Ventilatory assistance for treatment of cardiac failure and cheyne-stokes breathing

• US 8,857,430 B2
• Filed: 08/08/2013
• Issued: 10/14/2014
• Est. Priority Date: 05/22/1998
• Status: Expired due to Fees

• Current Assignee: ResMed Pty Ltd. (ResMed Incorporated)
• Original Assignee: Resmed Limited (ResMed Incorporated)
• Inventors: Berthon-Jones, Michael
• Primary Examiner(s): DOUGLAS, STEVEN O
• Application Number:
  US13/962,493
• Publication Number:
  US 20140069430A1
• Time in Patent Office: 432 Days
• Field of Search: 128/204.18, 128/204.21, 128/204.22, 128/204.23, 128/204.24, 128/204.26, 128/204.29, 128/205.11
• US Class Current: 128/204.23
• CPC Class Codes: A61M 16/00 Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes stimulating the respiratory movement by mechanical, pneumatic or electrical means, iron lungs combined with gas breathing means A61H31/00
• CPC Class Codes: A61M 16/0003 Accessories therefor, e.g. sensors, vibrators, negative pressure
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/0057 Pumps therefor
• CPC Class Codes: A61M 16/0069 the speed thereof being controlled by respiratory parameters, e.g. by inhalation
• CPC Class Codes: A61M 16/024 including calculation means, e.g. using a processor
• CPC Class Codes: A61M 16/0858 Pressure sampling ports
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2230/42 Rate

Abstract

Method and apparatus for the treatment of cardiac failure, Cheyne Stokes breathing or central sleep apnea are disclosed. A subject is provided with ventilatory support Respiratory airflow is determined. From the respiratory airflow are derived a measure of instantaneous ventilation and a measure of longterm average ventilation. A target ventilation is taken as 95% of the longterm average ventilation. The instantaneous ventilation is fed as the input signal to a clipped integral controller, with the target ventilation as the reference signal. The output of the controller determines the degree of ventilatory support. A third measure of ventilation, for example instantaneous ventilation low pass filtered with a time constant of 5 seconds, is calculated. Ventilatory support is in phase with the subject'"'"'s respiratory airflow to the fuzzy extent that this ventilation is above target, and at a preset rate conversely.

Claims

1. An apparatus for the treatment of cardiac failure, Cheyne-Stokes breathing or central sleep apnea, the apparatus comprising:

a controllable source of breathable gas at positive pressure;

means for delivering said breathable gas at positive pressure to a subject'"'"'s airway;

means for deriving a measure of respiratory airflow of the subject; and

a servo-controller configured to accept an input variable and a reference quantity, and produce an output to bring the value of the input variable towards the value of the reference quantity;

wherein

(i) said input variable is a measure of instantaneous ventilation, and

(ii) said reference quantity is a percentage of a long-term measure of ventilation continuously derived as half the absolute value of the respiratory airflow, the long-term measure of ventilation being low-pass filtered with a time constant that is long compared with the lung-chemoreceptor delay in patients with Cheyne-Stokes breathing or central sleep apnea.

2. The apparatus of claim 1, wherein said time constant is longer than the waxing-waning cycle time of untreated Cheyne-Stokes breathing or central sleep apnea.

3. The apparatus of claim 1, wherein said time constant is one hundred seconds.

4. The apparatus of claim 1 wherein said percentage of said long-term measure of ventilation is smaller than a value that will result in positive feedback and larger than one that will permit residual Cheyne-Stokes breathing.

5. The apparatus of claim 4 wherein said percentage is 95%.

6. The apparatus of claim 1 wherein said measure of instantaneous ventilation is calculated as the volume of said breathable gas inspired over a period of time less than several seconds.

7. The apparatus of claim 1 wherein said measure of instantaneous ventilation is calculated as the volume of said breathable gas expired over a period of time less than several seconds.

8. The apparatus of claim 1 wherein said measure of instantaneous ventilation is calculated as the average of the volumes of said breathable gas inspired and expired over a period of time less than several seconds.

9. The apparatus of claim 1 wherein said measure of instantaneous ventilation is calculated as half the average of the absolute value of the respiratory airflow over an interval that is short compared with several seconds.

10. The apparatus of claim 1 wherein said measure of instantaneous ventilation is calculated as half the absolute value of the respiratory airflow, the measure of instantaneous ventilation being low-pass filtered with a time constant that is short compared with several seconds.

11. The apparatus of claim 1 wherein said servo-controller is further operable to clip the degree of ventilatory support provided by the breathable gas delivered to the subject'"'"'s airway to prevent the degree of ventilatory support provided thereby from falling below a minimum degree of support, said minimum degree of support being sufficient to perform some of the respiratory work of the subject but being less than the ventilatory support that is required to perform all of the respiratory work of the subject.

12. The apparatus claim 1 wherein said servo-controller is further operable to clip the degree of ventilatory support provided by the breathable gas delivered to the subject'"'"'s airway to prevent the degree of ventilatory support provided thereby from exceeding a maximum degree of support, said maximum degree of support being sufficient to perform most or all of the subject'"'"'s work of breathing, but not being sufficient to be dangerous.

13. The apparatus of claim 1 wherein said servo-controller is further operable to modulate the breathable gas delivered to the subject'"'"'s airway in phase with the subject'"'"'s respiratory air flow when the subject is breathing adequately, and to modulate the breathable gas delivered to the subject'"'"'s airway at a preset rate when the subject is not breathing adequately.

14. A method of calculating a control signal, based on an obtained measure of a subject'"'"'s respiratory airflow, said signal being suitable for controlling the delivery of breathable gas at positive pressure to the subject'"'"'s airway in the treatment of cardiac failure, Cheyne-Stokes breathing or central sleep apnea, said method comprising:

a servo-control procedure accepting an input variable and a reference quantity, and producing said control signal as an output of the servo-control procedure, wherein the output is suitable for bringing the value of the input variable towards the value of the reference quantity;

wherein

(i) said input variable is an obtained measure of instantaneous ventilation of the subject, and

(ii) said reference quantity is a percentage of a long-term measure of ventilation continuously derived as half the absolute value of the respiratory airflow, the long-term measure of ventilation being low-pass filtered with a time constant that is long compared with the lung-chemoreceptor delay in patients with Cheyne-Stokes breathing or central sleep apnea.