Active transdermal medicament patch and circuit board for same
First Claim
1. A transdermal medicament patch comprising:
- (a) a flexible, planar biocompatible substrate having on one side thereof an upper face and on the other side thereof a therapeutic face configured for releasable retention against the skin of a patient;
(b) a circuit board carried on said upper face of said substrate, said circuit board having on one side thereof a support face and on the other side thereof an attachment face, a portion of said attachment face of said circuit board being non-removably secured to said upper face of said substrate;
(c) a printed circuit on said support face of said circuit board;
(d) a power source mounted directly on said support face of said circuit board;
(e) an electrode carried on said support face of said circuit board, said electrode being electrically coupled to said power source by said printed circuit; and
(f) an electrode hinge traversing said circuit board intermediate said electrode and said power source for permitting bending of said circuit board between;
(i) a planar state of said circuit board; and
(ii) a compact state of said circuit board, wherein a portion of said circuit board is folded over such that two portions of said circuit board are in planar contact with each other, wherein in said compact state of said circuit board, the periphery of said circuit board assumes the shape of a barbell, said barbell having enlarged ends interconnected by an intermediate portion narrower in extent than the ends.
1 Assignment
0 Petitions
Accused Products
Abstract
An active transdermal medicament patch includes a planar substrate with a therapeutic face releasably retainable against the skin of a patient. A return electrode and a medicament matrix susceptible to permeation by medicament are secured at separated locations on the therapeutic face and electrically conductively engage the skin. A detector monitors iontophoretic medicament migration into the skin. An integrator operating on the output of the detector produces a running cumulative total of the amount of medicament delivered during a plurality of temporally non-contiguous therapy subsessions. A circuit breaker terminates medicament migration, when the output of the integrator equals a predetermined medicament quantity. A timer active during medicament migration stimulates a driver to operate a light-emitting diode in a distinct delivery confirmation mode during each a sequence of non-overlapping predetermined therapy subsessions, respectively. A circuit board on the substrate in a compact, folded state bears interconnected electrical circuit components.
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Citations
31 Claims
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1. A transdermal medicament patch comprising:
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(a) a flexible, planar biocompatible substrate having on one side thereof an upper face and on the other side thereof a therapeutic face configured for releasable retention against the skin of a patient; (b) a circuit board carried on said upper face of said substrate, said circuit board having on one side thereof a support face and on the other side thereof an attachment face, a portion of said attachment face of said circuit board being non-removably secured to said upper face of said substrate; (c) a printed circuit on said support face of said circuit board; (d) a power source mounted directly on said support face of said circuit board; (e) an electrode carried on said support face of said circuit board, said electrode being electrically coupled to said power source by said printed circuit; and (f) an electrode hinge traversing said circuit board intermediate said electrode and said power source for permitting bending of said circuit board between; (i) a planar state of said circuit board; and (ii) a compact state of said circuit board, wherein a portion of said circuit board is folded over such that two portions of said circuit board are in planar contact with each other, wherein in said compact state of said circuit board, the periphery of said circuit board assumes the shape of a barbell, said barbell having enlarged ends interconnected by an intermediate portion narrower in extent than the ends. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A transdermal medicament patch comprising:
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(a) a flexible, planar biocompatible substrate having on one side thereof an upper face and on the other side thereof a therapeutic face configured for releasable retention against the skin of a patient; (b) a circuit board carried on said upper face of said substrate, said circuit board having on one side thereof a support face and on the other side thereof an attachment face, a portion of said attachment face of said circuit board being non-removably secured to said upper face of said substrate; (c) a printed circuit on said support face of said circuit board; (d) a power source carried on said support face of said circuit board; (e) an active electrode carried on said support face in a first region of said circuit board, said active electrode being electrically coupled to said power source by said printed circuit; (f) a return electrode carried on said support face in a second region of said circuit board nonadjacent to said first region thereof, said active electrode being electrically coupled to said power source by said printed circuit; and (g) an electrode flexion network traversing said circuit board intermediate said active electrode and said power source and between said return electrode and said power source, said electrode flexion network permitting said circuit board to assume a planar state and a folded state, in said folded state of said circuit board portions of said attachment face in each of said first region and said second region of said circuit board engaging corresponding portions of said attachment face in a third region of said circuit board intermediate said first and second regions, and wherein in said folded state of said circuit board, the periphery of said circuit board assumes the shape of a barbell, said barbell having enlarged ends interconnected by an intermediate portion narrower in extent than the ends. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A transdermal medicament patch comprising:
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(a) a flexible, planar biocompatible substrate having on one side thereof an upper face and on the other side thereof a therapeutic face configured for releasable retention against the skin of a patient, said substrate having formed therethrough a first electrode aperture and a second electrode aperture separated therefrom; (b) a circuit board carried on said upper face of said substrate, said circuit board having on one side thereof a support face and on the other side thereof an attachment face in part non-removably secured to said upper face of said substrate, said circuit board being capable of assuming a planar state and a folded state, in said folded state of said circuit board portions of said attachment face in each of a first region and a nonadjacent second region of said circuit board engage corresponding portions of said attachment face in a third region of said circuit board intermediate said first and second regions and wherein in said folded state of said circuit board, the periphery of said circuit board assumes the shape of a barbell, said barbell having enlarged ends interconnected by an intermediate portion narrower in extent than the ends; (c) a printed circuit on said support face of said circuit board; (d) an active electrode carried on said support face in said first region of said circuit board; (e) a return electrode carried on said support face in said second region of said circuit board; and (f) a power source mounted directly on said support face of said circuit board, said power source being electrically coupled to said active electrode and to said return electrode by said printed circuit. - View Dependent Claims (28, 29, 30, 31)
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Specification