Automated medical liquid filling system and method

• US 8,863,788 B2
• Filed: 01/10/2013
• Issued: 10/21/2014
• Est. Priority Date: 12/02/2005
• Status: Active Grant

• Current Assignee: Baxter Corporation Englewood (Baxter International Inc.)
• Original Assignee: Baxter Corporation Englewood (Baxter International Inc.)
• Inventors: Ranalletta, Joseph Vincent, Hutchins, Loren Havener, Aumiller, Joshua Nathan
• Primary Examiner(s): Arnett, Nicholas A
• Application Number:
  US13/738,845
• Publication Number:
  US 20130192719A1
• Time in Patent Office: 649 Days
• Field of Search: 141/2, 141/18, 141 25- 27, 141/95, 141/104, 141/318, 604/407
• US Class Current: 141/25
• CPC Class Codes: A61J 1/20 Arrangements for transferring or mixing fluids, e.g. from vial to syringe
• CPC Class Codes: A61J 1/2065 having aligning and guiding means
• CPC Class Codes: A61M 2005/3114 Filling or refilling
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: A61M 2209/045 for filling, e.g. for filling reservoirs
• CPC Class Codes: B65B 3/003 Filling medical containers such as ampoules, vials, syringes or the like

Abstract

A medical liquid filling system and associated methods are provided, the system comprising a disposable and a drive system. The disposable includes a tubular member and a piston slidably disposed within the tubular member for retraction and advancement within at least a first portion of the tubular member. The disposable may include a seal member for sealing the first portion of the tubular member and may be interconnected to the piston for co-movement therewith. The drive system may include a piston drive member selectively interconnectable to the piston for driven advancement and retraction of the piston within the tubular member. The drive system may be interconnected to a controller, which may be operable to automate or semi-automate various filling operations. A user interface may be interconnected to the controller for providing input of various system operation parameters, which may be communicated to the controller to facilitate automated or semi-automated operation of the filling system.

Claims

1. A disposable for use in a system for automated filling of at least one interconnectable receptacle with a medical liquid, said system including an automated drive system with a valve drive member having one of a complimentary projection and a receiving member, comprising:

a housing comprising a tubular member and a valve housing;

a piston slidably disposed in said tubular member for retraction and advancement within at least a first portion of said tubular member;

a valve disposed within said valve housing and fluidly interconnected to said tubular member proximal to said piston, wherein said valve includes a valve stem slidably disposed within said valve housing and comprising the other of said complimentary projection and receiving member, wherein said other of said complimentary projection and receiving member is selectively connectable to and disconnectable from said one of said complimentary projection and receiving member, and wherein said other of said complimentary projection and receiving member is operable for automated positioning by said one of said complimentary projection and receiving member in at least a first valve position and a second valve position when said other of said complimentary projection and receiving member is connected to said one of said complimentary projection and receiving member; and

a plurality of ports,

wherein in said first valve position a first valve port is fluidly interconnected to said tubular member, and

wherein in said second valve position a second valve port is fluidly interconnected to said tubular member.

2. A disposable as recited in claim 1, further comprising:

a seal member for sealing a distal end of said first portion of said tubular member wherein said seal member is interconnected to said piston for co-movement therewith and slidable engagement within a second portion of said tubular member, said second portion being located distal to said first portion.

3. A disposable as recited in claim 2, wherein said first and second portions of said tubular member are each cylindrical and have first and second diameters, respectively, and wherein said second diameter is greater than said first diameter.

4. A disposable as recited in claim 2, wherein said seal member is spaced from said piston by a fixed distance that is at least as great as a length of said first portion of said tubular member.

5. A disposable as recited in claim 2, wherein said piston is positionable to at least a first piston position and to a second piston position within said tubular member, wherein said piston comprises:

a piston resilient member, wherein in said first piston position said piston resilient member is positioned within and sealably engages said first portion of said tubular member.

