Renal neuromodulation via drugs and neuromodulatory agents and associated systems and methods
First Claim
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1. A method for treating a human patient diagnosed with hypertension, the method comprising:
- intravascularly positioning a catheter within a renal artery of a human patient and proximate to renal nerves of the patient; and
delivering a neuromodulatory agent via the catheter to tissue external to the renal artery and in contact with or adjacent to the renal nerves, wherein the neuromodulatory agent reduces neural traffic along the renal nerves to and/or from a kidney of the patient,wherein reducing the neural traffic results in a therapeutically beneficial reduction in blood pressure of the patient.
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Abstract
Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
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12 Claims
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1. A method for treating a human patient diagnosed with hypertension, the method comprising:
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intravascularly positioning a catheter within a renal artery of a human patient and proximate to renal nerves of the patient; and delivering a neuromodulatory agent via the catheter to tissue external to the renal artery and in contact with or adjacent to the renal nerves, wherein the neuromodulatory agent reduces neural traffic along the renal nerves to and/or from a kidney of the patient, wherein reducing the neural traffic results in a therapeutically beneficial reduction in blood pressure of the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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