Implantable bio-electro-physiologic interface matrix
First Claim
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1. A device for implantation and detection at a target site, the device comprising:
- a biologic component comprising a cell layer having cells from the target site pre-positioned on or in the device prior to implantation, wherein said pre-positioned cells are adapted to respond to a physiological signal from a patient; and
an electronic component comprising at least one sensor and at least one electrode contacting said biologic component.
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Abstract
An implantable device (100) having an electronic component (110) and a biologic materials component (130). The biologic materials component has target cells in a matrix that interfaces the electronic component with the surrounding environment.
66 Citations
22 Claims
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1. A device for implantation and detection at a target site, the device comprising:
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a biologic component comprising a cell layer having cells from the target site pre-positioned on or in the device prior to implantation, wherein said pre-positioned cells are adapted to respond to a physiological signal from a patient; and an electronic component comprising at least one sensor and at least one electrode contacting said biologic component. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A defibrillation device for implantation at a target site, the device comprising:
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a cell layer having cells from the target site pre-positioned on or in the device prior to implantation, wherein said pre-positioned cells are adapted to respond to a physiological signal from the target site; at least one sensor for sensing the response to the physiological signal from said cell layer; and at least one defibrillation electrode contacting said cell layer for imparting defibrillation energy to the target site.
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14. A method for detecting a physiological signal at a target site by implanting a bio-electro-physiologic interface matrix device, the method comprising:
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providing a biologic component comprising a cell layer having cells from the target site pre-positioned on or in the bio-electro-physiologic interface matrix device prior to implantation, wherein said pre-positioned cells are adapted to respond to a physiological signal from a patient; growing the biologic component within an electronic component, wherein the electronic component comprises; at least one sensor; and at least one electrode; and implanting the device at the target site; wherein said cells comprising the cell layer are selected from cells adapted to respond to the physiological signal, wherein said cells comprising the cell layer are arranged in or on said biologic component prior to the step of implanting, wherein the physiological signal originates outside the device, and wherein said at least one sensor is arranged to detect said response. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
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Specification