Medical device with predefined activated cellular integration
First Claim
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1. A medical device comprising:
- a substrate having a surface functionalized with at least one click reactive member; and
a chemotactic agent functionalized with at least one complementary click reactive member, wherein the at least one click reactive member and the at least one complementary click reactive member are covalently bonded, adhering the chemotactic agent directly to the surface of the substrate, and the surface of the substrate promotes cellular integration.
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Abstract
A medical device includes a substrate having at least a portion thereof functionalized with at least one reactive member and a chemotactic agent functionalized with at least one complementary reactive member. The at least one reactive member and the at least one complementary reactive member are covalently bonded, adhering the chemotactic agent to the substrate.
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Citations
20 Claims
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1. A medical device comprising:
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a substrate having a surface functionalized with at least one click reactive member; and a chemotactic agent functionalized with at least one complementary click reactive member, wherein the at least one click reactive member and the at least one complementary click reactive member are covalently bonded, adhering the chemotactic agent directly to the surface of the substrate, and the surface of the substrate promotes cellular integration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 18)
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12. A method of manufacturing a medical device, the method comprising:
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functionalizing a substrate to form a plurality of click reactive members of a specific binding pair attached on a surface of the substrate; functionalizing at least one chemotactic agent to form a plurality of complementary click reactive members of the specific binding pair; and contacting the substrate and the at least one chemotactic agent, wherein the plurality of click reactive members and the plurality of complementary click reactive member are covalently bonded, adhering the at least one chemotactic agent directly to the surface of the substrate, and the surface of the substrate promotes cellular integration. - View Dependent Claims (13, 14, 19)
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15. A method of manufacturing a medical device, the method comprising:
contacting a functionalized surface of a substrate with a plurality of click reactive members of a specific binding pair with at least one functionalized chemotactic agent with a plurality of complementary click reactive members of the specific binding pair, wherein the plurality of click reactive members and the plurality of complementary click reactive member are covalently bonded, adhering the at least one functionalized chemotactic agent directly to the functionalized surface of the substrate, and the surface of the substrate promotes cellular integration. - View Dependent Claims (16, 17, 20)
Specification