biosensor and are used for communicating the thermoelectromotive force signals.

2. The measurement device according to claim 1,

wherein the thermocouple-use connection terminal is made of the same material as the thermocouple in the biosensor with which it is in contact, or is made of an a compensating lead wire corresponding to the material of the thermocouple.

3. The measurement device according to claim 1,

wherein the thermocouple-use connection terminals are both made of the same material, which is different from the materials constituting the thermocouple.

4. The measurement device according to claim 1,

wherein the surface of the thermocouple-use connection terminals has undergone metal plating.

5. The measurement device according to claim 1, wherein

the thermocouple provided to the biosensor, and a second thermocouple form a biosensor/measurement device integrated thermocouple via the thermocouple-use connection terminals.

6. The measurement device according to claim 5,

wherein the ends of the second thermocouple disposed in the measurement device are disposed as close as possible.

7. The measurement device according to claim 6,

wherein the ends of the second thermocouple are a reference temperature junction of the thermocouple, which is integrated with the biosensor,

and comprise an environmental temperature sensor to acquire the reference temperature/environmental temperature disposed on or near the reference temperature junction of the integrated thermocouple.

8. The measurement device according to claim 7,

wherein the environmental temperature sensor individually has a first temperature sensor for acquiring the reference temperature of the integrated thermocouple, and a second temperature sensor for acquiring the environmental temperature of the measurement device.

9. The measurement device according to claim 1, wherein the thermocouple, which is provided on the biosensor, is configured to measure integrally the temperature of the measuring junction.

10. The measurement device according to claim 9,

wherein the thermocouple-use connection terminals are such that the ends of the thermocouple on the biosensor are disposed as close as possible.

11. The measurement device according to claim 10,

further comprising a reference temperature junction temperature sensor that is disposed in contact with the ends of the reference temperature junction of the thermocouple disposed in the biosensor, or nearby these ends, and is for acquiring the reference temperature/environmental temperature of the thermocouple.

12. The measurement device according to claim 11,

wherein the reference temperature junction temperature sensor individually has a third temperature sensor for acquiring the reference temperature of the thermocouple disposed in the biosensor, and a fourth temperature sensor for acquiring the environmental temperature of the measurement device.

13. The measurement device according to claim 8, wherein

the biosensor comprises:

the cavity for holding an analysis object;

the electrode system for measuring the analysis object; and

the thermocouple formed by joining the at least two dissimilar substances.

14. The measurement device according to claim 1,

further comprising an arithmetic processing unit for calculating temperature information at the measuring junction, which is one of the junctions of the thermocouple formed in the biosensor, using as a reference the reference temperature/environmental temperature or the reference temperature.

15. The measurement device according to claim 14,

wherein the arithmetic processing unit corrects the measured value that is the result of measuring the specific component in the drop of analysis object placed in the cavity, on the basis of the reference temperature/environmental temperature or the reference temperature.

16. The measurement device according to claim 14,

wherein the arithmetic processing unit corrects the measured value that is the result of measuring the specific component in the drop of analysis object placed in the cavity, on the basis of the temperature information at the measuring junction.

17. The measurement device according to claim 15,

wherein the arithmetic processing unit corrects the various correction items with respect to the result of measuring in the drop of analysis object placed in the cavity, on the basis of the reference temperature/environmental temperature or the reference temperature, and/or the temperature information at the measuring junction, and corrects the measured value on the basis of these temperature-corrected correction items.

18. The measurement device according to claim 14,

further comprising a current/voltage conversion circuit for converting the current values measured by the electrode system and the environmental temperature sensor or the reference temperature junction sensor into voltage;

an amplifier circuit for amplifying the thermoelectromotive force;

an A/D converter circuit for converting the voltage converted by the current/voltage conversion circuit or the amplifier circuit into a digital signal; and

a memory device for recording the various measured values and the various temperature information converted into a digital signal by the A/D converter circuit,

wherein the arithmetic processing unit computes the various measured values and the various temperature information from the digital signals, and corrects the various measured values using the various temperature information according to various conditions.

19. The measurement device according to claim 18,

wherein the memory device has a correction table used by the arithmetic processing unit for correcting the various correction items or the measured values corresponding to the environmental temperature or the reference temperature and the measuring junction temperature.