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Bioadhesive drug formulations for oral transmucosal delivery

  • US 8,865,211 B2
  • Filed: 08/27/2012
  • Issued: 10/21/2014
  • Est. Priority Date: 01/06/2006
  • Status: Active Grant
First Claim
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1. A method of treating pain in a subject, comprising administering a bioadhesive tablet to the oral mucosa of a subject,wherein said tablet comprises:

  • (a) from about 2.5 to about 100 micrograms of sufentanil, expressed as the base; and

    (b) a bioadhesive material, wherein said bioadhesive material provides for adherence to the oral mucosa of said subject, and(c) said tablet has a volume of from about 0.1 microliters to about 50 microliters,wherein after administration of said tablet to said subject, said tablet provides a minimal saliva response and minimal swallowing of sufentanil; and

    more than 50% of drug delivery of sufentanil occurs via the oral transmucosal route.

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