Non-contrast magnetic resonance perfusion imaging
First Claim
Patent Images
1. A magnetic resonance imaging (MRI) system comprising:
- an MRI gantry including a static magnet, gradient magnet coils and at least one radio frequency (RF) coil defining a patient imaging volume into which a chest region of a patient is located; and
RF receiver and transmitter circuits coupled to said at least one RF coil;
control circuits connected to said gantry and to said RF receiver and transmitter circuits, said control circuits having an operator display and an operator control input port for configuring and operating said MRI system to acquire and process MRI data from said patient,said control circuits being configured(i) to acquire first, second and third MRI data sets for a same region within the chest region without use of a contrast-enhancing chemical agent by performing the following three data acquisition sub-sequences within one scan sequence, (A) using a non-selective inversion pulse without a selective inversion pulse, (B) using a non-selective inversion pulse and a selective inversion pulse, and (C) using a selective inversion pulse without a non-selective inversion pulse;
(ii) to repeat the acquisition of said first, second and third MRI data sets for each of plural different black blood time to inversion (BBTI) values, wherein three data acquisition sub-sequences are performed respectively for a same BBTI value;
(iii) image processing circuits configured to generate first, second and third images for the same region for each of plural different BBTI values based on the first, second and third MRI data sets and to generate a processed cardiac perfusion image by differentially combining respectively corresponding pixels of the first, second and third images; and
(iv) an output circuit for outputting said processed cardiac perfusion image for digital storage or digital data transmission.
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Abstract
A magnetic resonance imaging (MRI) system acquires MRI data within one patient breath-hold sufficient to generate (a) at least one tag-off first type non-contrast cardiac perfusion image using a data acquisition sub-sequence including a non-selective IR (inversion recovery) pulse and (b) at least one tag-on second type non-contrast cardiac perfusion image using a data acquisition sub-sequence including a non-selective IR pulse and a spatially selective IR pulse. A set of registered tag-on and tag-off images are differentially combined to produce an accurate cardiac perfusion image.
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Citations
22 Claims
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1. A magnetic resonance imaging (MRI) system comprising:
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an MRI gantry including a static magnet, gradient magnet coils and at least one radio frequency (RF) coil defining a patient imaging volume into which a chest region of a patient is located; and RF receiver and transmitter circuits coupled to said at least one RF coil; control circuits connected to said gantry and to said RF receiver and transmitter circuits, said control circuits having an operator display and an operator control input port for configuring and operating said MRI system to acquire and process MRI data from said patient, said control circuits being configured (i) to acquire first, second and third MRI data sets for a same region within the chest region without use of a contrast-enhancing chemical agent by performing the following three data acquisition sub-sequences within one scan sequence, (A) using a non-selective inversion pulse without a selective inversion pulse, (B) using a non-selective inversion pulse and a selective inversion pulse, and (C) using a selective inversion pulse without a non-selective inversion pulse; (ii) to repeat the acquisition of said first, second and third MRI data sets for each of plural different black blood time to inversion (BBTI) values, wherein three data acquisition sub-sequences are performed respectively for a same BBTI value; (iii) image processing circuits configured to generate first, second and third images for the same region for each of plural different BBTI values based on the first, second and third MRI data sets and to generate a processed cardiac perfusion image by differentially combining respectively corresponding pixels of the first, second and third images; and (iv) an output circuit for outputting said processed cardiac perfusion image for digital storage or digital data transmission. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 19, 20, 21, 22)
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2. A magnetic resonance imaging (MRI) system comprising:
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an MRI gantry including a static magnet, gradient magnet coils and at least one radio frequency (RF) coil defining a patient imaging volume into which the chest region of a patient is located; and RF receiver and transmitter circuits coupled to said at least one RF coil; control circuits connected to said gantry and to said RF receiver and transmitter circuits, said control circuits having an operator display and an operator control input port for configuring and operating said MRI system to acquire and process MRI data from said patient, said control circuits being configured (i) to acquire MRI data sufficient to generate without use of a contrast-enhancing chemical agent (a) a first type image using a data acquisition sub-sequence including an IR (inversion recovery) pulse and (b) a second type image using a data acquisition sub-sequence including an IR pulse, the first type image being different from the second type image, and (ii) to repeat the acquisition of said MRI data for each of plural different black blood time to inversion (BBTI) values; image processing circuits configured to combine respectively corresponding complex-values of the first type image pixels and second type image pixels to produce a resultant cardiac perfusion image I in accordance with the following formula
Ii=(θ
o−
min(θ
o,|Ai−
Bi|))F(max(|Ai|,|Bi|),TBBTI)where; Ai and Bi are complex number values of a pixel at pixel location I of a first type image and a second type image, respectively, θ
