Methods for implanting a soft gel shunt in the suprachoroidal space

• US 8,852,137 B2
• Filed: 12/23/2011
• Issued: 10/07/2014
• Est. Priority Date: 11/15/2010
• Status: Active Grant

• Current Assignee: AqueSys, Inc. (Abbvie Incorporated)
• Original Assignee: AqueSys, Inc. (Abbvie Incorporated)
• Inventors: Horvath, Christopher, Bache, Ronald D., Romoda, Laszlo O., Grabner, Guenther, Reitsamer, Herbert A., Samples, John R.
• Primary Examiner(s): Wiest, Philip R
• Application Number:
  US13/336,758
• Publication Number:
  US 20120165723A1
• Time in Patent Office: 1,019 Days
• Field of Search: 604 8- 10, 604/272, 604/523, 604540-541, 128/898, 606/108, 606/107, 606/166, 606/167, 623/6.12, 623/1.11, 623/1.41, 623/4.1
• US Class Current: 604/8
• CPC Class Codes: A61F 2210/0061 swellable
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002

Abstract

The invention generally relates to methods for implanting a soft gel shunt in the suprachoroidal space. In certain embodiments, methods of the invention involve inserting into the eye a hollow shaft configured to hold a soft gel intraocular shunt, deploying the soft gel shunt from the hollow shaft such that the shunt forms a passage from the anterior chamber of the eye to the suprachoroidal space of the eye, and withdrawing the hollow shaft from the eye.

Claims

1. A method of deploying an intraocular shunt into an eye, the method comprising the steps of:

inserting into the eye a hollow shaft, having a curved configuration and a less curved configuration, less curved than the curved configuration, and holding a soft gel intraocular shunt;

exposing the soft gel shunt, out of the shaft along a scleral spur of the eye while the shaft is in the curved configuration along the scleral spur such that the shunt forms a passage with a proximal portion of shunt residing in the anterior chamber of the eye and a distal portion of the shunt residing in the suprachoroidal space of the eye; and

withdrawing the shaft, in the less curved configuration, from the eye.

2. The method according to claim 1, wherein the exposing step comprises allowing the shunt to be guided along the scleral spur of the eye.

3. The method of claim 1, wherein the inserting step comprises insertion of the hollow shaft into the cornea.

4. The method of claim 3, wherein the insertion comprises inserting the hollow shaft into the eye anterior to the corneal limbus.

5. The method of claim 3, wherein the insertion comprises inserting the hollow shaft into the eye posterior to the corneal limbus.

6. The method of claim 1, wherein the inserting occurs without removing a portion of the trabecular meshwork or the iris.

7. The method of claim 1, wherein the method is performed without inducing subconjunctival blebbing.

8. The method according to claim 1, wherein the shunt drains fluid from an anterior chamber into an episcleral vessel complex of the eye.

9. The method according to claim 1, wherein the shunt comprising a material that has an elasticity modulus that is substantially the same as an elasticity modulus of scleral tissue of the eye.

10. The method according to claim 1, wherein the shunt comprises a hollow body, wherein at least a portion of the body is comprised of a flexible material that allows for fluctuation of an inner diameter of the portion of the shaft based upon pressure exerted from surrounding tissue and/or fluid in the organ.

11. The method according to claim 10, wherein the at least a portion of the body that is comprised of the flexible material is a distal portion of the body, the distal portion comprising a distal end of the body disposed in the suprachoroidal space.

12. The method according to claim 10, wherein the at least a portion of the body that is comprised of the flexible material is a middle portion between a proximal end and a distal end of the body.

13. The method according to claim 10, wherein an entire length of the shaft comprises the flexible material.

14. The method according to claim 1, wherein the shunt comprises a body having a variable inner diameter that increases along the length of the body length from the inlet to the outlet.

15. The method according to claim 14, wherein the inner diameter continuously increases along the length of the body.

16. The method according to claim 14, wherein the inner diameter remains constant along portions of the length of the body.

17. The method according to claim 1, wherein inserting the hollow shaft comprises moving at least a portion of the shaft out of a hollow sleeve, such that the hollow shaft changes from the less curved configuration in the sleeve to the curved configuration out of the sleeve.

18. The method according to claim 1, wherein inserting the hollow shaft comprises forming a curved pathway along a scleral spur.

19. The method according to claim 1, wherein during the withdrawing, the shaft is withdrawn into a hollow sleeve and changes from the curved configuration to the less curved configuration.

20. A method of deploying an intraocular shunt into an eye, the method comprising the steps of:

inserting into the eye a hollow shaft, having a curved configuration and a less curved configuration, less curved than the curved configuration, and holding an intraocular shunt, wherein the shunt comprises a material;

exposing the shunt out of the shaft, while the shaft is in the curved configuration, such that the shunt forms a curved passage with a proximal portion of shunt residing in the anterior chamber of the eye and a distal portion of the shunt residing in the suprachoroidal space of the eye; and

withdrawing the shaft, in the less curved configuration, from the eye.

21. The method according to claim 20, wherein the material has an elasticity modulus that is substantially identical to the elasticity modulus of the tissue surrounding the shunt.

22. The method according to claim 20, wherein the material has an elasticity modulus that is greater than the elasticity modulus of the tissue surrounding the shunt.

23. The method of claim 20, wherein the inserting step comprises insertion of the hollow shaft into the eye.

24. The method of claim 23, wherein the insertion occurs anterior to the corneal limbus.

25. The method of claim 23, wherein the insertion occurs posterior to the corneal limbus.

26. The method of claim 20, wherein the inserting occurs without removing a portion of the trabecular meshwork or the iris.

27. The method of claim 20, wherein the method is performed without inducing subconjunctival blebbing.

28. The method according to claim 20, wherein the shunt drains fluid from an anterior chamber into an episcleral vessel complex of the eye.

29. The method according to claim 20, wherein inserting the hollow shaft comprises moving at least a portion of the shaft out of a hollow sleeve, such that the hollow shaft changes from the less curved configuration in the sleeve to the curved configuration out of the sleeve.

30. The method according to claim 20, wherein inserting the hollow shaft comprises forming a curved pathway along the scleral spur.

31. The method according to claim 20, wherein during the withdrawing, the shaft is withdrawn into a hollow sleeve and changes from the curved configuration to the less curved configuration.