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Methods of improving stem cell homing and engraftment

  • US 8,846,393 B2
  • Filed: 11/29/2006
  • Issued: 09/30/2014
  • Est. Priority Date: 11/29/2005
  • Status: Active Grant
First Claim
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1. A method of enhancing cell homing and engraftment potential, the method comprising ex-vivo or in vitro culturing a population of isolated CD34+ hematopoietic stem cells in the presence of 1 to 10 mM nicotinamide for a period of time of 5-30 hours, wherein said period of time is insufficient for proliferation of said isolated CD34+ hematopoietic stem cells, and wherein said culturing results in down-regulation of CD26 expression as compared to isolated CD34+ hematopoietic stem cells cultured in the absence of nicotinamide.

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