Biomimmetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement
First Claim
1. An implantable device for soft-tissue or soft tissue-to-bone fixation, repair, augmentation, or replacement comprising a biomimetic scaffold, said scaffold being biphasic and continuous from a first phase to a second phase, wherein fibers in the first phase have at least one of different alignment, different orientation, different composition and different coating as compared to fibers in the second phase, and wherein the fibers in the first phase are made from a polymer and the second phase is coupled to the first phase, the fibers in the second phase are composite fibers, each of the composite fibers of the second phase is made from a combination of a polymer and a biocompatible ceramic.
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Abstract
An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.
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Citations
50 Claims
- 1. An implantable device for soft-tissue or soft tissue-to-bone fixation, repair, augmentation, or replacement comprising a biomimetic scaffold, said scaffold being biphasic and continuous from a first phase to a second phase, wherein fibers in the first phase have at least one of different alignment, different orientation, different composition and different coating as compared to fibers in the second phase, and wherein the fibers in the first phase are made from a polymer and the second phase is coupled to the first phase, the fibers in the second phase are composite fibers, each of the composite fibers of the second phase is made from a combination of a polymer and a biocompatible ceramic.
- 21. An implantable biphasic biomimetic device for soft-tissue or soft tissue-to-bone interface fixation, repair, augmentation, or replacement, comprising a first phase comprising fibers made from a polymer and a second phase coupled to the first phase, said second phase comprising composite fibers, and each of the composite fibers of the second phase is made from a combination of a polymer and a biocompatible ceramic, wherein the first and second phases are continuous.
- 45. An implantable device for fixation, repair, augmentation, or replacement of a rotator cuff or a tendon-to bone interface thereof comprising a biphasic and biomimetic scaffold having a first phase comprising fibers whose anisotropy mimics that of a tendon and non-mineralized fibrocartilage, said fibers having been made from a polymer, and a second phase coupled to the first phase, said second phase comprising composite fibers whose anisotropy mimics that of mineralized fibrocartilage and bone, each of said composite fibers is made from a combination of a polymer and a biocompatible ceramic, wherein the first and second phases are continuous.
- 48. An implantable device for soft-tissue or soft tissue-to-bone fixation, repair, augmentation, or replacement comprising a biomimetic scaffold, said scaffold comprising at least two adjacent continuous phases, wherein a first phase includes fibers having at least one of different alignment, different orientation, different composition and different coating as compared to fibers in a second phase, wherein the first phase comprises composite fibers, each composite fiber is made from a combination of a polymer and a biocompatible ceramic, the second phase is coupled to the first phase, said second phase comprising fibers made from a polymer, and further comprising a third phase coupled to the second phase, which third phase comprises composite fibers, each composite fiber is made from a combination of a polymer and a biocompatible ceramic, wherein the first, second and third phases are continuous.
Specification