Monitoring projections along principal components of multiple sensors as an indicator of worsening heart failure
First Claim
1. An implantable or other ambulatory apparatus comprising:
- at least a first physiologic sensor circuit, configured to provide a first physiologic signal and a second physiologic sensor circuit configured to provide a second physiologic signal, wherein the first and second physiologic signals include physiological information of a subject;
a processor circuit, communicatively coupled to the first and second physiologic sensor circuits, wherein the processor circuit includes a principal component analysis (PCA) circuit configured to;
represent data determined from the at least first and second physiologic sensor circuits as at least first and second axes, respectively, in a multidimensional space;
determine one or more principal components in the multidimensional space;
determine a quantitative attribute of the first and the second physiologic signals using at least one of the determined principal components or a projection of the data along the at least one determined principal component; and
provide an indication of heart failure (HF) status according to the quantitative attribute to at least one of a user or a process.
1 Assignment
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Accused Products
Abstract
A device can include at least a first physiologic sensor circuit configured to provide a first physiologic signal, a second physiologic sensor circuit configured to provide a second physiologic signal, and a processor circuit. The processor circuit includes a principal component analysis circuit configured to represent data determined from the at least first and second physiologic sensor circuits as at least first and second axes, respectively, in a multidimensional space, determine one or more principal components in the multidimensional space, determine a quantitative attribute of the first and the second physiologic signals using at least one of the determined principal components or a projection of the data along the at least one determined principal component, and provide an indication of heart failure status according to the quantitative attribute to at least one of a user or a process.
36 Citations
20 Claims
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1. An implantable or other ambulatory apparatus comprising:
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at least a first physiologic sensor circuit, configured to provide a first physiologic signal and a second physiologic sensor circuit configured to provide a second physiologic signal, wherein the first and second physiologic signals include physiological information of a subject; a processor circuit, communicatively coupled to the first and second physiologic sensor circuits, wherein the processor circuit includes a principal component analysis (PCA) circuit configured to; represent data determined from the at least first and second physiologic sensor circuits as at least first and second axes, respectively, in a multidimensional space; determine one or more principal components in the multidimensional space; determine a quantitative attribute of the first and the second physiologic signals using at least one of the determined principal components or a projection of the data along the at least one determined principal component; and provide an indication of heart failure (HF) status according to the quantitative attribute to at least one of a user or a process. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of operating an implantable or other ambulatory medical device, the method comprising:
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sensing at least a first physiologic signal using a first physiologic sensor circuit and a second physiologic signal using a second physiologic sensor circuit, wherein the first and second physiologic signals include physiological information of a subject; representing, using a processor circuit including a principal component analysis (PCA) circuit, data determined from the at least first physiologic signal and second physiologic signal as at least a first and a second axis, respectively, in a multidimensional space; determining, using the processor circuit, one or more principal components of the data represented in the multidimensional space; determining, using the processor circuit, a quantitative attribute of the data form the first and second physiologic signals using a least one of the one or more determined principal components or a projection of the data along the at least one determined principal component; and providing, using the processor circuit, an indication of heart failure (HF) status to at least one of a user of a process according to the quantitative attribute. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification