Methods and systems for providing therapies into the pericardial space
First Claim
1. A method of accessing the pericardial space between a heart and its pericardium to deliver a pharmacologic agent for the treatment of ischemia to the heart, the method comprising the steps of:
- advancing an infusion catheter to dispose a distal catheter segment having a distal infusion catheter lumen end opening in the pericardial space;
attaching a proximal connector of the infusion catheter to an infusion pump having a reservoir containing the pharmacologic agent;
detecting an ischemic state of the heart; and
delivering the pharmacologic agent for the treatment of ischemia from the reservoir into the pericardial space to counter the detected ischemic state.
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Accused Products
Abstract
Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver a pharmacologic agent, particularly a NO-donor drug, to the heart are disclosed. A proximal connector of an infusion catheter is coupled to an infusion pump, and a distal catheter segment having a distal infusion catheter lumen end opening is disposed in the pericardial space. The implantable infusion pump is operable in conjunction with an implantable ischemia monitor to monitor the ischemic state and trigger delivery or regulate the periodic delivery of the pharmacologic agent to optimally treat ischemia. The patient may operate a patient activator that the patient when feeling ischemia symptoms to transmit a signal that is received by the implantable infusion pump and triggers delivery of a bolus and/or continuous infusion.
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Citations
22 Claims
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1. A method of accessing the pericardial space between a heart and its pericardium to deliver a pharmacologic agent for the treatment of ischemia to the heart, the method comprising the steps of:
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advancing an infusion catheter to dispose a distal catheter segment having a distal infusion catheter lumen end opening in the pericardial space; attaching a proximal connector of the infusion catheter to an infusion pump having a reservoir containing the pharmacologic agent; detecting an ischemic state of the heart; and delivering the pharmacologic agent for the treatment of ischemia from the reservoir into the pericardial space to counter the detected ischemic state. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 21)
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12. A method of transvenously accessing the pericardial space between a heart and its pericardium to deliver a NO-donor drug to the heart, the method comprising the steps of:
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advancing an infusion catheter to dispose a distal catheter segment having a distal infusion catheter lumen end opening in the pericardial space; attaching a proximal connector of the infusion catheter to an infusion pump; detecting a condition of the heart; and delivering a bolus of NO-donor drug. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 22)
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Specification