Acoustically induced blood stasis and in vivo optical spectroscopy
First Claim
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1. A method for diagnosis of a region of interest in a patient, the method comprising:
- (a) causing an oxy/deoxyhemoglobin shift in the region of interest using an ultrasound signal;
(b) performing optical spectroscopy on the region of interest to obtain a ratio of optical absorption values at different wavelengths, a change of the ratio over time representing the oxy/deoxyhemoglobin shift; and
(c) determining whether the region of interest contains tumor tissue by determining whether the ratio obtained in step (b) correlates with the ultrasound signal used in step (a), wherein a correlation between the ratio and the ultrasound signal is higher in a non-tumor case than in a tumor case.
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Abstract
Ultrasound-induced blood stasis has been observed for more than thirty years. Most of the literature has been focused on the health risks associated with this phenomenon and methods employed to prevent stasis from occurring during ultrasound imaging. To date, experimental observations have been either in vitro or invasive. The current work demonstrates ultrasound-induced blood stasis in murine tumor and nontumor tissue, observed through noninvasive measurements of optical spectroscopy, and discusses possible diagnostic uses for this previously undesirable effect of ultrasound.
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Citations
19 Claims
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1. A method for diagnosis of a region of interest in a patient, the method comprising:
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(a) causing an oxy/deoxyhemoglobin shift in the region of interest using an ultrasound signal; (b) performing optical spectroscopy on the region of interest to obtain a ratio of optical absorption values at different wavelengths, a change of the ratio over time representing the oxy/deoxyhemoglobin shift; and (c) determining whether the region of interest contains tumor tissue by determining whether the ratio obtained in step (b) correlates with the ultrasound signal used in step (a), wherein a correlation between the ratio and the ultrasound signal is higher in a non-tumor case than in a tumor case. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A system for diagnosis of a region of interest in a patient, the system comprising:
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(a) an ultrasound device configured to cause an oxy/deoxyhemoglobin shift in the region of interest using an ultrasound signal; and (b) a diagnostic device configured to perform optical spectroscopy on the region of interest to obtain a ratio of optical absorption values at different wavelengths, a change of the ratio over time representing the oxy/deoxyhemoglobin shift, and configured to determine whether the region of interest contains tumor tissue by determining whether the ratio correlates with the ultrasound signal, wherein the diagnostic device is configured to take into account that a correlation between the ratio and the ultrasound signal is higher in a non-tumor case than in a tumor case; and (c) wherein the diagnostic device includes a computer display comprising a display area for tumor correlation and a display area for non-tumor correlation, said display device displaying at least one of the correlations for non-tumor tissue and for tumor tissue as a correlation metric indicative of the presence of tumor or non-tumor tissue at the region of interest. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19)
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Specification