Inhaler

• US 8,851,069 B2
• Filed: 04/21/2005
• Issued: 10/07/2014
• Est. Priority Date: 04/21/2004
• Status: Expired due to Fees

• Current Assignee: Innovata Biomed Limited (Vectura Group Ltd.)
• Original Assignee: Innovata Biomed Limited (Vectura Group Ltd.)
• Inventors: Peng, Weidong, Townsend, Christopher Andrew
• Primary Examiner(s): Yu, Justine
• Assistant Examiner(s): Stuart, Colin W
• Application Number:
  US11/578,935
• Publication Number:
  US 20070246044A1
• Time in Patent Office: 3,456 Days
• Field of Search: 128/203.12, 128/203.15, 128/203.23, 128/203.21, 128/203.22
• US Class Current: 128/203.15
• CPC Class Codes: A61M 15/0003 with means for dispensing more than one drug
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2206/14 Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
• CPC Class Codes: A61M 2206/16 Rotating swirling helical flow, e.g. by tangential inflows

Abstract

A dry powder inhaler comprises an airway (1) along which, in use, air is drawn from an upstream, inlet end (2) to a downstream, outlet end (3). The airway (1) includes a medicament presentation region (4) at which, in use, a dose of medicament is presented to the airway (1), a primary air inlet (10), and a barrel (5) extending from the medicament presentation region (4) to the outlet end (3) of the airway (1). The inlet end of the barrel (5) is of reduced internal dimension relative to the medicament presentation region (4) and relative to the outlet end of the barrel (5), such that the inlet end of the barrel (5) constitutes a constriction of the airway (1). At least one secondary air inlet (11) is disposed such that, in use, air enters the airway (1) from the secondary air inlet (11) in a direction that is substantially orthogonal to the direction of flow of air along said barrel (5).

Claims

1. A dry powder inhaler comprising an airway along which, in use, air is drawn from an upstream, inlet end to a downstream, outlet end, the airway including a medicament presentation region at which, in use, a dose of medicament is presented to the airway, the medicament presentation region having a primary air inlet, and a barrel extending from the medicament presentation region to an outlet end of the airway, an inlet end of the barrel being of reduced internal dimension relative to the medicament presentation region and relative to the outlet end of the airway, such that the inlet end of the barrel constitutes a constriction of the airway;

wherein the medicament presentation region is further provided with at least one secondary air inlet from which, in use, air enters the medicament presentation region in a direction that is substantially orthogonal to a flow of air into the medicament presentation region from the primary air inlet and to a direction of flow of air along said barrel, such that the air flows from the primary and secondary air inlets meet within the medicament presentation region, at which point the air flow from the secondary air inlet has a component of motion that is orthogonal to the air flow from the primary air inlet;

wherein a ratio of the cross-sectional areas of the primary and secondary air inlets is between 5;

1 and 2;

1.

2. An inhaler as claimed in claim 1, wherein the medicament presentation region of the airway comprises a substantially enclosed chamber having walls, the walls of the substantially enclosed chamber defining the primary and secondary air inlets.

3. An inhaler as claimed in claim 2, wherein medicament is presented to the airway by virtue of being delivered to a recess or opening in a wall of the chamber.

4. An inhaler as claimed in claim 2, wherein the primary air inlet has the form of a slot in a wall of the chamber.

5. An inhaler as claimed in claim 2, wherein the primary air inlet has the form of a slot in a wall of the chamber and the slot is disposed transverse to a longitudinal axis of the barrel.

6. An inhaler as claimed in claim 2, wherein the primary air inlet has the form of a slot formed in a wall of the chamber that is opposite to that to which the dose of medicament is presented, such that air is drawn into the chamber with a component of its motion that is directed towards the wall of the chamber at which the medicament is presented.

7. An inhaler as claimed in claim 2, wherein the secondary air inlet has the form of a slot.

8. An inhaler as claimed in claim 2, wherein the secondary air inlet is provided in a wall of the chamber that is orthogonal to a wall at which the medicament is presented.

9. An inhaler as claimed in claim 1, wherein the inlet end of the barrel has an internal diameter of from 2 mm to 4 mm, and an outlet end of the barrel has an internal diameter of from 4 mm to 8 mm.

10. An inhaler as claimed in claim 1, wherein the barrel has internal walls that are provided with grooves or fins.

11. An inhaler as claimed in claim 1, wherein the cross-sectional area of the primary air inlet is greater than 2 mm².

12. An inhaler as claimed in claim 1, wherein the cross-sectional area of the primary air inlet is less than 10 mm².

13. An inhaler as claimed in claim 1, wherein the cross-sectional area of the secondary air inlet is greater than 0.5 mm².

14. An inhaler as claimed in claim 1, wherein the cross-sectional area of the secondary air inlet is less than 5 mm².

15. An inhaler as claimed in claim 1, wherein the primary and secondary air inlets are positioned such that, in normal use, they avoid occlusion by a user.

16. A dry powder inhaler as claimed in claim 1 wherein a diameter of the barrel increases gradually from the inlet end to an outlet end of the barrel.

17. An inhaler as claimed in claim 16, which is charged with a medicament selected from β

₂-agonists, non-selective beta-stimulants, xanthine bronchodilators, anticholinergics, mast cell stabilisers, bronchial anti-inflammatory agents, and steroids.

