Use of protoberberines as an active substance regulating the pilosebaceous unit

• US 8,846,019 B2
• Filed: 09/06/2006
• Issued: 09/30/2014
• Est. Priority Date: 09/06/2005
• Status: Active Grant

• Current Assignee: Sederma, Co.
• Original Assignee: Sederma, Co.
• Inventors: Lintner, Karl, Mas Chamberlin, Claire
• Primary Examiner(s): Fubara, Blessing M
• Assistant Examiner(s): Berrios, Jennifer A
• Application Number:
  US11/991,587
• Publication Number:
  US 20090269395A1
• Time in Patent Office: 2,946 Days
• Field of Search: None
• US Class Current: 424/73
• CPC Class Codes: A61K 8/361 Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/08 Antiseborrheics
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: A61Q 7/02 Preparations for inhibiting or slowing hair growth

Abstract

The present invention relates to cosmetic use, by topic application on the skin of at least one protoberberine, with exception of berberine, or a vegetable extract containing it, as an active substance reducing activity of the pilosebaceous unit, preferably inhibiting activity of the pilosebaceous unit. In particular, the invention relates to cosmetic use of at least one protoberberine, with exception of berberine, or a vegetable extract containing it, as an agent reducing, preferably inhibiting the growth of hairs of the face and/or the body, and/or seborrheic activity of the sebaceous glands. The invention also relates to a cosmetic composition comprising in a dermatologically acceptable carrier, at least one protoberberine, with exception of berberine, or a vegetable extract containing protoberberines, as an active substance, which reduces, preferably inhibits the skin'"'"'s pilosebaceous unit activity.

Claims

1. A method of treatment to reduce the frequency of shaving and/or depilation of a subject in need thereof comprising applying to skin of face and/or body of the subject a composition comprising an effective amount of palmatine, and a dermatologically acceptable carrier.

2. The method of claim 1, wherein said palmatine is obtained by chemical synthesis or vegetable extraction.

3. The method of claim 1, wherein said palmatine is provided as a vegetable extract selected from the group consisting of an extract of Fibraurea recisa and an extract of Chelidonium majus.

4. The method of claim 1, wherein said palmatine is present in an amount from about 0.00001% to about 10% w/w with respect to total weight of the composition.

5. The method of claim 4, wherein said palmatine is present in an amount from about 0.0001% to about 1% w/w with respect to total weight of the composition.

6. The method of claim 3, wherein said vegetable extract is present in an amount from about 0.0001% to about 20% w/w with respect to total weight of the composition.

7. The method of claim 6, wherein said vegetable extract is present in an amount from about 0.001% to about 5% w/w with respect to total weight of the composition.

8. The method of claim 1, wherein said composition further comprises microspheres.

9. The method of claim 1, wherein said dermatologically acceptable carrier is selected from the group consisting of an aqueous or hydroalcoholic solution, a water in oil emulsion, an oil in water emulsion, a microemulsion, an aqueous gel, an anhydrous gel, a serum or a vesicle dispersion.

10. The method of claim 1, wherein said palmatine is in the form of a solution, dispersion, emulsion, paste, or powder, individually or as a premix, or in vehicles such as macrocapsules, microcapsules, or nanocapsules, macrospheres, microspheres or nanospheres, liposomes, oleosomes or chylomicrons, macroparticles, microparticles, or nanoparticles or macrosponges, microsponges or nanosponges, or adsorbed on organic polymer powders, talcs, bentonites, or other inorganic or organic supports.

11. The method of claim 1, wherein said composition is formulated in the form of creams, lotions, ointments, milks, gels, emulsions, dispersions, solutions, suspensions, cleansers, foundations, anhydrous preparations, sticks, lipsticks, body and bath oils, shower gels, bath gels, shampoos, scalp treatment lotions, cream or lotion for care of skin or hair, sun-screen lotions, milks or creams, artificial suntan lotions, creams or milks, shaving creams or foams, aftershave lotions, make-up, mascaras or nail varnishes, skin “

essences,”

serums, adhesive or absorbent materials, transdermal patches, powders, emollient lotion, emollient milk, emollient cream, sprays, foundation tint bases, pomade, emulsion, colloid, compact or solid suspension, pencil, sprayable formulation, or brush on formulation.