Eye covering and refractive correction methods and apparatus having improved tear flow, comfort, and/or applicability

• US 8,864,306 B2
• Filed: 04/25/2012
• Issued: 10/21/2014
• Est. Priority Date: 04/28/2011
• Status: Active Grant

• Current Assignee: Journey1, Inc.
• Original Assignee: Nexisvision, Inc.
• Inventors: de Juan, Eugene Jr., Reich, Cary J., Alster, Yair, Tuan, Kunagmon Ashley, Levy, Brian, Clark, Matt
• Primary Examiner(s): Mack, Ricky
• Assistant Examiner(s): ALEXANDER, WILLIAM R
• Application Number:
  US13/456,168
• Publication Number:
  US 20130077044A1
• Time in Patent Office: 909 Days
• Field of Search: 351/159.04, 351/159.1, 351/159.12, 351/159.14, 351/159.18, 351/159.19, 351/159.22, 351/159.36, 351/159.78, 623 512- 515
• US Class Current: 351/159.04
• CPC Class Codes: G02C 7/022 Ophthalmic lenses having special refractive features achieved by special materials or material structures G02C7/049 takes precedence
• CPC Class Codes: G02C 7/024 Methods of designing ophthalmic lenses
• CPC Class Codes: G02C 7/04 Contact lenses for the eyes disinfection or sterilisation of contact lenses A61L12/00
• CPC Class Codes: G02C 7/047 Contact lens fitting; Contact lenses for orthokeratology; Contact lenses for specially shaped corneae
• CPC Class Codes: G02C 7/049 Contact lenses having special fitting or structural features achieved by special materials or material structures

Abstract

An eye covering such as a contact lens may comprise one or more structures to pump tear liquid under the covering such that the covering can remain in the eye and correct vision for an extended amount of time. In many embodiments, the covering comprises a material having fenestrations to draw tear liquid under the covering and an outer portion shaped to contact the conjunctiva over the sclera, such that when the eye closes pressure of one or more eyelids urges tear liquid through one or more fenestrations and under the outer portion shaped to contact the conjunctiva. When the eye blinks, the pressure of the one or more eyelids can urge the covering toward the cornea such that tear liquid can pass through the fenestrations.

Claims

1. A covering to treat an eye of a patient, the eye having a tear liquid, a pupil, a cornea, and a conjunctiva, the covering comprising:

an optical component to correct vision of the eye, the optical component comprising a first rigidity sufficient to resist deformation when placed on the eye and a posterior surface extending along the inner optic portion and configured so that engagement of the posterior surface against the eye deforms the posterior surface of the lens and so that the posterior surface extending along the inner optic portion has a shape diverging from the refractive shape of the cornea and defines at least one lenticular volume;

a coupling component to contact the cornea and the conjunctiva and to support the optical component in relation to the pupil, the coupling component comprising an outer portion sized to contact the conjunctiva, an inner portion to couple to the optical component, and an intermediate portion extending between the inner portion and the outer portion, one or more of the optical component or the coupling component comprising a plurality of fenestrations coupled to the at least one lenticular volume to pump the tear liquid when the eye blinks.

2. The covering of claim 1 wherein the covering comprises an inner portion comprising the optical component and the inner portion of the coupling component and wherein an outer portion of the covering comprises the intermediate portion of the coupling component and the outer portion of the coupling component.

3. The covering of claim 1 wherein eye comprises eyelids and the intermediate portion corresponds to an outer location of the cornea and wherein the intermediate portion comprises a resistance to deflection sufficient to form a chamber having a volume when the covering is placed on the eye with the eyelids separated and wherein the resistance to deflection allows the covering to deflect toward the cornea to decrease the volume of the chamber and pump the tear liquid when one or more of the eyelids contacts the intermediate portion.