18. An inhaler as claimed in claim 16, which comprises a plurality of separate airways along which, in use, air is drawn from an upstream, inlet end to a downstream, outlet end, each airway including a medicament presentation region at which, in use, a dose of medicament is presented to the airway, each medicament presentation region having a primary air inlet, and a barrel extending from its respective medicament presentation region to the respective outlet end of the airway, an inlet end of each barrel being of reduced internal dimension relative to the respective medicament presentation region and relative to a respective outlet end of the barrel, such that each inlet end of the barrels constitutes a constriction of the respective airway;

wherein each medicament presentation region is further provided with at least one secondary air inlet from which, in use, air enters the medicament presentation regions in a direction that is substantially orthogonal to a flow of air into the medicament presentation regions from the primary air inlets and to a direction of flow of air along said barrels.

19. An inhaler as claimed in claim 18, which is charged with a combination of medicaments selected from the group consisting of beclomethasone and formoterol;

beclomethasone and salmeterol;

fluticasone and formoterol;

fluticasone and salmeterol;

budesonide and formoterol;

budesonide and salmeterol;

flunisolide and formoterol;

flunisolide and salmeterol;

ciclesonide and salmeterol;

ciclesonide and formoterol;

mometasone and salmeterol; and

mometasone and formoterol.

20. An inhaler as claimed in claim 1, which is charged with a medicament selected from β

₂-agonists, non-selective beta-stimulants, xanthine bronchodilators, anticholinergics, mast cell stabilisers, bronchial anti-inflammatory agents, and steroids.

21. An inhaler as claimed in claim 1, which comprises a plurality of separate airways along which, in use, air is drawn from an upstream, inlet end to a downstream, outlet end, each airway including a medicament presentation region at which, in use, a dose of medicament is presented to the airway, each medicament presentation region having a primary air inlet, and a barrel extending from its respective medicament presentation region to the respective outlet end of the airway, an inlet end of each barrel being of reduced internal dimension relative to the respective medicament presentation region and relative to a respective outlet end of the barrel, such that each inlet end of the barrels constitutes a constriction of the respective airway;

wherein each medicament presentation region is further provided with at least one secondary air inlet from which, in use, air enters the medicament presentation regions in a direction that is substantially orthogonal to a flow of air into the medicament presentation regions from the primary air inlets and to a direction of flow of air along said barrels.

22. An inhaler as claimed in claim 21, which is charged with a combination of medicaments selected from the group consisting of beclomethasone and formoterol;

beclomethasone and salmeterol;

fluticasone and formoterol;

fluticasone and salmeterol;

budesonide and formoterol;

budesonide and salmeterol;

flunisolide and formoterol;

flunisolide and salmeterol;

ciclesonide and salmeterol;

ciclesonide and formoterol;

mometasone and salmeterol; and

mometasone and formoterol.

23. An inhaler as claimed in claim 1 wherein the primary air inlet is positioned on the airway for exposure to ambient air and allows air to flow external of the inhaler into the medicament presentation region during use.

24. A dry powder inhaler comprising an airway along which, in use, air is drawn from an upstream, inlet end to a downstream, outlet end, the airway including a medicament presentation region at which, in use, a dose of medicament is presented to the airway, the medicament presentation region having a primary air inlet, and a barrel extending from the medicament presentation region to an outlet end of the airway, an inlet end of the barrel being of reduced internal dimension relative to the medicament presentation region and relative to the outlet end of the airway, such that the inlet end of the barrel constitutes a constriction of the airway;

wherein the medicament presentation region is further provided with at least one secondary air inlet, and a ratio of the cross-sectional areas of the primary and secondary air inlets is between 5;

1 and 2;

1.

25. An inhaler as claimed in claim 24, wherein the cross-sectional area of the primary air inlet is greater than 2 mm².

26. An inhaler as claimed in claim 24, wherein the cross-sectional area of the primary air inlet is less than 10 mm².

27. An inhaler as claimed in claim 24, wherein the cross-sectional area of the secondary air inlet is greater than 0.5 mm².

28. An inhaler as claimed in claim 24, wherein the cross-sectional area of the secondary air inlet is less than 5 mm².

29. An inhaler as claimed in claim 24, wherein the primary and secondary air inlets are positioned such that, in normal use, they avoid occlusion by a user.

30. An inhaler as claimed in claim 24, which is charged with a medicament selected from β

₂-agonists, non-selective beta-stimulants, xanthine bronchodilators, anticholinergics, mast cell stabilisers, bronchial anti-inflammatory agents, and steroids.

31. An inhaler as claimed in claim 24, which comprises a plurality of separate airways along which, in use, air is drawn from an upstream, inlet end to a downstream, outlet end, each airway including a medicament presentation region at which, in use, a dose of medicament is presented to the airway, each medicament presentation region having a primary air inlet, and a barrel extending from its respective medicament presentation region to the respective outlet end of the airway, an inlet end of each barrel being of reduced internal dimension relative to the respective medicament presentation region and relative to a respective outlet end of the barrel, such that each inlet end of the barrels constitutes a constriction of the respective airway;

wherein each medicament presentation region is further provided with at least one secondary air inlet from which, in use, air enters the medicament presentation regions in a direction that is substantially orthogonal to a flow of air into the medicament presentation regions from the primary air inlets and to a direction of flow of air along said barrels.

32. An inhaler as claimed in claim 31, which is charged with a combination of medicaments selected from the group consisting of beclomethasone and formoterol;

beclomethasone and salmeterol;

fluticasone and formoterol;

fluticasone and salmeterol;

budesonide and formoterol;

budesonide and salmeterol;

flunisolide and formoterol;

flunisolide and salmeterol;

ciclesonide and salmeterol;

ciclesonide and formoterol;

mometasone and salmeterol; and

mometasone and formoterol.