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GLP-1 Fusion Peptides

  • US 8,853,159 B2
  • Filed: 05/29/2012
  • Issued: 10/07/2014
  • Est. Priority Date: 09/22/2005
  • Status: Expired due to Fees
First Claim
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1. A fusion peptide comprisinga component (I) N-terminally having a sequence according to formula I:

  • His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-X(I) (SEQ ID NO;

         43), wherein X is NH2 or Gly-OH, or a sequence having 95% sequence identity with SEQ ID NO;

    43;

    a component (II) C-terminally having a peptide sequence containing SEQ ID NO;

    22 or sequence having 90% sequence identity with SEQ ID NO;

    22 (RRDFPEEVAI); and

    a component (III) C-terminally having a sequence according to formula I (SEQ ID NO;

         43) or a sequence having 95% sequence identity with SEQ ID NO;

    43;

    and its pharmaceutically active salts.

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