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Acoustically induced blood stasis and in vivo optical spectroscopy

  • US 8,855,738 B2
  • Filed: 08/17/2006
  • Issued: 10/07/2014
  • Est. Priority Date: 08/18/2005
  • Status: Active Grant
First Claim
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1. A method for diagnosis of a region of interest in a patient, the method comprising:

  • (a) causing an oxy/deoxyhemoglobin shift in the region of interest using an ultrasound signal;

    (b) performing optical spectroscopy on the region of interest to obtain a ratio of optical absorption values at different wavelengths, a change of the ratio over time representing the oxy/deoxyhemoglobin shift; and

    (c) determining whether the region of interest contains tumor tissue by determining whether the ratio obtained in step (b) correlates with the ultrasound signal used in step (a), wherein a correlation between the ratio and the ultrasound signal is higher in a non-tumor case than in a tumor case.

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