System and method for evaluating mechanical cardiac dyssynchrony based on multiple impedance vectors using an implantable medical device

• US 8,868,184 B2
• Filed: 09/02/2011
• Issued: 10/21/2014
• Est. Priority Date: 11/13/2008
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Cholette, Martin
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): VOORHEES, CATHERINE M
• Application Number:
  US13/224,606
• Publication Number:
  US 20120010516A1
• Time in Patent Office: 1,145 Days
• Field of Search: 607 7- 9, 607/17, 607 27- 28, 600/509, 600515-519, 600/547
• US Class Current: 607/17
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

A set of cardiogenic impedance signals are detected along different sensing vectors passing through the heart of the patient, particularly vectors passing through the ventricular myocardium. A measure of mechanical dyssynchrony is detected based on differences, if any, among the cardiogenic impedance signals detected along the different vectors. In particular, differences in peak magnitude delay times, peak velocity delay times, peak magnitudes, and waveform integrals of the cardiogenic impedance signals are quantified and compared to detect abnormally contracting segments, if any, within the heart of the patient. Warnings are generated upon detection of any significant increase in mechanical dyssynchrony. Diagnostic information is recorded for clinical review. Pacing therapies such as cardiac resynchronization therapy (CRT) can be activated or controlled in response to mechanical dyssynchrony to improve the hemodynamic output of the heart.

Claims

1. A method for use with an implantable medical device for implant within a patient, the method comprising:

concurrently detecting a plurality of cardiogenic impedance signals along different sensing vectors, each vector terminating within a same chamber of the patient'"'"'s heart;

detecting a measure of mechanical dyssynchrony in the same chamber by detecting differences among the cardiogenic impedance signals with respect to a morphological parameter of the cardiogenic impedance signals; and

controlling at least one device function based on the measure of mechanical dyssynchrony

wherein detecting a measure of mechanical dyssynchrony includes;

delivering a pacing pulse to the heart of the patient;

for each of the cardiogenic impedance signals, examining the signal to detect a maximum in a first time derivative of the signal after pulse delivery and then measuring the time delay from the pulse to the maximum in the first time derivative and determining peak velocity delay times for each of the cardiogenic impedance signals; and

comparing the peak velocity delay times derived from the cardiogenic impedance signals to generate the measure of mechanical dyssynchrony.

2. A method for use with an implantable medical device for implant within a patient, the method comprising:

concurrently detecting a plurality of cardiogenic impedance signals along different sensing vectors, each vector terminating within a same chamber of the patient'"'"'s heart;

detecting a measure of mechanical dyssynchrony in the same chamber by detecting differences among the cardiogenic impedance signals with respect to a morphological parameter of the cardiogenic impedance signals; and

controlling at least one device function based on the measure of mechanical dyssynchrony;

wherein detecting a measure of mechanical dyssynchrony includes detecting differences in integrals derived from the cardiogenic impedance signals.

3. The method of claim 2 wherein detecting differences in the cardiogenic impedance signal integrals includes:

delivering a pacing pulse to the heart of the patient;

for each of the cardiogenic impedance signals, integrated a portion of the signal detected after pulse delivery; and

comparing the integrals derived from the cardiogenic impedance signals to generate the measure of mechanical dyssynchrony.

4. The method of claim 2 wherein significant differences in the cardiogenic impedance signal integrals are representative of significant mechanical dyssynchronies within the heart.

5. The method of claim 2 further including identifying hypokinetic segments within the heart of the patient by identifying cardiogenic impedance signals with integrals significantly smaller than the integrals of the other cardiogenic impedance signals.

6. The method of claim 2 further including identifying akinetic segments within the heart of the patient by identifying cardiogenic impedance signals with integrals below a minimum acceptable integral threshold.