Assessing the condition of a joint and preventing damage

• US 8,862,202 B2
• Filed: 09/10/2012
• Issued: 10/14/2014
• Est. Priority Date: 09/14/1998
• Status: Expired due to Term

• Current Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Original Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Inventors: Alexander, Eugene J., Andriacchi, Thomas P., Lang, Philipp, Napel, Sandy A.
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): Foreman, Jonathan M
• Application Number:
  US13/608,766
• Publication Number:
  US 20130006598A1
• Time in Patent Office: 764 Days
• Field of Search: 600/410, 600/411, 600/425, 600/427, 600/439, 600/587, 600/595, 703/11
• US Class Current: 600/410
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/1114 Tracking parts of the body
• CPC Class Codes: A61B 5/112 Gait analysis
• CPC Class Codes: A61B 5/1121 Determining geometric values, e.g. centre of rotation or angular range of movement
• CPC Class Codes: A61B 5/1127 using markers
• CPC Class Codes: A61B 5/4514 Cartilage
• CPC Class Codes: A61B 5/4528 Joints A61B5/4533, A61B5/4538 take precedence
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor

Abstract

Methods are disclosed for assessing the condition of a cartilage in a joint, particularly a human knee. The methods include converting an image such as an MRI to a three dimensional map of the cartilage. The cartilage map can be correlated to a movement pattern of the joint to assess the affect of movement on cartilage wear. Changes in the thickness of cartilage over time can be determined so that therapies can be provided. Information on thickness of cartilage and curvature of cartilage or subchondral bone can be used to plan therapy. Information on movement pattern can be used to plan therapy.

Claims

1. A method of generating a biomechanical model using a computer system for providing a therapy of a patient'"'"'s joint, the method comprising:

accessing a reference database of biomechanical data associated with one or more joints of one or more subjects;

selecting biomechanical data from the reference database based on one or more individual characteristics of the patient;

deriving from electronic image data of the patient'"'"'s joint information comprising at least one of volume, area, thickness, shape, curvature, geometry, biochemical contents, signal intensity and relaxation time of normal and diseased articular cartilage of the patient'"'"'s joint; and

creating, in a computer system, a biomechanical model of the joint based on the information and the selected biomechanical data.

2. The method of claim 1, wherein the therapy includes an osteotomy.

3. The method of claim 1, wherein the patient'"'"'s joint is a knee joint and wherein the biomechanical model includes a contact area between the femur and the tibia of the knee joint.

4. The method of claim 1, wherein the biomechanical model includes a contact area between two compartments of the patient'"'"'s joint.

5. The method of claim 1, wherein the one or more individual characteristics are selected from the group consisting of type of joint, gender, age, height, weight, bone size, type of movement, and distance of movement.

6. The method of claim 1, wherein the therapy includes a joint replacement surgery.

7. The method of claim 1, wherein the information includes a cartilage degeneration pattern of the patient'"'"'s joint.

8. The method of claim 1, wherein the biomechanical data includes a collection of movement patterns.