Neural stimulation devices and systems for treatment of chronic inflammation
First Claim
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1. A system for treating chronic inflammation in a patient, the system comprising:
- an implantable microstimulator configured for implantation around a cervical portion of a vagus nerve to modulate inflammation by applying a low duty-cycle stimulation;
a charger configured to be worn around the patient'"'"'s neck and to charge the implantable microstimulator, the charger comprising an energizer coil configured to fit around the patient'"'"'s neck, the charger having an open configuration and a closed configuration, wherein in the open configuration the charger is configured to be placed around the patients neck and the energizer coil is an open circuit, wherein in the closed configuration the charger is configured to be secured around the patient'"'"'s neck and the energizer coil is a closed circuit that forms a solenoid loop around the patient'"'"'s neck; and
an external controller configured to set a dose amplitude and dose interval for the microstimulator.
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Abstract
A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject'"'"'s neck to rapidly (<10 minutes per week) charge an implanted microstimulator. The external controller may be configured as a prescription pad that controls the dosing and activity of the microstimulator.
585 Citations
21 Claims
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1. A system for treating chronic inflammation in a patient, the system comprising:
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an implantable microstimulator configured for implantation around a cervical portion of a vagus nerve to modulate inflammation by applying a low duty-cycle stimulation; a charger configured to be worn around the patient'"'"'s neck and to charge the implantable microstimulator, the charger comprising an energizer coil configured to fit around the patient'"'"'s neck, the charger having an open configuration and a closed configuration, wherein in the open configuration the charger is configured to be placed around the patients neck and the energizer coil is an open circuit, wherein in the closed configuration the charger is configured to be secured around the patient'"'"'s neck and the energizer coil is a closed circuit that forms a solenoid loop around the patient'"'"'s neck; and an external controller configured to set a dose amplitude and dose interval for the microstimulator. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for treating chronic inflammation in a patient, the system comprising:
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an implantable microstimulator configured for implantation around a cervical portion of a vagus nerve to modulate inflammation by applying low duty-cycle stimulation to the vagus nerve; a POD configured to hold the implantable microstimulator in contact with a patient'"'"'s vagus nerve; a charger configured to be worn around the patient'"'"'s neck and to charge the implantable microstimulator implanted within the patient'"'"'s neck region, the charger comprising an energizer coil configured to fit around the patient'"'"'s neck, the charger having an open configuration and a closed configuration, wherein in the open configuration the charger is configured to be placed around the patients neck and the energizer coil is an open circuit, wherein in the closed configuration the charger is configured to be secured around the patient'"'"'s neck and the energizer coins a closed circuit a solenoid loop around the patient'"'"'s neck; and an external controller configured to communicate with the microstimulator through the charger and to thereby set the dose amplitude and dose interval for the microstimulator, wherein microstimulator is configured to continuously modulate inflammation while charging by the charger for less than 10 minutes per week. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A system for treating chronic inflammation in a patient, the system comprising:
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an implantable, leadless microstimulator configured for implantation around a portion of a vagus nerve to modulate inflammation by applying low duty-cycle stimulation to the vagus nerve, the microstimulator comprising at least two electrically conductive contacts and a battery; and a POD configured to removably hold the microstimulator in electrical communication with a patient'"'"'s vagus nerve, the POD comprising a shell and a channel, the shell defining a cavity configured to encapsulate the microstimulator, the channel extending longitudinally through POD and configured to removably receive the vagus nerve, wherein the cavity is also configured to encapsulate the electrically conductive contacts. - View Dependent Claims (16, 17, 18, 19, 20, 21)
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Specification