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Treatment of neurological deficits in the striatum or substanta nigra pars compacta

  • US 8,846,394 B2
  • Filed: 11/11/2008
  • Issued: 09/30/2014
  • Est. Priority Date: 09/28/2004
  • Status: Active Grant
First Claim
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1. A method for differentiating cells isolated from mammalian umbilical cord tissue substantially free of blood towards a dopaminergic phenotype, comprising treating the cells isolated from mammalian umbilical cord tissue substantially free of blood with a composition comprising human recombinant GDF5, Sonic Hedgehog, retinoic acid and FGF8 in an amount sufficient to induce the cells isolated from mammalian umbilical cord tissue substantially free of blood to differentiate towards a dopaminergic phenotype.

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