Apparatus and method for estimating stroke volume of the heart using bio-impedance techniques

• US 8,868,175 B2
• Filed: 10/17/2013
• Issued: 10/21/2014
• Est. Priority Date: 07/03/2002
• Status: Expired due to Fees

• Current Assignee: Tel Aviv University Future Technology Development L.P. (Tel Aviv University)
• Original Assignee: Tel Aviv University Future Technology Development L.P. (Tel Aviv University)
• Inventors: Arad (Abboud), Shimon
• Primary Examiner(s): DOUGHERTY, SEAN PATRICK
• Application Number:
  US14/055,915
• Publication Number:
  US 20140046205A1
• Time in Patent Office: 369 Days
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0044 for the heart
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/7289 Retrospective gating, i.e. associating measured signals or images with a physiological event after the actual measurement or image acquisition, e.g. by simultaneously recording an additional physiological signal during the measurement or image acquisition
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal

Abstract

A method of estimating stroke volume of the heart is described. In this method, the volume of the heart is estimated from electrical impedance data of the chest, at two different phases of the cardiac cycle. The stroke volume is estimated from the difference between the volumes estimated at the two phases.

Claims

1. A method of estimating stroke volume of the heart, comprising:

a) making a first set of electrical measurements of the chest, at a first phase of the cardiac cycle;

b) estimating a first volume of the heart from data of the first set of electrical measurements;

c) making a second set of electrical measurements of the chest, at a second phase of the cardiac cycle;

d) estimating a second volume of the heart from data of the second set of electrical measurements;

e) finding a difference between the first and second volumes of the heart; and

f) using the difference between the first and second volumes of the heart to estimate the stroke volume of the heart;

wherein estimating the first volume of the heart comprises generating a first impedance image of the chest from the data of the first set of electrical measurements, and estimating the second volume of the heart comprises generating a second impedance image of the chest from the data of the second set of electrical measurements, and generating the second impedance image of the chest comprises putting constraints on differences between the second impedance image and the first impedance image, but not constraining the volume of the heart to be the same in the first and second impedance images.

2. A method according to claim 1, wherein the first and second impedance images are generated using electrical data obtained using only four, five, six, seven or eight different electrodes, and not using electrical data obtained using additional electrodes.

3. A method according to claim 1, wherein generating the first and second impedance images comprises constraining the images to agree with a model for an interior region of the heart, with at least one or more geometric parameters of the interior region in the first and second images selected to provide a fit respectively to the first and second sets of electrical data.

4. A method according to claim 3, wherein the geometric parameters comprise one or more dimensions of the interior region.

5. A method according to claim 4, wherein the geometric parameters also comprise one or both of an orientation and a position of the interior region.

6. A method according to claim 4, wherein the interior region of the heart is modeled as having an elliptical cross-section, with dimensions along principal axes of the ellipse selected to provide the fit to the electrical data.

7. A method according to claim 1, wherein the first and second impedance images are two-dimensional images of a slice of the chest, and the first and second volumes of the heart are estimated from cross-sectional areas of an interior region of the heart in the first and second images.

8. A method according to claim 1, wherein the electrical data comprises at least one measurement of voltage between a pair of electrodes, while current is passed between other electrodes.