6. A disposable as recited in claim 5, wherein in said first piston position said piston resilient member is compressed to a first degree of compression, wherein in said second piston position said resilient member is compressed to a second degree of compression, wherein said first degree of compression is greater than said second degree of compression.

7. A disposable as recited in claim 2, wherein said piston is positionable to at least a first piston position and to a second piston position within said tubular member, wherein in said first piston position at least a portion of said piston is positioned within said first portion of said tubular member and at least a portion of said seal member is positioned within said second portion of said tubular member.

8. A disposable as recited in claim 2, wherein said piston is positionable to at least a first piston position and to a second piston position within said tubular member, wherein said tubular member further comprises:

a third portion located distal to said second portion, wherein said second and third portions are each cylindrical and have second and third diameters, respectively, and wherein said third diameter is greater than said second diameter.

9. A disposable as recited in claim 8, wherein said seal member comprises:

a seal resilient member, wherein in said first piston position said seal resilient member is compressably positioned within and sealably engages said second portion of said tubular member, wherein in said first piston position said seal resilient member is compressed to a first degree of compression, wherein in said second piston position said resilient member is compressed to a second degree of compression, wherein said first degree of compression is greater than said second degree of compression.

10. A disposable as recited in claim 2, further comprising:

a first connection member interconnected to said seal member.

11. A disposable as recited in claim 10, wherein said first connection member comprises:

a male connection member including a bulbous end portion.

12. A disposable as recited in claim 10, wherein said first connection member comprises:

a female connection member.

13. A disposable as recited in claim 12, wherein said female connection member comprises:

a plurality of fingers.

14. A disposable as recited in claim 13, wherein said plurality of fingers compress when located within said second portion of said tubular member.

15. A disposable as recited in claim 1, wherein said valve stem is rotatably disposed within said valve housing for automated rotative positioning by said one of said complimentary projection and receiving member when said other of said complimentary projection and receiving member is connected to said one of said complimentary projection and receiving member.

16. A disposable as recited in claim 15, said valve stem including:

at least first and second channels, wherein said first channel fluidly connects said first valve port and said tubular member only when said valve is in said first valve position, and wherein said second channel fluidly interconnects said second valve port and said tubular member only when said valve is in a said second valve position.

17. A disposable as recited in claim 16, wherein said valve stem comprises:

a stop portion, wherein in a third valve position said stop portion restricts fluid communication between said first port and said tubular member and between said second valve port and said tubular member.

18. A disposable as recited in claim 16, wherein said first and second channels comprise arcuate paths disposed about a perimeter of said valve stem and wherein said valve stem perimeter is defined in part by said first and second channels.

19. A disposable as recited in claim 1, said disposable further comprising:

a first fluid line interconnected at one end to said first valve port and interconnectable at another end to at least a first medical liquid source; and

a second fluid line interconnected at one end to said second valve port and interconnectable at another end to at least one vessel, wherein said disposable is operative to pump a medical liquid through said first fluid line, said tubular member, and said second fluid line free from occlusion of said first and second fluid lines.

20. A disposable as recited in claim 1, wherein said tubular member is substantially non-deformable.

21. A disposable as recited in claim 1, wherein the piston includes an end nipple and the tubular member includes a corresponding nozzle portion for receiving said end nipple.

22. A disposable as recited in claim 21, wherein the end nipple and the nozzle portion comprise corresponding conformal shapes.

23. A disposable as recited in claim 22, wherein the end nipple and the nozzle portion comprise corresponding lengths.

24. A disposable as recited in claim 21, wherein the piston is positionable to position the end nipple within the nozzle portion.

25. A disposable as recited in claim 1, wherein said other of said complimentary projection and receiving member is operable for rotatable driven positioning.

26. A disposable as recited in claim 1, wherein said one of said complimentary projection and receiving member comprises a male connection, wherein said other of said complementary projection and receiving member comprises a female connection, and wherein said female member is integrally defined by said valve stem.