Measuring device and methods for use therewith

• US 8,852,510 B2
• Filed: 03/08/2013
• Issued: 10/07/2014
• Est. Priority Date: 05/30/2004
• Status: Active Grant

• Current Assignee: Agamatrix Incorporated (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Original Assignee: Agamatrix Incorporated (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Inventors: Harding, Ian, Iyengar, Sridhar G., Wei, Baoguo, Diamond, Steven, Forest, Martin
• Primary Examiner(s): Hyun, Paul
• Application Number:
  US13/790,822
• Publication Number:
  US 20140001046A1
• Time in Patent Office: 578 Days
• Field of Search: 204/403.02, 422/82.01, 422/82.02
• US Class Current: 422/82.02
• CPC Class Codes: G01N 27/28 Electrolytic cell components
• CPC Class Codes: G01N 27/3271 Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 27/3273 Devices therefor, e.g. test element readers, circuitry details not specific to biochemical electrodes G01N33/4875
• CPC Class Codes: G01N 27/403 Cells and electrode assemblies
• CPC Class Codes: G01N 33/50 Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing measuring or testing processes involving enzymes or microorganisms, compositions or test papers therefor; processes for forming such compositions, condition responsive control in microbiological or enzymological processes C12Q

Abstract

The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analysis of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.

Claims

1. An apparatus for use with a reaction cell having a first electrode and a second electrode, the apparatus comprising

a voltage source providing a controllable voltage to a contact for the first electrode;

a voltage sensor sensing voltage provided to the contact for the first electrode;

an amplifier; and

a plurality of switches each switchable between first and second positions,

wherein when said plurality of switches is in a first switch configuration the amplifier measures current through a contact for the second electrode, thereby measuring current through the reaction cell, and wherein when the switches are in a second switch configuration the amplifier permits measurement of a voltage between the contacts for the first and second electrodes, wherein the plurality of switches comprises first, second and third switches, the first switch connecting the contact for the second electrode and an inverting input of the amplifier, the second switch connecting the contact for the second electrode and a non-inverting input of the amplifier, and the third switch connecting the non-inverting input of the amplifier and a reference voltage, and wherein the first position is defined by the first and third switches being closed and the second switch being open, and the second position is defined by the first and third switches being open and the second switch being closed.