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Micelle encapsulation of a combination of therapeutic agents

  • US 8,858,965 B2
  • Filed: 08/30/2013
  • Issued: 10/14/2014
  • Est. Priority Date: 09/25/2009
  • Status: Active Grant
First Claim
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1. A composition comprising micelles encapsulating three drugs, whereinthe three drugs are non-covalently encapsulated in the interior of the micelles;

  • the micelles comprise poly(ethylene glycol)-block-poly(lactic acid) polymers where the hydrophobic poly(lactic acid) block of the polymers orient toward the interior of each micelle, and the hydrophilic poly(ethylene glycol) block of the polymers orient toward the exterior of each micelle;

    a first drug of the three drugs encapsulated in the micelles is 17-AAG or 17-DMAG;

    a second drug of the three drugs encapsulated in the micelles is paclitaxel or docetaxel; and

    a third drug of the three drugs encapsulated in the micelles is rapamycin, deforolimus, temsirolimus, everolimus, etoposide, or teniposide.

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