Frozen compositions and methods for piercing a substrate
First Claim
Patent Images
1. A fluidic device, comprising:
- a support structure at least partially defining at least one compartment; and
at least one frozen fluid piercing implement including at least one therapeutic agent, the frozen fluid piercing implement in fluid communication with the at least one compartment wherein at least one first implement is configured to deliver at least one agent, and at least one second implement is configured to sense or extract at least one material from the at least one substrate.
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Abstract
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
263 Citations
21 Claims
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1. A fluidic device, comprising:
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a support structure at least partially defining at least one compartment; and at least one frozen fluid piercing implement including at least one therapeutic agent, the frozen fluid piercing implement in fluid communication with the at least one compartment wherein at least one first implement is configured to deliver at least one agent, and at least one second implement is configured to sense or extract at least one material from the at least one substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 20, 21)
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9. A fluidic device, comprising:
at least one frozen fluid piercing implement including at least one therapeutic agent, and at least one actuator configured to actuate the at least one frozen fluid piercing implement into at least one biological tissue, wherein the at least one frozen piercing implement is configured to sense or extract at least one material from at least one substrate, and further including at least one compartment configured to hold at least one material extracted from at least one substrate. - View Dependent Claims (10, 11, 12)
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13. A fluidic device, comprising:
at least one frozen fluid piercing implement including at least one therapeutic agent, and at least one actuator configured to actuate the at least one frozen fluid piercing implement into at least one biological tissue, wherein the at least one actuator includes at least one microactuator or nanoactuator. - View Dependent Claims (14, 15, 16, 17, 18)
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19. A fluidic device, comprising:
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at least one frozen fluid piercing implement including at least one therapeutic agent, and at least one actuator configured to actuate the at least one frozen fluid piercing implement into at least one biological tissue, further including a plurality of frozen piercing implements, and at least one actuator configured to actuate the plurality of frozen piercing implements; wherein each piercing implement has at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer, or any value therebetween.
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Specification