4. The covering of claim 3 wherein the cornea comprises an inner portion and an outer portion and wherein the inner portion of the coupling component comprises a lower surface having a curvature corresponding to a curvature of an upper surface of the inner portion of the cornea and wherein the intermediate portion of the coupling component comprises a lower surface having a curvature no more than an upper surface of the outer portion of the cornea such that the intermediate portion of the coupling component is located over the outer portion of the cornea and the outer portion of the coupling component extends to the conjunctiva so as to define the chamber when the covering is placed on the eye.

5. The covering of claim 4 wherein the eye comprises a limbus and wherein the outer portion of the coupling component comprises a second resistance to deflection sufficient to form the chamber with the gap when the outer portion contacts the conjunctiva and the inner portion of the coupling component contacts the inner portion of the cornea.

6. The covering of claim 1 wherein the coupling component comprises a deflectable material that inhibits passage of the tear liquid through the material such that the tear liquid passes through the fenestrations when the eye blinks and an eyelid exerts pressure on the optical component.

7. The covering of claim 5 wherein the coupling component comprises a first configuration when the eyelid is away from the optical component and a second configuration when the eyelid exerts pressure on the optical component and wherein the deflectable material of the coupling component comprises an elastically deformable material that conforms elastically to at least a portion of the eye when the eye blinks and wherein the coupling component returns to the first configuration when the eyelid has moved away from the optical component.

8. The covering of claim 6 wherein the optical component comprises a first rigidity and the coupling component comprises a second rigidity less than the first rigidity and wherein the optical component comprises a substantial surface area such that pressure of an eyelid on a portion of the first component provides volumetric pumping of the tear liquid through the fenestrations when the eye blinks and deflects the second component.

9. The covering of claim 8 wherein the deflectable material of the second component defines a chamber with the cornea and conjunctiva and allows the first component to move downward on the cornea with pressure of the eyelid so as to decrease a volume of the chamber and displace tear liquid with flow outwardly through the fenestrations when the outer portion contacts the conjunctiva.

10. The covering of claim 9 wherein the deflectable material of the second component allows the first component to move away from on the cornea with decreased pressure of the eyelid so as to increase the volume of the chamber and displace tear liquid with flow inwardly through the fenestrations when the outer portion contacts the conjunctiva.

11. The covering of claim 8 wherein the outer portion comprises a third rigidity less than the first rigidity and the second rigidity such that the third portion contacts the conjunctiva and stretches elastically to move the optical component toward the cornea and pump tear liquid outwardly through the fenestrations when the eye blinks and an eye lid exerts downward pressure on the optical component and wherein the elastically stretched outer portion moves the optical component away from the cornea and pumps tear liquid inwardly through the fenestrations with flow when the eye blinks and exerts downward pressure on the optical component.

12. The covering of claim 8 wherein the optical component comprises a maximum dimension across of at least about 5 mm corresponding to the substantial surface area, the substantial surface area comprising at least about 15 mm2.

13. The covering of claim 8 wherein the first rigidity comprises a relative rigidity within a range from about 3.5E-5 to about 6E-4 Pa*m^3 and the second rigidity comprises a relative rigidity within a range from about 2.5E-6 to about 3E-4.

14. The covering of claim 1 wherein the inner portion, the outer portion and the peripheral portion are sized and curved such that the peripheral portion couples to the conjunctiva to inhibit sliding movement of the optical component along the cornea and to inhibit tear flow at locations where the outer portion couples the conjunctiva when the eye blinks.

15. The covering of claim 14 wherein the outer portion comprises an elastic material and a lower surface to contact the conjunctiva, the lower surface corresponding to a radius of curvature no more than a radius of curvature of the conjunctiva such that the outer portion stretches so as to conform to the conjunctiva and form a seal with the conjunctiva when the eye blinks.

16. The covering of claim 15 wherein a lower surface of the intermediate portion comprises a first slope angle and a first curvature where the intermediate portion meets the outer portion and wherein the lower surface of the outer portion comprises a second slope angle and a second curvature where the outer portion meets the intermediate portion, the first curvature greater than the second curvature, and wherein the second slope angle is aligned with the first slope angle to inhibit ridge formation along a boundary where the outer portion meets the intermediate portion.

