Wireless recording and stimulation of brain activity
First Claim
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1. A medical device for recording and stimulating brain activity at a site of device implantation, comprising:
- an implantable flexible substrate having a dura-facing side and an opposing brain-facing side;
an array of electrodes disposed on said brain-facing side and adapted for sensing electrical signals from a subject'"'"'s brain;
a reference electrode mounted on said dura-facing side, wherein said reference electrode is physically separated from the subject'"'"'s brain by the flexible substrate and adapted to provide a reference voltage;
implantable control circuitry in communication with the brain-facing electrodes and said dura-facing reference electrode;
implantable wireless transmission circuitry connected to the control circuitry and adapted to transmit digital data derived from said sensed brain electrical signals to receiving circuitry external to the site of device implantation; and
implantable wireless receiver circuitry for receiving wireless commands transmitted from a site external to the site of device implantation, wherein said implantable control circuitry provides an electrical stimulus to the subject'"'"'s brain via at least two of said brain-facing electrodes and records sensed electrical signals based on said reference voltage and said sensed electrical signals.
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Abstract
Subdural arrays transmit electrocorticogram recordings wirelessly, across the patient'"'"'s skull, allowing the craniotomy used for surgical placement of the arrays to be completely closed. In various embodiments, the arrays also respond to commands, applying signal patterns to the patient'"'"'s brain for diagnostic and treatment purposes.
26 Citations
17 Claims
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1. A medical device for recording and stimulating brain activity at a site of device implantation, comprising:
- an implantable flexible substrate having a dura-facing side and an opposing brain-facing side;
an array of electrodes disposed on said brain-facing side and adapted for sensing electrical signals from a subject'"'"'s brain;
a reference electrode mounted on said dura-facing side, wherein said reference electrode is physically separated from the subject'"'"'s brain by the flexible substrate and adapted to provide a reference voltage;
implantable control circuitry in communication with the brain-facing electrodes and said dura-facing reference electrode;
implantable wireless transmission circuitry connected to the control circuitry and adapted to transmit digital data derived from said sensed brain electrical signals to receiving circuitry external to the site of device implantation; and
implantable wireless receiver circuitry for receiving wireless commands transmitted from a site external to the site of device implantation, wherein said implantable control circuitry provides an electrical stimulus to the subject'"'"'s brain via at least two of said brain-facing electrodes and records sensed electrical signals based on said reference voltage and said sensed electrical signals. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- an implantable flexible substrate having a dura-facing side and an opposing brain-facing side;
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16. A method of brain monitoring and treatment, the method comprising the steps of:
- subdurally implanting a device comprising a flexible substrate having a dura-facing side and an opposing brain-facing side, wherein the flexible substrate comprises an array of electrodes positioned on the brain-facing side for sensing signals generated by the subject'"'"'s brain or applying an electrical stimulus to the subject'"'"'s brain and a reference electrode positioned on the dura-facing side wherein said reference electrode is physically separated from the subject'"'"'s brain by the flexible substrate and is adapted to provide a reference voltage;
recording sensed electrical signals based on said reference voltage and said sensed electrical signals;
wirelessly transmitting digital data derived from the brain signals sensed by electrodes within said array of electrodes; and
transmitting wireless commands to cause a delivery of an electrical stimulus to the patient'"'"'s brain via at least two electrodes within said array of electrodes. - View Dependent Claims (17)
- subdurally implanting a device comprising a flexible substrate having a dura-facing side and an opposing brain-facing side, wherein the flexible substrate comprises an array of electrodes positioned on the brain-facing side for sensing signals generated by the subject'"'"'s brain or applying an electrical stimulus to the subject'"'"'s brain and a reference electrode positioned on the dura-facing side wherein said reference electrode is physically separated from the subject'"'"'s brain by the flexible substrate and is adapted to provide a reference voltage;
Specification