Biocompatible implants and methods of making and attaching the same
First Claim
1. A silicone article treated with a biocompatible compound that facilitates bonding to living tissue, comprising:
- a silicone substrate having (i) an original surface plane;
(ii) an ablated and recessed first activated surface formed by irradiation with laser light at a wavelength and power sufficient to eject organic species from the silicone substrate by breaking Si—
C bonds of the substrate below the original surface plane, the first activated surface being below the original surface plane; and
(iii) an unrecessed second activated surface, adjacent the first surface, having thereon an adherent layer comprised of the ejected organic species; and
at least one compound capable of binding to one or more integrins, coupled to the substrate.
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Accused Products
Abstract
The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attaching such implants are also provided.
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Citations
26 Claims
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1. A silicone article treated with a biocompatible compound that facilitates bonding to living tissue, comprising:
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a silicone substrate having (i) an original surface plane;
(ii) an ablated and recessed first activated surface formed by irradiation with laser light at a wavelength and power sufficient to eject organic species from the silicone substrate by breaking Si—
C bonds of the substrate below the original surface plane, the first activated surface being below the original surface plane; and
(iii) an unrecessed second activated surface, adjacent the first surface, having thereon an adherent layer comprised of the ejected organic species; andat least one compound capable of binding to one or more integrins, coupled to the substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A biocompatible, implantable prosthesis, comprising:
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an implantable prosthesis partially or completely covered by a silicone having (i) an original surface plane;
(ii) an ablated and recessed first activated surface having been irradiated with laser light at a wavelength and power sufficient to eject organic species from the silicone substrate by breaking Si—
C bonds of the substrate below the original surface plane, the first activated surface being below the original surface plane; and
(iii) an unrecessed second activated surface, adjacent the first surface, having thereon an adherent layer comprised of the ejected organic species; andat least one biocompatible compound capable of binding to one or more integrins, coupled to at least one activated surface. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of making a biocompatible, implantable prosthesis, comprising:
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providing an implantable prosthesis; partially or completely covering the implantable prosthesis with a silicone having an original surface plane; irradiating the silicone with laser light at a wavelength and power sufficient to eject organic species from the silicone by breaking Si—
C bonds of the silicone below the original surface plane, thereby forming a recessed first activated surface beneath the original surface plane;forming an adherent layer on an unrecessed second activated surface, adjacent the first activate surface, with the ejected organic species; and coupling at least one biocompatible compound capable of binding to one or more integrins to at least one activated surface. - View Dependent Claims (23, 24, 25, 26)
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Specification