17. The covering of claim 15 wherein the lower surface comprises a first non-stretched radius of curvature of no more than about 12 mm such that the radius of curvature of the lower surface increases from the first non-stretched curvature to a second stretched curvature corresponding to the radius of curvature of the conjunctiva when the lower surface of the outer portion contacts the conjunctiva.

18. The covering of claim 1 wherein the covering comprises a contact lens and wherein the optical component comprises a lower surface and an upper surface, the lower surface having first curvature corresponding to a curvature of the cornea, the upper surface comprising a surface elevation profile corresponding to an optical correction of the eye and wherein the optical component is attached to the coupling component.

19. The covering of claim 18 wherein the surface elevation profile and the optical correction correspond to correction of one or more of spherical refractive error, astigmatic refractive error, spherical aberration correction, wavefront aberration correction, a bifocal correction, a myopia prevention correction, a bifocal correction to inhibit progression of myopia, an aberration correction to inhibit progression of myopia, or presbyopia correction.

20. The covering of claim 1 wherein the intermediate portion comprises a lower surface having a plurality of curvatures.

21. The covering of claim 20 wherein the plurality of curvatures comprises a first curvature having a first radius of curvature and a second curvature having a second radius of curvature.

22. The covering of claim 21 wherein the intermediate portion comprises an inner intermediate portion having the first radius of curvature and a second intermediate portion having the second radius of curvature, the first radius of curvature less than the second radius of curvature, wherein the first intermediate portion comprises a first slope angle proximate to the second intermediate portion and the second intermediate portion comprises a second slope angle proximate to the first intermediate portion and wherein the first slope angle is aligned with the second slope angle to inhibit ridge formation along a boundary where the first intermediate portion meets the second intermediate portion.

23. The covering of claim 20 wherein the plurality of curvatures of the intermediate portion corresponds to curvatures of an aspheric surface having a conic constant and wherein the conic constant corresponds to a first radius of curvature at a first radial location away from a center of the optical component and a second radius of curvature at a second radial location away from the center of the optical component.

24. The covering of claim 1 wherein the inner portion of the coupling component extends along a lower surface of the optical component such that the optical component is supported on the cornea and aligned relative to the pupil the inner portion of the coupling component extending between the optical component and the cornea.

25. The covering of claim 1 wherein at least an upper surface of the covering is coated with one or more of a plasma coating, a chemical vapor deposition, or a luminous chemical vapor deposition.

26. The covering of claim 1 wherein the plurality of fenestrations is located away from the optical component to pump tear liquid under the optical component.

27. The covering of claim 1 wherein the plurality of fenestrations is located away from the optical component to inhibit optical effects of the plurality of fenestrations.

28. The covering of claim 1 wherein the optical component comprises a first center and the coupling component comprises a second center and wherein the first center is located away from the second center to align the optical component with the pupil when the coupling component is coupled to the conjunctiva and aligned with an axis of the eye.

29. The covering of claim 1 wherein the covering comprises an extended wear covering capable of being safely worn continuously on the eye without removal for at least about seven days.

30. A covering to treat an eye of a patient, the covering comprising:

an optical component to correct vision of the eye, the optical component comprising a first rigidity sufficient to resist deformation when placed on the eye and a posterior surface extending along the inner optic portion and configured so that engagement of the posterior surface against the eye deforms the posterior surface of the lens and so that the posterior surface extending along the inner optic portion has a shape diverging from the refractive shape of the cornea and defines at least one lenticular volume;

a coupling component to contact the cornea and the conjunctiva and support the optical component in relation to the pupil, the coupling component comprising a water inhibiting layer having a plurality of fenestrations coupled to the at least one lenticular volume and extending from an anterior surface of the covering to a hydrogel layer.