o is a threshold value, andF is a continuous threshold function of |Ai| and |Bi| and TBBTI black blood time to inversion (BBTI), wherein; said control circuits are further configured to acquire MRI data within one patient breath-hold sufficient to generate without use of a contrast-enhancing chemical agent (c) at least one tag-on third type cardiac perfusion image using a data acquisition sub-sequence including a spatially selective IR pulse, and said image processing circuits are further configured to combine respectively corresponding complex-values of the first type image pixels and third type image pixels to produce a resultant cardiac perfusion image I in accordance with the following formula
Ii=|Ai−
Bi|F(|Ci−
Ai|,TBBI)where Ai, Bi and Ci are complex number values of a pixel at pixel location i of a first type image, a second type image and a third type image, respectively, and TBBTI is the black blood time to inversion (BBTI). - View Dependent Claims (3)
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4. A magnetic resonance imaging (MRI) system, comprising:
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an MRI gantry including a static magnet, gradient magnet coils and at least one radio frequency (RF) coil defining a patient imaging volume into which the chest region of a patient is located; RF receiver and transmitter circuits coupled to said at least one RF coil; control circuits connected to said gantry and to said RF receiver and transmitter circuits, said control circuits having an operator display and an operator control input port for configuring and operating said MRI system to acquire and process MRI data from said patient, said control circuits being configured to acquire MRI data within one patient breath-hold sufficient to generate without use of a contrast-enhancing chemical agent (a) at least one tag-off first type cardiac perfusion image using a data acquisition sub-sequence including a non-selective IR (inversion recovery) pulse and (b) at least one tag-on second type cardiac perfusion image using a data acquisition sub-sequence including a non-selective IR pulse and a spatially selective IR pulse, and image processing circuits configured to generate processed cardiac perfusion image pixels by differentially combining respectively corresponding pixels of tag-on and tag-off images acquired for each BBTI value; wherein said image processing circuits are configured to combine respectively corresponding complex-values of the first type and second type image pixels to produce a resultant cardiac perfusion image I in accordance with the following formula
Ii=(θ
o−
min(θ
o,|Ai−
Bi|))F(max(|Ai|,|Bi|),TBBTI)where; Ai and Bi are complex number values of a pixel at pixel location i of a first type image and a second type image, respectively, θ
o is a threshold value, andF is a continuous threshold function of |Ai| and |Bi| and TBBTI black blood time to inversion (BBTI); wherein said image processing circuits are configured to define the function F as a sigmoid function, and wherein said sigmoid function F is defined as; - View Dependent Claims (5, 6)
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15. A magnetic resonance imaging (MRI) method comprising:
using an MRI gantry including a static magnet, gradient magnet coils and at least one radio frequency (RF) coil defining a patient imaging volume into which the chest region of a patient is located, RF receiver and transmitter circuits coupled to said at least one RF coil (i) to acquire MRI data sufficient to generate, within one patient breath-hold, without use of a contrast-enhancing chemical agent, (a) a first image using a data acquisition sub-sequence including an IR (inversion recovery) pulse, (b) a second image using a data acquisition sub-sequence including an IR pulse, and (c) a third type image using a data acquisition sub-sequence including a spatially selective IR pulse, the first, second and third type images being different from each other, wherein each of said first, second and third data acquisition sub-sequences is one of the following three types (A) using a non-selective inversion pulse without a selective inversion pulse, (B) using a non-selective inversion pulse and a selective inversion pulse, and (C) using a selective inversion pulse without a non-selective inversion pulse; (ii) to repeat the acquisition of said MRI data for each of plural different black blood time to inversion (BBTI) values; (iii) to generate first, second and third images for the same region for each of plural different BBTI values based on the acquired MRI data, and to generate a processed cardiac perfusion image, by differentially combining respectively corresponding pixels of the first, second and third images; and (iv) to output said processed cardiac perfusion image for digital storage or digital data transmission. - View Dependent Claims (16)
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17. A magnetic resonance imaging (MRI) method using an MRI gantry including a static magnet, gradient magnet coils and at least one radio frequency (RF) coil defining a patient imaging volume into which the chest region of a patient is located, RF receiver and transmitter circuits coupled to said at least one RF coil to acquire MRI data within one patient breath-hold sufficient to generate without use of a contrast-enhancing chemical agent (a) at least one tag-off first type cardiac perfusion image using a data acquisition sub-sequence including a non-selective IR (inversion recovery) pulse and (b) at least one tag-on second type cardiac perfusion image using a data acquisition sub-sequence including a non-selective IR pulse and a spatially selective IR pulse, and
using at least one image processor to generate processed cardiac perfusion image pixels by differentially combining respectively corresponding pixels of tag-on and tag-off images acquired for each BBTI value; -
wherein said image processor combines respectively corresponding complex-values of the first type image pixels and second type image pixels to produce a resultant cardiac perfusion image I in accordance with the following formula
Ii=(θ
o−
min(θ
o,|Ai−
Bi|))F(max(|Ai|,|Bi|),TBBTI)where; Ai and Bi are complex number values of a pixel at pixel location i of a first type image and a second type image, respectively, θ
o is a threshold value, andF is a continuous threshold function of |Ai| and |Bi| and TBBTI black blood time to inversion (BBTI), and wherein F is defined as; - View Dependent Claims (18)
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Specification