Method and apparatus for assessing neural activation

• US 8,868,173 B2
• Filed: 04/13/2012
• Issued: 10/21/2014
• Est. Priority Date: 04/20/2011
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Nelson, Dwight E., Agarwal, Rahul, Jensen, Steven L., Gupta, Rahul
• Primary Examiner(s): BERHANU, ETSUB D
• Application Number:
  US13/446,459
• Publication Number:
  US 20120271189A1
• Time in Patent Office: 921 Days
• Field of Search: 600/544, 600/545
• US Class Current: 600/544
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/398 Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36132 using patient feedback
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/36153 Voltage A61N1/3616 takes precedence
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 1/36175 Pulse width or duty cycle
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means

Abstract

Various embodiments concern sensing a LFP signal from one or more electrodes, measuring the amplitude of the signals over a period of time, and calculating a plurality of variance values from the amplitude, wherein each of the variance values correspond to the variance of the amplitude for a different interval of time of the period of time with respect to the other variance values. Such embodiments may further include assessing the relative level of neural activation of an area of the brain based on the variance values, wherein the area of the brain is assessed to have a relatively higher level of neural activation when the variance is relatively higher and the area of the brain is assessed to have a relatively lower level of neural activation when the variance is relatively lower.

Claims

1. A method for assessing neural activation of a brain, comprising:

sensing one or more bioelectrical signals from one or more electrodes in contact with or proximate the brain;

measuring the amplitude of the one or more bioelectrical signals over a period of time;

calculating a plurality of variance values from the amplitude of the one or more bioelectrical signals, each of the variance values of the plurality corresponding to the variance of the amplitude for a different interval of time of the period of time with respect to the other variance values of the plurality of variance values; and

assessing the relative level of neural activation of an area of the brain based on the plurality of variance values, wherein the area of the brain is assessed to have a higher level of neural activation when the variance is higher as compared to the level of neural activation when the variance is lower and wherein sensing, measuring, calculating, and assessing are each performed at least in part by control circuitry;

wherein assessing the relative level of neural activation of the area of the brain comprises estimating the functional synaptic volume of the area of the brain.

2. The method of claim 1, wherein assessing the relative level of neural activation of the area of the brain comprises comparing the plurality of variance values and determining whether the variance has increased or decreased within the period of time, wherein the level of neural activation is assessed to have increased within the period of time if the variance increased and the level of neural activation is assessed to have decreased within the period of time if the variance decreased.

3. The method of claim 1, wherein assessing the relative level of neural activation comprises:

setting one or more of a variance baseline, variance threshold, or a variance range based on at least some of the plurality of variance values; and

determining whether one or more of the variance values deviate from one or more of the variance baseline, the variance threshold, or the variance range.

4. The method of claim 1, further comprising tracking the effectiveness of a therapy based on the assessment of the relative level of neural activation of the area of the brain.

5. The method of claim 4, wherein therapy is indicated to be at least somewhat effective if the variance of the amplitude of the one or more bioelectrical signals changes relative to a baseline variance associated with a lesser amount of the therapy or no therapy.

6. The method of claim 1, further comprising titrating one or both of an electrical stimulation therapy or a drug therapy based on the assessment of the relative level of neural activation of the area of the brain.

7. The method of claim 1, further comprising tracking a brain condition based on the assessment of the relative level of neural activation of the area of the brain, wherein the brain condition is associated with one or both of an injury and a disease.

8. The method of claim 1, further comprising determining the location of the one or more electrodes in the brain based on the assessment of the relative level of neural activation of the area of the brain.

9. The method of claim 1, wherein the one or more bioelectrical signals comprise local field potential signals.

10. A system comprising:

a lead;

one or more electrodes that are on the lead and are configured to sense bioelectrical activity of a brain; and

control circuitry configured to;

sense one or more bioelectrical signals using the one or more electrodes;

measure the amplitude of the one or more bioelectrical signals over a period of time;

calculate a plurality of variance values from the amplitude of the one or more bioelectrical signals, each of the variance values of the plurality corresponding to the variance of the amplitude for a different interval of time of the period of time with respect to the other variance values of the plurality of variance values; and

assess the relative level of neural activation of an area of the brain based on the plurality of variance values, wherein the area of the brain is assessed to have a higher level of neural activation when the variance is higher as compared to the level of neural activation when the variance is lower;

wherein the control circuitry is further configured to assess the relative level of neural activation of the area of the brain by estimating the functional synaptic volume of the area of the brain.

11. The system of claim 10, wherein the control circuitry is configured to assess the relative level of neural activation of the area of the brain by comparing the plurality of variance values and determining whether the variance has increased or decreased within the period of time, wherein the level of neural activation is assessed to have increased within the period of time if the variance increased and the level of neural activation is assessed to have decreased within the period of time if the variance decreased.

12. The system of claim 10, wherein the control circuitry is configured to assess the relative level of neural activation of the area of the brain by:

setting one or more of a variance baseline, a variance threshold, or a variance range based on at least some of the plurality of variance values; and

determining whether one or more of the variance values deviate from one or more of the variance baseline, the variance threshold, or the variance range.

13. The system of claim 10, wherein the control circuitry is further configured to track the effectiveness of a therapy based on the assessment of the relative level of neural activation of the area of the brain.

14. The system of claim 13, wherein the therapy is indicated to be at least somewhat effective if the variance of the amplitude of the one or more signals changes relative to a baseline variance associated with a lesser amount of the therapy or no therapy.

15. The system of claim 10, wherein the control circuitry is further configured to titrate one or both of an electrical stimulation therapy or a drug therapy based on the assessment of the relative level of neural activation of the area of the brain.

16. The system of claim 10, wherein the control circuitry is further configured to track a brain condition based on the assessment of the relative level of neural activation of the area of the brain and provide an output on a display based on the tracking of the brain condition, wherein the brain condition is one or both of an injury and a disease.

17. The system of claim 10, wherein the control circuitry is further configured to determine the location of the one or more electrodes based on the assessment of the relative level of neural activation of the area of the brain and indicate the location on a display.

18. The system of claim 10, wherein the one or more signals comprise local field potential signals.

19. A system for assessing activation of a brain, comprising:

means for sensing one or more bioelectrical signals from a brain;

means for measuring the amplitude of the one or more bioelectrical signals over a period of time;

means for calculating a plurality of variance values from the amplitude of the one or more bioelectrical signals, each of the variance values of the plurality corresponding to the variance of the amplitude for a different interval of time of the period of time with respect to the other variance values of the plurality of variance values; and

means for assessing the relative level of neural activation of an area of the brain based on the plurality of variance values, wherein the area of the brain is assessed to have a higher level of neural activation when the variance is higher as compared to the level of neural activation when the variance is lower; and

wherein the means for assessing comprises means for assessing the relative level of neural activation of the area of the brain by estimating the functional synaptic volume of the area of the brain.