31. The apparatus of claim 30 wherein the fenestrations extend through the hydrogel layer to pump tear liquid.

32. The apparatus of claim 30 wherein the hydrogel layer extending along the posterior surface covers a posterior end of the fenestrations.

33. A covering to treat an eye of a patient, the eye having a tear liquid, a pupil, a cornea, and a conjunctiva, the covering comprising:

an optical component to correct vision of the eye, the optical component comprising a first rigidity sufficient to resist deformation when placed on the eye and a posterior surface extending along the inner optic portion and configured so that engagement of the posterior surface against the eye deforms the posterior surface of the lens and so that the posterior surface extending along the inner optic portion has a shape diverging from the refractive shape of the cornea and defines at least one lenticular volume;

a coupling component to contact the cornea and the conjunctiva and support the optical component in relation to the pupil, the coupling component comprising a layer of hydrogel extending along a posterior surface of the covering, the coupling component comprising an outer portion sized to contact the conjunctiva, an inner portion to couple to the optical component, and an intermediate portion extending between the inner portion and the outer portion, one or more of the optical component or the coupling component comprising a plurality of fenestrations coupled to the at least one lenticular volume and coupled to the hydrogel layer.

34. A set of alternatively selectable ophthalmic lens for correcting refractive errors of eyes of a population of patients, each eye having a cornea with an epithelium providing a refractive shape, the set comprising:

a plurality of alternative ophthalmic lenses having differing spherical powers, each ophthalmic lens having;

an anterior surface corresponding to an associated desired spherical power, the anterior surface extending along an inner portion of the ophthalmic lens, wherein the inner portion of the ophthalmic lens is deformable; and

a peripheral portion of the ophthalmic lens extending radially outwardly from the inner portion, the peripheral portion having a rigidity lower than that of the inner portion and configured for engaging tissue outside the optical region so as to support the inner portion in alignment with an optical region;

a posterior surface extending along the inner portion, the posterior surface a surface of the cornea defining at least one lenticular volume; and

a plurality of fenestrations through a thickness of the ophthalmic lens and configured to induce flow of tear fluid through the plurality of fenestrations when the eye blinks.

35. A ophthalmic lens for treating presbyopia of an eye of a patient, the eye having a cornea with an epithelium providing a refractive shape, the ophthalmic lens comprising:

an inner portion configured to be disposed over the optical region of the cornea, wherein the inner portion of the ophthalmic lens is deformable;

a peripheral portion having a rigidity lower than that of the inner portion and configured to support the inner portion of the ophthalmic lens by engagement between the peripheral portion and eye tissue disposed outside the optical region;

an anterior surface extending along the inner portion, the anterior surface having a presbyopia-mitigating refractive shape;

a posterior surface extending along the inner portion, the posterior surface a surface of the cornea defining at least one lenticular volume; and

a plurality of fenestrations through a thickness of the ophthalmic lens and configured to induce flow of tear fluid through the plurality of fenestrations when the eye blinks.

36. A ophthalmic lens for correcting a refractive error of an eye, the eye having a cornea with an epithelium providing a refractive shape extending across an optical region of the eye, the ophthalmic lens comprising:

an inner portion configured to be disposed over the optical region of the cornea;

a posterior surface extending along the inner portion adjacent the eye when the inner portion is disposed over the optical region, the posterior surface having a shape diverging from the refractive shape of the epithelium so that a lenticular volume is disposed therebetween;

a peripheral portion of the ophthalmic lens disposed radially outwardly of the inner portion, the peripheral portion configured to engage the eye outside the optical region so as to retain fluid filling the lenticular volume;

an anterior surface of the ophthalmic lens extending along the inner portion opposite the posterior surface so that viewing with the eye through fluid filled lenticular volume and inner portion mitigates the refractive error; and

a plurality of fenestrations through a thickness of the ophthalmic lens and configured to induce flow of tear fluid into and out of the lenticular volume when the eye blinks.