Glucagon-like peptide-2 analogs
First Claim
Patent Images
1. An intestinotrophic GLP-2 analog of SEQ ID NO:
- 2, wherein at least one amino acid at one or more positions selected from the group consisting of positions 1, 5, 7, 16-18, 25, and 33 is substituted with an amino acid other than a wild type, mammalian GLP-2 residue;
wherein positions 2-4, 6, 8-15, 19-24, and 26-32 are unmodified, and wherein 4 to 8 residues are optionally deleted from the C-terminus of SEQ ID NO;
2.
0 Assignments
0 Petitions
Accused Products
Abstract
Analogs of glucagon-like peptide 2, a product of glucagon gene expression, have been identified as intestinal tissue growth factors. Their formulation as pharmaceutical, and therapeutic use in treating disorders of the small bowel, are described.
30 Citations
13 Claims
-
1. An intestinotrophic GLP-2 analog of SEQ ID NO:
- 2, wherein at least one amino acid at one or more positions selected from the group consisting of positions 1, 5, 7, 16-18, 25, and 33 is substituted with an amino acid other than a wild type, mammalian GLP-2 residue;
wherein positions 2-4, 6, 8-15, 19-24, and 26-32 are unmodified, and wherein 4 to 8 residues are optionally deleted from the C-terminus of SEQ ID NO;
2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- 2, wherein at least one amino acid at one or more positions selected from the group consisting of positions 1, 5, 7, 16-18, 25, and 33 is substituted with an amino acid other than a wild type, mammalian GLP-2 residue;
-
13. The peptide [desNH2Tyr1]hGLP-2(1-33).
Specification