Arthroscopic harvesting and therapeutic application of bone marrow aspirate

• US 8,858,560 B2
• Filed: 08/23/2007
• Issued: 10/14/2014
• Est. Priority Date: 08/23/2006
• Status: Active Grant

• Current Assignee: Arthrex Incorporated
• Original Assignee: Arthrex Incorporated
• Inventors: Bradley, James P., Schmieding, Reinhold, Willobee, Ashley, Teets, J. Maxwell
• Primary Examiner(s): Woodall, Nicholas
• Assistant Examiner(s): NELSON, CHRISTINE L
• Application Number:
  US11/892,495
• Publication Number:
  US 20080221527A1
• Time in Patent Office: 2,609 Days
• Field of Search: 606/86.R, 606/95, 606/232
• US Class Current: 606/86.R
• CPC Class Codes: A61B 10/025 for taking bone, bone marrow or cartilage samples
• CPC Class Codes: A61B 17/3472 for bones, e.g. intraosseus injections
• CPC Class Codes: A61B 2010/0258 Marrow samples
• CPC Class Codes: A61F 2/4601 for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/4649 Bone graft or bone dowel harvest sites
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/48 with macromolecular fillers
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin

Abstract

Methods of arthroscopic harvesting of bone marrow aspirate from bone joints and therapeutic application of the bone marrow aspirate in a bone joint. The method of harvesting includes extracting bone marrow from a joint, adding a biomaterial, and adding clotting agent to form a clot.

Claims

1. A method of harvesting and therapeutic application of bone marrow aspirate, comprising:

establishing a portal proximal to a human joint using a trocar;

inserting an aspiration needle through the portal into the joint and into a surgical site of a bone of the joint and, subsequently, removing the trocar;

connecting a first syringe to the aspiration needle and, subsequently, aspirating bone marrow from the surgical site of the bone of the human joint using the first syringe;

transferring the bone marrow into a tray containing a biomaterial to hydrate the biomaterial with the bone marrow and to obtain a hydrated biomaterial;

applying the hydrated biomaterial with the bone marrow to the same surgical site of the same human joint through an arthroscopic procedure; and

securing the hydrated biomaterial with the bone marrow at the human joint by placing suture over the hydrated material with the bone marrow, and securing the suture with fixation devices to the bone,

wherein the steps of aspirating and applying bone marrow from and to the same surgical site of the human joint are conducted arthroscopically.

2. The method of claim 1, wherein the biomaterial comprises collagen.

3. The method of claim 1, wherein the human joint comprises one of a shoulder joint, a hip joint, an elbow joint, and a knee joint.

4. The method of claim 1, wherein the biomaterial is a patch and wherein the method further comprises the steps of hydrating the patch with the bone marrow to obtain a bone marrow aspirate patch and delivering the patch to an injured tissue.

5. The method of claim 4, wherein the step of delivering the patch further comprising:

passing the suture through a lateral cannula and through a rotator cuff of a shoulder joint, the suture having the patch on one end and a button on another end;

pulling the suture to place the patch under a tissue; and

pulling the button through the lateral cannula and subsequently, securing the suture in a criss-cross arrangement using knotless fixation devices and suture anchors.

6. The method of claim 1, further comprising the step of adding a clotting agent to the bone marrow to form a clot subsequent to the step of transferring the bone marrow into a tray.

7. The method of claim 6, wherein the clotting agent comprises calcium salt comprising calcium chloride solution having a concentration of about 10%.

8. The method of claim 6, wherein the clotting agent comprises thrombin solution having a concentration of 1000 I.U./ml.